Clinical trials: Intestinal Transit
Constipation
Assessment of Whole Gut Transit Time Using the SmartPill Capsule
Our null hypothesis states that the two techniques (Sitzmarks radioopaque markers and SmartPill) are equivalent and is demonstrated if the study population shows a correlation of 0.7 or higher.
- Trial name
- WholeGut (NCT00603707)
- Where
- 8 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- The SmartPill Corporation
Constipation-predominant Irritable Bowel Syndrome
Cheno Effect on Transit in Health and IBS-C
The study hypothesis is that the naturally occurring bile acid, chenodeoxycholic acid, induces acceleration of colonic transit in health and in patients with constipation-predominant Irritable Bowel Syndrome (IBS-C).
- Trial name
- Chenotransit (NCT00912301)
- Testing
- Sodium chenodeoxycholate (NaCDC)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Esophageal Cancer, Nutrition Disorders
Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery
The incidence of oesophagogastric cancer has increased by 400% since the 1970s in Ireland and the United Kingdom. In addition, refinement of perioperative management and the now widespread use of multimodal protocols for patients…
- Conditions
- Esophageal Cancer, Nutrition Disorders, Appetite Disorders, Dumping Syndrome
- Trial name
- EndoGut (NCT03734627)
- Testing
- Octreotide Acetate, Saline Solution, Paracetamol
- Where
- 2 sites in Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Ulcerative Colitis
TP0502-Pharmaco-Scintigraphic-Study and Amendment
This is a Phase I, open-label, single-site trial to evaluate the drug release, using scintigraphic images and mesalazine plasma levels (PK) in healthy subjects and patients with mildly active UC.
- Trial name
- NCT02306785
- Testing
- TP05 Coating D, TP05 Coating E, TP05 Coating H
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Tillotts Pharma AG
IBS - Irritable Bowel Syndrome
Gluten Free Diet in IBS Patients Stratified According to Their Antigliadin Status
Gluten-free diet has been shown to improve gut symptoms in patients with celiac disease and also in adult patients with diagnosis of Irritable Bowel Syndrome (Rome III criteria).
- Trial name
- GFD_IBS (NCT03492333)
- Testing
- Gluten free diet
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- McMaster University
Constipation
Effects of Cultura Yoghurt in Relation to Transit Time and Digestive Discomfort in Healthy Women and Men
The aim of this study is to determine the effect of cultura yoghurt on transit time and digestive discomfort during 2 weeks of treatment in comparison to placebo in healthy women and men.
- Trial name
- NCT01102036
- Testing
- Cultura L casei F19, acidophilus La5 , B lactis Bb 12, Yoghurt without probiotics
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Good Food Practice, Sweden
Ulcerative Colitis
TP0501 - Pharmaco-Scintigraphic-Study
This is a Phase I, open-label, single-site trial to evaluate the drug release, using Scintigraphic images and mesalazine plasma levels (PK) in healthy subjects.
- Trial name
- NCT02306772
- Testing
- TP05 Coating A, TP05 Coating B
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tillotts Pharma AG
Healthy
Effect of ATI-7505 on Gastrointestinal Transit in Healthy Volunteers
This is a pharmacodynamic study in healthy volunteers to determine the effects of a new 5-HT4 agonist on gastric, small bowel and colonic transit.
- Trial name
- NCT01094821
- Testing
- ATI-7505
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spinal Cord Injury
Examining the Distal Gut Microbiome After Spinal Cord Injury
The purpose of this research study is to learn more about the causes of gastrointestinal dysfunction after spinal cord injury. It has been thought that the microbiome (the community of bacteria in the body) may be one such cause.
- Trial name
- NCT03319225
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Miami
Colo-rectal Cancer
Motility of the Check-cap's MD1 Colon Capsule in Subjects Following Colon Rectal Cancer Screening by Colonoscopy
To monitor the Whole Gut Transit Time and repeatability of the motility of MD1 capsules in the colon of subjects with known polyps and in healthy subjects. Multi-Center, Open, Home Monitoring, Prospective Study.
- Trial name
- NCT03785665
- Testing
- MDI
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Irritable Bowel Syndrome
Small and Large Bowel Transit Tests Using MRI (Study 1)
Irritable bowel syndrome, (IBS) is a common functional disorder of the gut that can be quite disabling to patients. The most common symptoms of IBS are abdominal pain or discomfort along with erratic changes in bowel habit of…
- Trial name
- NCT01534507
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Slow Transit
The Effect of Sham Feeding on Small Bowel Transit Time in Patients Undergoing Capsule Endoscopy
Capsule endoscopy is a non-invasive way to examine the small bowel, but its yield is limited by the battery life. In 20% of cases, the recording stops before the entire length of small bowel is examined.
- Trial name
- NCT02353208
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intestinal Obstruction
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and…
- Trial name
- LOP-MNTX-2009 (NCT01596777)
- Testing
- Loperamide, Methylnaltrexone 12 mg sc., Methylnaltrexone IR capsule
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Obesity
Gut Hormone Response, Appetite and Intestinal Transit Time in Good and Poor Weight Responders After Gastric Bypass
The aim of the study is to describe differences in meal-stimulated gut hormone response, appetite and intestinal transit time between good and poor responders 1-2 years after Gastric Bypass surgery for obesity.
- Trial name
- RnonR (NCT00908973)
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Functional Constipation
Multistrain Probiotic for Functional Constipation
Subjects will be screened and will enter a placebo-only 2-week run-in period during which constipation symptoms will be evaluated and any disallowed products (e.g. probiotics) must be discontinued.
- Trial name
- NCT01618617
- Testing
- High dose Multistrain probiotic, 100 billion cfu/day, Low dose Multistrain probiotic, 15 billion cfu/day
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Renew Life Formulas Inc
Intestinal Diseases
Squatting on the Toilet and Capsule Endoscopy
This study evaluates the effect of squatting on the toilet on gastric transit time and complete examination rate of capsule endoscopy.In the observation group, the patients could go to squatting on the toilet at any time as they…
- Trial name
- SC (NCT04340089)
- Testing
- squatting on the toilet
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Irritable Bowel Syndrome
A Phase I, Randomized, Placebo-controlled, Double Blind, Repeat Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Gastrointestinal Transit Time and Pharmacodynamic Biomarkers of GSK3179106 in Normal Subjects
The current study is designed to assess the safety, tolerability, pharmacokinetics (PK), gastrointestinal (GI) transit time and pharmacodynamic (PD) biomarkers of repeat oral doses of GSK3179106 administered for 14 days in normal…
- Trial name
- NCT02798991
- Testing
- GSK3179106
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Slow Transit Constipation
Using 16S rRNA Gene Sequencing Analysis Intestinal Microbiota in Constipation Patients
Constipation is a frequent, chronic gastroenterological problem that has many varied symptoms and thus has several clinical definitions.
- Trial name
- NCT02984969
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Diet, Healthy, Metabolic Disease
Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism
The aim of this study is to investigate how a short versus a long transit time impacts the gut microbiome's response to a high-fiber and a low-fiber diet, respectively.
- Trial name
- PRIMA-KOST (NCT06022302)
- Testing
- Diet + laxative, Diet only
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Volunteers
Feasibility Study of an Innovative Medical Device for Sampling the Contents of the Small Intestine.
For the first time in the world, the objective of this study is to evaluate on healthy volunteers, an innovative medical device for the capture of intestinal liquid.This medical device is not yet CE marked.
- Trial name
- DIGEST (NCT05477069)
- Testing
- Innovative medical device for sampling small intestine content
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble