Clinical trials: Intestinal Microbiota
Eating Disorders Symptoms
Effects of Fecal Microbiota Transplantation
The intestinal microbiota plays an essential role in digestion and, through the gut-brain axis, in the regulation of weight gain and eating behavior.
- Trial name
- Transmic-TCA (NCT07196189)
- Testing
- Patients, healthy volunteer
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Personalized Nutrition
ZOE METHOD Study: Comparing Personalized vs. Generalized Nutrition Guidelines
The ZOE Method Study will test the efficacy of personalized nutritional advice, delivered on an individual level through a digital device app; integrating dietary, lifestyle, physiological and metagenomic data, in improving…
- Trial name
- NCT05273268
- Testing
- Personalized nutrition, Generalized nutrition
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Menopause
Milk on Gut Microbiome and Bone Remodeling CTX in Postmenopausal Women
Milk consumption drives beneficial effect on Bone Mass Density and on Gut Microbiome. Altered Gut Microbiome is associated with postmenopausal status, reduced Bone Mass Density, abnormal serum levels of Bone Turnover Markers…
- Trial name
- Milk-CTX-GM (NCT06050018)
- Testing
- YesMilkdiet, NoMilkdiet
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Hypercholesterolemia
Plant Stanols and Gene Expression Profile
Plant sterols and stanols are dietary components that are naturally present in plants. Their biological function in plants is comparable with these of cholesterol in animals.
- Trial name
- NCT01574417
- Testing
- control margarine, plant stanol-enriched margarine
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gastrointestinal Disorder, Functional
PHAGE Study: Bacteriophages as Novel Prebiotics
The PHAGE study is designed to determine if a commercial prebiotic product can change the composition of bacteria in the gut for improved intestinal health.
- Trial name
- NCT03269617
- Testing
- Bacteriophage mixture
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Infant Development
Early Iron Exposure on the Gut Microbiota in Young Infants
This study will look at the amount of iron in infant formula and how that affects a child's gut development. The children of mothers who plan to formula feed their children will be randomized to receive either high iron or low…
- Trial name
- IF (NCT03828708)
- Testing
- Iron in infant formula
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Respiratory Diseases
Intestinal Microbiota in COPD and Asthma
The composition of the intestinal microbiota, the level of lipopolysaccharides, TMAO in the blood, and other parameters of patients with COPD (n=50), asthma (n=50) and the control (n=40) will be assessed as factors associated…
- Trial name
- MicrObAs (NCT04802317)
- Testing
- Identification of the composition of the intestinal microbiota
- Where
- Russia
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Irritable Bowel Syndrome
Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome
To determine the efficacy of a low FODMAP diet in IBS patients and whether gut microbiota community is associated with its efficacy.
- Trial name
- NCT02565550
- Testing
- low FODMAPs
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shandong University
Obesity
Microbiota in Dietary Approach to Obesity
Main aim: Study the anthropometric, metabolic, cardiovascular and neurocognitive and gut microbiota changes of different approaches for the weight reduction that increase the ketone bodies in a different proportion in relation to…
- Trial name
- NCT04453150
- Testing
- Standard hypocaloric die, Intermittent fasting 16/8 (early fasting), Intermittent fasting 16/8 (late fasting)
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Changes in Gut Microbiota, Gut Metabolites, Respiratory Symptoms, and Well-being Index
A Probiotic for Health Outcomes in Short-Term Overseas Travel
With the improvement of living standards, travel has become a common form of leisure. However, travelers often face changes in living environments, dietary habits, and sleep schedules, all of which can impact the gut microbiota…
- Trial name
- NCT07705659
- Testing
- Bifidobacterium longum, Maltodextrin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DiproBio (Shanghai) Co., Ltd.
Healthy Subjects
On the Impact of Common Sweetening Agents on Glucose Regulation, Cognitive Functioning and Gut Microbiota
The study intention is to investigate, in healthy humans, effects of 3 commonly used sweeteners on cardiometabolic risk markers, cognitive functions, and influences on gut microbiota composition.
- Trial name
- NCT02580110
- Testing
- Sucrose, Stevia glycosides, saccharin
- Where
- Sweden
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Lund University
Metabolism
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
The purpose of this research is to determine the production of trimethylamine-N-oxide (TMAO) from different forms of choline and whether this response is modified by the gut microbiota composition.
- Trial name
- NCT04255368
- Testing
- Water-soluble choline, Fat-soluble choline, No choline control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Utah State University
Type1diabetes
Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of…
- Trial name
- MAIT-DT1 (NCT05054361)
- Testing
- MAIT cells analysis, MAIT cytokines production analysis, Lactulose/Mannitol Test
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Vaginal Microbiome, Gut Microbiome
The Effect Cranberry-Based Products on the Female Microbiome
The overall objective of this clinical trial is to compare the effects of a cranberry-based product to a placebo-control product on vaginal and GI microbiome outcomes and associated participant reported outcomes in generally…
- Conditions
- Vaginal Microbiome, Gut Microbiome, Gut Health
- Trial name
- NCT07109713
- Testing
- Active
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ocean Spray Cranberries, Inc.
Postprandial Hyperglycemia, Metabolic Disorder, Glucose
Westlake N-of-1 Trials for Macronutrient Intake 2 ( WE-MACNUTR 2)
Diet and nutrition are key to maintain human health. Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR) trial investigates individualized postprandial glycemic responses to different proportions of dietary fat and…
- Trial name
- NCT05161182
- Testing
- High fat, low carbohydrate diet, Low fat, high carbohydrate diet
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Westlake University
Healthy
The Impact of Diet on the Gut-Microbiota-Brain Axis
This study aims to investigate the effects of an 8-week dietary intervention on cognitive function, stress, and the gut microbiota in healthy adults with low fibre intake.
- Trial name
- NMB (NCT05931562)
- Testing
- Fermented Foods, High Fibre, Combined Diet
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College Cork
Obesity, Bariatric Surgery
Potential Associations Between Alterations in Gut Microbiome and Obesity-related Traits After the Bariatric Surgery
This study aimed to examine the effects of obesity and bariatric surgery on gut microbiota in a Turkish population, and to contribute to the literature by bringing multi-dimensional parameters including dietary intake, metabolic…
- Trial name
- NCT05085769
- Testing
- Bariatric surgery
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms
The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight
The study is a single-center, randomized, double-blind, placebo-controlled study in middle-aged to elderly adults with excessive body weight. The study includes an 8-week intervention period followed by a 2-week follow-up period.
- Trial name
- myBIOM (NCT07453823)
- Testing
- Synbiotic
- Where
- Ireland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chr Hansen - part of Novonesis
Microbial Colonization
Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system.
- Trial name
- NCT03273296
- Testing
- Amoxicillin, Azithromycin, Vancomycin
- Where
- Finland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Healthy Adults
Enteral Nutrition and Immune Proteins Study
Eligible healthy adults who consent to take part in the study will be randomised to receive either a specialised milkshake for all of their normal daily diet (exculsive enteral nutrition, EEN) or the same specialised milkshake…
- Trial name
- ENIP (NCT06828094)
- Testing
- enteral nutrition
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
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