Clinical trials: Intestinal Microbiota
Cirrhosis, Liver, Metagonimiasis
Synbiotics Interventions for Managing Cirrhosis and Its Complications
Background Liver cirrhosis is commonly accompanied by intestinal dysbiosis and metabolic defects. Many clinical trials have shown microbiota-targeting strategies represent promising interventions for managing cirrhosis and its…
- Trial name
- NCT05687409
- Testing
- Entecavir 0.5 mg, A 10-g packet of lactulose oral solution and three capsules of probiotics, A 10-g packet of glucose oral solution and three capsules of starch
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Lifestyle (Sedentary Behavior and Physical Activity), Lifestyle Intervention
Healthy Eating and Active Living (HEAL), Exploring Feasibility of a Lifestyle Intervention
Lifestyle interventions combining nutrition, physical activity, and behavioral strategies are increasingly recognized for improving metabolic and psychological health, yet their translation into real-world settings remains…
- Conditions
- Lifestyle (Sedentary Behavior and Physical Activity), Lifestyle Intervention, Lifestyle Modification
- Trial name
- HEAL (NCT07662499)
- Testing
- Multimodal lifestyle intervention (HEAL program)
- Where
- United Arab Emirates
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York University Abu Dhabi
Cannabis Use, Alcohol Use
Alcohol and Cannabis Co-Use and the Gut-Brain Axis
This observational study aims to improve our understanding of how legal market cannabis use impacts acute and long-term alcohol use, the microbiota-gut-brain-axis (MGBA), and neurobehavioral alcohol use phenotypes such as…
- Conditions
- Cannabis Use, Alcohol Use, Inflammation
- Trial name
- FRACTAL (NCT04998006)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gut Microbiome, Mood Disorders
Gut Microbiota in Mood Disorders in Lebanese Population
This study aims to evaluate the pathophysiological aspects of the role of inflammation and gut microbiota in mood disorders, in particular in depression, and their therapeutic implications on a cohort of the Lebanese population.
- Trial name
- NCT05646784
- Testing
- Cerebiome
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- St Joseph University, Beirut, Lebanon
Healthy Subjects
Safety and Efficacy Study of Different DAV132 Dose Regimens in Healthy Volunteers
The purpose of this study is to evaluate whether different DAV132 dose regimens are safe and effective for capturing fecal residues of moxifloxacin in healthy volunteers.
- Trial name
- NCT02917200
- Testing
- Moxifloxacin, DAV132, Negative control
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Da Volterra
Focus on Healthy Infant Growth.
Infant Formula Supplemented With Probiotic Microorganisms and/or Prebiotic.
Evaluation the nutritional suitability of a based milk infant formula supplemented with friendly bacteria (probiotic microorganisms) and or nutritional fibers (prebiotic) to healthy, full term infants compare with an otherwise…
- Trial name
- NCT00836771
- Testing
- Infant Formula
- Where
- Israel
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Materna Laboratories
Blood Pressure, Body Composition, Immune Function
Evaluating the Effects of a Synbiotic Versus Probiotic or Placebo on Gut Microbiota and Cardiometabolic Health: A Randomized Double-Blind Placebo Controlled Trial
Accordingly, the purpose of this study is to evaluate the efficacy of 1) supplementation with Synbiotic (Plexus® Triplex), 2) commercially-available Probiotic, or 3) placebo control over 30 days on the gut microbiome…
- Trial name
- GUTRCT (NCT06544915)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Nutrition Disorders
Interactions Between Diet, Intestinal Microbiota and Metabolomics
It is widely known that the quality of the diet is able to modify the expression of many bacterial genes populating the intestine of the host, as well as the type of bacteria themselves.
- Trial name
- NCT03475368
- Testing
- Vegetarian diet, Low carbs diet, Mediterranean diet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Transgender Persons
Effect of Estrogen Treatment on Drug Metabolism and Transport
This project will evaluate the effect of estrogen treatment on how other medications are processed by the body.
- Trial name
- NCT05469204
- Testing
- Midazolam oral solution, Digoxin Oral Tablet, Acetaminophen Oral Tablet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Washington
Obesity
Hummus for Health: Dietary Quality and Health Outcomes in Toddlers
The goal of this study is to examine the effect of increasing children's intake of fiber and unsaturated fat, through daily servings of hummus and vegetables, on their microbiome profile.
- Trial name
- NCT02696278
- Testing
- Lesson about vegetables, Vegetables, Hummus
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Anemia, Neonatal, Necrotizing Enterocolitis
Alteration of Stool Microbiota in Preterm Infants With Anemia
This study evaluates the relationship between anemia and stool microbiota in premature infants. It also evaluates the relationship between blood transfusion and stool microbiota.
- Conditions
- Anemia, Neonatal, Necrotizing Enterocolitis, Dysbiosis
- Trial name
- NCT03554278
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Acute Myeloid Leukemia, Cachexia
Investigation of the Gut Microbiota in Patients With Acute Myeloid Leukemia
This cohort study aims to investigate the composition and activity of the gut microbiota of patients newly diagnosed for acute myeloid leukemia (AML), in relationship with their food habits and cachectic hallmarks.
- Trial name
- MicroAML (NCT03881826)
- Testing
- collection of clinical data and biological samples
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Gut Microbiome
Neonatal Microbiome Validity Study
This is a validation study to compare proposed field collection methods with a gold standard collection technique for microbiome analysis of stool and breast milk samples.
- Trial name
- NCT02655250
- Testing
- Microbiome
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Healthy
CABALA Diet & Health Study
During digestion of fatty foods, the liver produces a substance called bile which helps with the absorption of fat in the gut (small intestine).
- Trial name
- CABALA (NCT03369548)
- Testing
- Apple, Oats, Lactobacillus reuteri NCIMB 30242
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Reading
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet
Microbiota
Intestinal Microbiota and Thyroid Cancer
Thyroid cancer (TC), the most common malignancy of the endocrine system, is currently the fifth most common malignancy diagnosed in women (1).
- Trial name
- NCT03543891
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Gut Micrbota and Its Relation to Anemia of CKD Patients
Relationship Between Gut Microbiota And Anemia In Patients With Chronic Renal Failure
The human intestinal tract harbours a diverse and complex microbial community which plays a central role in human health. It has been estimated that our gut contains in the range of 1000 bacterial species and 100-fold more genes…
- Trial name
- NCT03220685
- Testing
- Stool analysis
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes, Obesity
Eradication of Gut Microbiota
The aim of the study is to assess the effect of eradication of gut microbiota on 1) glucose metabolism including postprandial plasma responses of the incretin hormones GIP and GLP-1, insulin, C-peptide and glucagon, 2)…
- Conditions
- Diabetes, Obesity, Osteoporosis, Inflammation
- Trial name
- ERA (NCT01633762)
- Testing
- meropenem, gentamicin, vancomycin (together)
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity, Abdominal, Diabete Type 2
Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles
The proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite…
- Trial name
- METAc (NCT05917132)
- Testing
- Nutritionnal intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laval University
Drug Resistant Epilepsy
Role of the Gut Microbiota in Pediatric Epilepsy
Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children.
- Trial name
- EPBiome (NCT04705298)
- Testing
- Prebiotic
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- British Columbia Children's Hospital
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