Clinical trials: Intestinal Microbiota
Microtia
The Effect of Prebiotics on Endurance Performance
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
- Trial name
- NCT04946578
- Testing
- Prebiotic
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Ulcerative Colitis
Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis
The researchers will investigate gut microbiome in Korean patients with ulcerative colitis and normal control subjects using metagenomic analysis to elucidate the significant difference between two groups This study will help to…
- Trial name
- NCT01010815
- Testing
- Colonoscopy biopsy, stool collection
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Intermittent Fasting, Gut Microbiome
The Rufaida Project: Researching the Impact of Ramadan Fasting on the Gut and Vaginal Microbiome
The body's systems are deeply connected, but they are often studied separately. A recent large-scale citizen-science project on women's health, called Isala, discovered a group of gut-related bacteria present in the vaginal…
- Conditions
- Intermittent Fasting, Gut Microbiome, Vaginal Microbiome
- Trial name
- Rufaida (NCT07001358)
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Overweight, Obesity
Effect of Prebiotic Intake on Adiposity, Satiety and Gut Microbiota in Overweight and Obese Children
Currently, over one third of Canadian children and youth aged five to seventeen are overweight or obese. Childhood obesity leads to increased risks of co-morbidities such as type 2 diabetes, fatty liver disease, cardiovascular…
- Trial name
- NCT02125955
- Testing
- Prebiotic fiber
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy
Lacticaseibacillus Rhamnosus GG Pili Study
The aim of this study was to investigate the host-microbe interaction effects of various Lacticaseibacillus rhamnosus GG strains, with different binding capacities to the mucus in the small intestine, in healthy individuals
- Trial name
- NCT05461443
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Asphyxia Neonatorum, Morbidity;Newborn
Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment
The VISNAT trial is a PILOT STUDY due to absence of previous evidences in literature on using probiotic in newborns with perinatal asphyxia.
- Trial name
- VISNAT (NCT04145713)
- Testing
- Probiotic mixture
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Cognitive Decline
The Impact of Exercise on Hippocampus-dependent Cognition and the Gut Microbiota
The NeuroFit study will be investigating the impact of exercise on global cognition, hippocampus-dependent memory function and the gut microbiota in a middle-aged population.
- Trial name
- NeuroFit (NCT05397990)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- King's College London
Irritable Bowel Syndrome With Diarrhea
Intestinal Permeability and Intestinal Microbiota in Irritable Bowel Syndrome
Patients with diarrhea-predominant irritable bowel syndrome (IBS) and functional dyspepsia (FD) were examined and received treatment in the study.
- Trial name
- NCT05379036
- Testing
- prescribing anapproved drug, examination
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Fasting, Dietary Fibre
Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits
This study builds on the knowledge that fasting provides metabolic health benefits and that prebiotic interventions can enhance the gut microbiome's metabolic output to likewise improve host health.
- Conditions
- Fasting, Dietary Fibre, Gut Microbiome, Metabolism Changes
- Trial name
- CoFFIe (NCT07691736)
- Testing
- Fibre Arm, Control Arm
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Boswellia Serrata, Irritable Bowel Syndrome
Positive Outcomes of the Supplementation With Lecithin-based Delivery Form of Curcuma Longa and of Boswellia Serrata in IBS
Small bowel dysbiosis (SBD), is a frequent finding in subjects with irritable bowel syndrome (IBS). The formula-tion in sunflower lecithin (Phytosome) of Curcuma longa and Boswellia serrata demonstrated beneficial effects on…
- Trial name
- NCT06407609
- Testing
- Curcuma and boswellia extracts plus low fodmap diet, Low Foodmap diet
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Probiotics, Prebiotics
Super 13 Pro & Prebiotics on the Human Intestinal Microflora
This study aim to investigate the roles of the test article in improving gastrointestinal functions and gut microbiota of humans.
- Trial name
- NCT04043000
- Testing
- Super 13 Pro & Prebiotics
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cheng-Hsin General Hospital
Anorexia Nervosa
Active Lifestyle Intervention in Anorexia Nervosa: a Comprehensive Study
The goal of this study is to perform a comprehensive analysis of varied health markers and analyze the impact of lifestyle interventions on the prognosis of anorexia nervosa (AN) patients.
- Trial name
- DiANa (NCT06866301)
- Testing
- Progressive Resistance Exercise
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora
Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
This is an observational case-control study, aiming to systematically analyze the gut microbiome characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora, Multiple Myeloma, M-Protein
- Trial name
- NCT06690593
- Where
- China
- Volunteers
- 2,990 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Microbial Colonization
Investigating the Impact of Humiome B2 (Colon Delivered Riboflavin) and Riboflavin-overproducer Probiotic Strain Limosilactobacillus Reuteri AMBV339 on Intestinal and Vaginal Microbiome and Health of Healthy Adult Women (The VIAB2L Project)
The goal of this clinical trial is to learn if the probiotic strain Limosilactobacillus reuteri AMBV339 or colon-delivered riboflavin or their combination can change the gut and vaginal microbiome and metabolomics.
- Trial name
- VIAB2L (NCT06425081)
- Testing
- Limosilactobacillus reuteri AMBV339, Humiome B2, Limosilactobacillus reuteri AMBV339 + Humiome B2
- Where
- Belgium
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Peutz-Jeghers Syndrome
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11…
- Trial name
- NCT03806075
- Testing
- Second generation sequencing, 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yiqi Du
Gut Microbiome
Effects of a Novel Food Product Containing Microbiota Accessible Carbohydrates on the Human Microbiome
This is a randomized, 2-period crossover study aimed at assessing the effect of taking a food supplement containing a blend of microbial accessible carbohydrates on the diversity of the gut microbiome.
- Trial name
- NCT03058575
- Testing
- Dietary MACs, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Access Business Group
COVID-19
The Effect of Helminth Infection Plus COVID-19 Infection on the Immune Response and Intestinal Microorganisms
This is a pilot, cross-sectional, sample collection study to characterize the immune response and intestinal microorganisms in people with and without COVID-19 antibodies and helminth infection.
- Trial name
- NCT04813328
- Where
- India
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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