Clinical trials: Intestinal Microbiota
Colorectal Cancer
The Effects of Replacing Red and Processed Meat With Quorn on Biomarkers of Gut Health
This study will evaluate the effects of substituting red and processed meat in the diet with Quorn; a meat replacement product, on biomarkers of gut health.
- Trial name
- MYCOMEAT (NCT03944421)
- Testing
- Red and Processed Meat, Quorn
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Insulin Resistance
Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance
The primary aims of the current study: using L-carnitine supplementation modulate the level of plasma trimethylamine N-oxide to assess its effect on circulating cytokines related to diabetes and metabolic syndrome; using…
- Trial name
- MR (NCT05251207)
- Testing
- L-carnitine, L-leucine, Change of the circadian cycle
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Diet Modification
Effects of Consuming Red Meat on the Gut Microbiota in Young Adults
The purpose of this study is to assess the impact of consuming unprocessed and processed red meat on gut microbiota in young healthy adults in a cross-over, randomized controlled feeding trial.
- Trial name
- S51 (NCT03885544)
- Testing
- Controlled Lacto-ovo vegetarian diet, Controlled Unprocessed red meat diet, Controlled processed red meat diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Purdue University
Healthy
Effect of Prebiotic Intake on Gut Microbiota in Healthy Adults
In recent years, the importance of the gut microbiota to human health has been demonstrated. In adulthood, the microbial profile is relatively stable, yet can be transiently altered by factors such as diet or antibiotic…
- Trial name
- NCT03042494
- Testing
- Control, Prebiotic
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Rheumatoid Arthritis, Fibromyalgia
Gut Microbiota: a Player in Chronic Pain in Patients With Rheumatoid Arthritis?
Although rheumatoid arthritis (RA) treatments are very effective in reducing inflammation, chronic pain persists in 20 to 30% of patients.
- Trial name
- MiSenDol (NCT05822856)
- Testing
- Blood sampling and others interventions
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight
Study of Grape Consumption in Adaptation to Seasonal Photoperiod
The goal of this randomized clinical trial is to learn whether consuming grapes during their natural season can help the body adapt to the shorter daylight hours of winter.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight, Obesity & Overweight
- Trial name
- PhotoGrape (NCT07886788)
- Testing
- Freeze-Dried Grape Powder, Plain Low-Fat Yogurt, Mediterranean-Style Dietary Guidance
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Gastrointestinal Microbiome
Modulation of the Gut Microbiota of Professional Athletes With Sauerkraut Supplementation
Literature on the topic of athlete gut microbiota is scarce, and even more on the topic of its modulation. To address these issues a prospective cohort study was conceived.
- Trial name
- KOMS (NCT06087146)
- Testing
- Sauerkraut (Brassica oleracea v. capitata)
- Where
- Croatia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Gut Microbiome Center (Centar za crijevni mikrobiom)
Obesity, Diabetes
Effects of Non-nutritive Sweeteners on the Composition of the Gut Microbiome
This pilot study is being conducted to evaluate whether consumption of diet soda sweetened with sucralose and acesulfame-potassium leads to changes in the gut microbiota.
- Trial name
- NCT02877186
- Testing
- commercially-available diet soda, carbonated water (control)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- George Washington University
Autoimmune Diseases
Gut Microbiota In Children With Autoimmune Liver Disease and Its Effect on Treatment Response
Gut microbiota and liver disease are very closely linked. Microbiota influences the various liver diseases by Dysbiosis ratio .There is loss of tolerance targeting liver antigens which is thought to initiate disease in…
- Trial name
- NCT06183190
- Testing
- No intervention
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Intolerance to "Conventional" Bread
Tolerance to an Artisanal Bread in a Population Intolerant of the Conventional Bread and Study of Associated Markers
The objective of this study is to evaluate the effect of consuming an "artisanal" bread for 15 days on gastrointestinal symptoms in individuals intolerant to "conventional" bread.
- Trial name
- TOLERBREAD (NCT07568223)
- Testing
- Artisanal Bread
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms
The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight
The study is a single-center, randomized, double-blind, placebo-controlled study in middle-aged to elderly adults with excessive body weight. The study includes an 8-week intervention period followed by a 2-week follow-up period.
- Trial name
- myBIOM (NCT07453823)
- Testing
- Synbiotic
- Where
- Ireland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chr Hansen - part of Novonesis
Gut Microbiota, Hyperglycemia
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
Mexico is going through a major environmental and nutritional crisis, which is related to unsustainable dietary behaviors. Sustainable diets could solve both problems together.
- Conditions
- Gut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLC
- Trial name
- NCT05457439
- Testing
- Sustainable diet promotion through behavioral change intervention
- Where
- Mexico
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Beneficial Bacteria in Gut
Color Synbiotics Study
This study is initiated to investigate the effect of infant formula with added specific synbiotics mixture on proportion of beneficial bacteria.
- Trial name
- NCT01813175
- Testing
- Regular non-hydrolysed cow's milk I, Regular non-hydrolysed cow's milk II, Regular non-hydrolysed cow's milk - control
- Where
- 3 sites in Thailand
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Obesity (Disorder)
Three M Study (Malabsorption, Microbiota, Mini-Gastric Bypass)
Bariatric surgery represents the best therapeutic option to induce sustainable weight loss and to solve serious comorbidities improving the life-expectancy and the quality of life.
- Trial name
- NCT03412149
- Testing
- Mini Gastric Bypass, Roux en Y Gastric Bypass
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Pancreas-kidney Transplantation, Kidney Transplantation
Bile Acids and Incretins in Pancreas Kidney Transplant Patients
Pancreas Kidney Transplantation (PKT) is the prominent treatment for type 1 diabetic patients with chronic kidney disease and improves patients' outcome.
- Trial name
- ITABI (NCT02234349)
- Testing
- pancreas kidney transplantation, kidney transplantation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Menopause
Milk on Gut Microbiome and Bone Remodeling CTX in Postmenopausal Women
Milk consumption drives beneficial effect on Bone Mass Density and on Gut Microbiome. Altered Gut Microbiome is associated with postmenopausal status, reduced Bone Mass Density, abnormal serum levels of Bone Turnover Markers…
- Trial name
- Milk-CTX-GM (NCT06050018)
- Testing
- YesMilkdiet, NoMilkdiet
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Crohn Disease
Mother-to-Infant Transfer of Bacteriome, Fungome, Virome, and Metabolome in Health and Crohn's Disease
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are caused by the loss of mucosal tolerance towards the commensal microbiota resulting in inflammatory responses.
- Trial name
- NCT05112497
- Testing
- No intervention procedure
- Where
- Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong