Clinical trials: Intestinal Microbiota
Gut Microbiota
Impact of Probiotics Supplement on the Gut Microbiota in Caesarean-born Infants
The purpose of this study is to evaluate the effect of probiotics on the gut microbiota of infants born by cesarean section.
- Trial name
- NCT05086458
- Testing
- probiotics
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Microbiota
Gut Microbiota and Nonpuerperal Mastitis
Nonpuerperal mastitis (NPM), mainly including Plasma cell mastitis (PCM) and Granulomatous mastitis (GM), which clinical presentation is an accessible and painful breast mass accompanied by skin redness and swelling, nipple…
- Trial name
- NCT05051215
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Systemic Lupus Erythematosus (SLE)
Mediterranean Diet and Gut Microbiota in Children With Systemic Lupus Erythematosus
The goal of this clinical trial is to learn if a Mediterranean diet can improve gut microbiota, disease activity, and nutrition in children with systemic lupus erythematosus (SLE).
- Trial name
- NCT07555626
- Testing
- Mediterranean Diet-Based Individual Nutrition Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Healthy
ButyraGen™, Short Chain Fatty Acids and Gut Microbiome
This study is being conducted to demonstrate short chain fatty acid (SCFA), specifically butyrate, generation in stool, blood and urine in response to oral intake of ButyraGen™.
- Trial name
- BG (NCT05601635)
- Testing
- ButyraGen™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Dietary Habits, Bowel Dysfunction
Fiber and Water Improve Bowel Habit in Humans
Twenty healthy volunteers had their baseline parameters (symptoms, bowel habit, quality of life, fecal characteristics and microbiota) measured during a week of monitoring followed by randomization to a 14 days course of…
- Trial name
- NCT02838849
- Testing
- Fiber, Fiber and Water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade de Passo Fundo
Gut Inflammation, Overweight and Obese Volunteers
Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity.
Inflammatory bowel disease (IBD) affects over 6.8 million people worldwide, with current treatments often causing side effects and poor patient compliance.
- Trial name
- NCT07253155
- Testing
- Probiotic Arm
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Microscopic Colitis
Faecal Microbiota Transplantation in Patients With Microscopic Colitis
Microscopic colitis (MC) is a disease with chronic inflammation of the colon that is mostly diagnosed in middle-aged or elderly women. Patients suffer from chronic watery diarrhoea, abdominal pain and weight loss.
- Trial name
- NCT03275467
- Testing
- Faecal microbiota transfer (FMT)
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Hypertension
Gut Butyrate and Blood Pressure in African Americans
African Americans have the greatest burden of hypertension. Recently, the short-chain fatty acid, butyrate, has been reported to have some effect on blood pressure.
- Trial name
- NCT04415333
- Testing
- Sodium Butyrate 5 mmol, Sodium Butyrate 80 mmol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension, Gut Microbiota
Metagenomic Analysis of Gut Microbiota in Untreated and Uncontrolled Hypertensive Patients
This observational study aims to explore the relationship between gut microbiota composition and blood pressure regulation in patients with hypertension.
- Trial name
- HyGut (NCT06284928)
- Testing
- Fecal Sample Collection
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Xinjiang Medical University
Healthy
The Influence of IgY Max on Inflammatory Markers and the Gut Microbiome
The purpose of this study is to determine the optimal dose of IgY as assessed by changes in the inflammatory marker, C-reactive protein and investigate the effect of IgY on the gut microbiome as assessed by 16s RNA sequencing of…
- Trial name
- NCT02972463
- Testing
- Immunoglobulin Y
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Igy Nutrition, LLC
Carotenoid Status, Gut Microbiome
Probiotics for Enhanced Tissue Carotenoid Status in Premenopausal Women
Carotenoids are yellow-orange fat soluble plant pigments primarily obtained from the diet that serve as an accurate biomarker for fruit and vegetable intake.
- Conditions
- Carotenoid Status, Gut Microbiome, Skin Health
- Trial name
- ProCar (NCT04511052)
- Testing
- Probiotic, Carotenoid supplement
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- McGill University
Aging
Age-associated Arterial Dysfunction, Western Diet, and Aerobic Exercise: Role of the Gut Microbiome
The risk of developing cardiovascular diseases increases with aging largely due to age-related declines in the function of arteries (arterial dysfunction), which are influenced by common lifestyle factors such as consumption of a…
- Trial name
- NCT03334201
- Testing
- Western Diet, Non-Western Diet
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Spondyloarthritis, Ruminococcus Gnavus
The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in…
- Trial name
- RUMINOSPA (NCT04853212)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Complex Regional Pain Syndromes
Role of the Gut Microbiome in Complex Regional Pain Syndrome
The objective of this prospective, observational study is to determine the association between the composition of the gut microbiota and the severity and persistence of Complex Regional Pain Syndrome symptoms (Study A).
- Trial name
- NCT03612193
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Gut Microbiota
Effect of an Infant Formula With Synbiotics in Infants Born Via Caesarean Section
A multi-centre, randomized, parallel-group, double-blind, controlled, exploratory clinical trial is conducted to assess the positive effect of feeding a formula containing synbiotics (pre- and probiotics) on the composition of…
- Trial name
- GOLF-CS (NCT04991792)
- Testing
- Intervention Group 1: Infant Formula with synbiotics, Intervention Group 2: Infant Formula with prebiotics, Control Group 1 and 2: Infant Formula without synbiotics
- Where
- Bulgaria
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Cirrhosis, Liver, Metagonimiasis
Synbiotics Interventions for Managing Cirrhosis and Its Complications
Background Liver cirrhosis is commonly accompanied by intestinal dysbiosis and metabolic defects. Many clinical trials have shown microbiota-targeting strategies represent promising interventions for managing cirrhosis and its…
- Trial name
- NCT05687409
- Testing
- Entecavir 0.5 mg, A 10-g packet of lactulose oral solution and three capsules of probiotics, A 10-g packet of glucose oral solution and three capsules of starch
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Healthy
Effect of Lactobacillus Casei Shirota on the Small Intestinal Microbiota (ROBIN)
Currently, obtaining samples directly from the small bowel is difficult due to the highly invasive intubation methods used. Research on the effect of dietary probiotics on the gut microbiota is therefore largely dependent on…
- Trial name
- ROBIN (NCT03114839)
- Testing
- Lactobacillus casei strain Shirota (LcS)
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yakult Honsha European Research Center, ESV
Colic, Infantile, Probiotic
NEOBIFI: Clinical Trial for the Prevention and/or Reduction of the Incidence of Colics in Infants
Infant colics represent a clinical condition in childhood, characterized by an uncontrollable crying that occurs without any apparent organic cause.1 They can be associated with face redness, closed fists, thighs flexion…
- Conditions
- Colic, Infantile, Probiotic, Gut Microbiome, Bifidobacterium Breve
- Trial name
- NEOBIFI (NCT03219931)
- Testing
- Bifidobacterium breve BR03 and Bifidobacterium breve B632
- Where
- Italy
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Microbiota, Nutrition, Healthy
Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Unhealthy diets are closely linked to non-communicable diseases and constitute higher risk of morbidity and mortality than unsafe sex, alcohol, tobacco and drugs use combined.
- Trial name
- SUSUGUT (NCT05231317)
- Testing
- Plant-based diet, Western diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Healthy
The Roles of Gut Microbiome in UTI Susceptible Women
Clinical trials on cranberry juice and UTI prevention yielded both positive and negative results for unknown reason. Gut microbiome in women affect the absorption and metabolism of cranberry bioactives.
- Trial name
- NCT05065008
- Testing
- Cranberry juice, Apple juice
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Florida
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