Clinical trials: Intestinal Transplantation
Aging, Frailty
Effect of Gut Microbiome Intervention on Aging Via Oral FMT
A severe public health issue facing global population is aging. Increasing preclinical and clinical data indicate the contribution of gut microbiome on aging and aging-related diseases such as cardiovascular disease, Alzheimer…
- Trial name
- STEP-aging (NCT05598112)
- Testing
- FMT capsules
- Where
- 6 sites in China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ulcerative Colitis
Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis (UC)
This study included two topics: one was to test the efficacy and safety of fecal microbiota transplants plus partial enteral nutrition (PEN) in refractory pediatric UC where conventional therapy has failed, and the other was to…
- Trial name
- FMT (NCT05679622)
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biao Zou
Liver Failure
Fecal Microbiota Transplantation for Liver Failure
To investigate the safety, adverse reactions and therapeutic effects of fecal microbiota transplantation on patients with liver failure;to investigate the effect of fecal microbiota transplantation on the intestinal microecology…
- Trial name
- NCT05170971
- Testing
- fecal microbiota transplantation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Intestinal GVHD, Neutropenic Enterocolitis
Non-invasive Contrast Enhanced Ultrasound Sonography in Intestinal Acute Graft-vs-Host Disease
Intestinal acute graft-vs-host disease (GVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation. Non-invasive diagnostic procedures are still lacking and diagnosis is difficult.
- Trial name
- NCT01699516
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Alcohol Use Disorder (AUD), Alcohol Abstinence
Investigation of the Gut-Brain Axis in Alcohol Use Disorder
A non-profit study involving patients with moderate-to-severe Alcohol Use Disorder (AUD), designed to investigate whether correcting intestinal dysbiosis through Fecal Microbiota Transplantation (FMT) from healthy abstinent…
- Trial name
- FMT-ACT (NCT07902635)
- Testing
- Fecal Microbiota Transplantation (FMT) Procedure and Cognitive Behavioral Therapy (CBT) Procedure
- Where
- Italy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Graft Vs Host Disease
Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT
This research project delves into the critical role of gut immunity in the occurrence and progression of acute graft-versus-host disease (aGVHD) post allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT06143501
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Ulcerative Colitis
Fecal Microbiota Transplantation as a Treatment for Ulcerative Colitis
Ulcerative colitis (UC) is characterized by a disrupted homeostasis of the commensal bacterial population (dysbiosis). A promising therapy for restoration of the altered balance of the enteric microbiota is fecal microbial…
- Trial name
- NCT04434872
- Testing
- Colonoscopy, Gastroscopy, Fecal Microbiota
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Microscopic Colitis
Faecal Microbiota Transplantation in Patients With Microscopic Colitis
Microscopic colitis (MC) is a disease with chronic inflammation of the colon that is mostly diagnosed in middle-aged or elderly women. Patients suffer from chronic watery diarrhoea, abdominal pain and weight loss.
- Trial name
- NCT03275467
- Testing
- Faecal microbiota transfer (FMT)
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
IBS - Irritable Bowel Syndrome, Microbial Substitution
The Optimal Route of Fecal Microbiota Transplantation for Irritable Bowel Syndrome
The object of this study is to find out is there an optimal route for the fecal microbiata transplant (FMT) in patients that suffer from irritable bowel syndrome.
- Trial name
- NCT05874830
- Testing
- Fecal microbiota transplant or plasebo through endoscopy
- Where
- 3 sites in Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD)
Fecal Microbiota Transplantation in Pediatric Patients
A disturbance in the diversity of gut bacterial composition could be linked to several immune mediated diseases including inflammatory bowel diseases (IBD).
- Conditions
- Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FMT (NCT02108821)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Healthy, Chronic Kidney Diseases
Innovative Approach to Fecal Microbiota Transplantation (FMT) Applied for Chronic Kidney Disease (CKD)
The aim of this PhD project focuses on the relationship between intestinal microbiota and health in the background of Chronic Kidney Disease (CKD).
- Trial name
- NCT04222153
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Fecal Microbiota Transplantation
Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
Fecal microbiota transplantation (FMT), defined as infusion of feces from healthy donors to affected subjects, is a method to restore a balanced gut microbiota and has attracted great interest in recent years due to its efficacy…
- Trial name
- FMT-IBD (NCT04436874)
- Testing
- endoscopy
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Crohn's Disease
Impact of the Fecal Flora Transplantation on Crohn's Disease
Crohn's disease is a chronic and relapsing inflammatory bowel disease. Many data show that the intestinal flora is involved in the disease and it has been show that patients with Crohn's disease exhibit an abnormal fecal flora…
- Trial name
- IMPACT-Crohn (NCT02097797)
- Testing
- Fecal Transplantation
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatic Disorders, Intestinal Failure-associated Liver Disease
VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients
The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease.
- Conditions
- Hepatic Disorders, Intestinal Failure-associated Liver Disease, Cystic Fibrosis Liver Disease, MAFLD
- Trial name
- VALiBi-PED (NCT07202910)
- Where
- Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Gastro-Intestinal Disorder
Healthy Stool Volunteer Donors for Fecal Microbiota Transplantation Trials
Currently, ANSM recommendations govern FMT (Fecal Microbiota Transplantation) in clinical trials. The collection and validation of these stool donations as part of the trials is complex and not very efficient.
- Trial name
- VIOLONSEL (NCT06478823)
- Testing
- Stools donation
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Attention-deficit/Hyperactivity Disorder
Washed Microbiota Transplantation for Attention-deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention and hyperactivity-impulsivity.
- Trial name
- WMT for ADHD (NCT06376331)
- Testing
- washed microbiota transplantation
- Where
- 2 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Ulcerative Colitis, Irritable Bowel Syndrome
Fecal Microbiota Transplantation for Health Improvement (TFM3)
Search for mechanisms of the effect of fecal transplantation on a healthy organism and various nosological forms.
- Conditions
- Ulcerative Colitis, Irritable Bowel Syndrome, Crohn Disease, Irritable Bowel
- Trial name
- TFM3 (NCT04011943)
- Testing
- Fecal Microbiota Transplantation
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Biliary Atresia
Gut Microbiome in Biliary Atresia
The investigator will investigate the gut-microbiome and liver elasticity of the Biliary Atresia (BA)-patients before and after Kasai operation.
- Trial name
- NCT04260503
- Testing
- Monitoring of the gut-microbiome and ultrasound elasticity., Monitoring of the gut-microbiome, Monitoring of the gut-microbiome.
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Inflammatory Bowel Disease, Ulcerative Colitis Type
A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
There are many limitations in the current treatments of Inflammatory bowel disease(IBD). Some patients have no or little reaction to the traditional drugs.
- Trial name
- NCT04521205
- Testing
- fecal microbiota capsule
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University