Clinical trials: Intestinal Transplantation
Carbapenemase-producing Enterobacteriaceae Infection
Clinical Trial to Demonstrate the Effectiveness of Fecal Microbiota Transplantation for Selective Intestinal Decolonization of Patients Colonized by Carbapenemase-producing Klebsiella Pneumoniae
Infections caused by carbapenemase-producing Enterobacteriaceae are frequent and often associated with high rates of mortality. Colonized patients are at increased risk of infection for these microorganisms.
- Trial name
- KAPEDIS (NCT04760665)
- Testing
- Fecal microbiota transplantation
- Where
- Spain
- Volunteers
- 2 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Crohn Disease
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Newly Diagnosed Active Crohn Disease
Dysbiosis can be rectified by several methods: antibiotics, prebiotics, probiotics, dietary modulation, and fecal microbiota transplantation.
- Trial name
- ALTER-CD (NCT06890650)
- Testing
- Fecal Microbial Transplantation, Crohns disease exclusion diet
- Where
- 6 sites in India
- Volunteers
- 168 people
- Sponsor
- All India Institute of Medical Sciences
Irritable Bowel Syndrome
Donor Selection for Faecal Microbiota Transplantation in Irritable Bowel Syndrome
Five hundred patients are randomized 1:1:1:1 into placebo (own feces), or receiving 90 g fecal transplant from donor A, donor B or donor C.
- Trial name
- NCT06171126
- Testing
- Faeces from donor A, Faeces from donor B, Faeces from donor C
- Where
- 3 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Haukeland University Hospital
Crohn Disease, Perianal Fistula
Adipose Tissue in Crohn´s Disease Fistulas
Present study investigated the efficacy of injection of freshly collected autologous adipose tissue into perianal fistulas in patients with Crohn's disease.
- Conditions
- Crohn Disease, Perianal Fistula, Tissue Transplantation
- Trial name
- NCT03803917
- Testing
- Injection with freshly collected autologous adipose tissue
- Volunteers
- 21 people
- Sponsor
- Lilli Lundby
Colorectal Neoplasms, Liver Neoplasms
Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options
Patients whose colorectal cancer has spread to the liver, and whose liver metastases cannot be removed by surgery or destroyed by ablation, currently receive palliative chemotherapy in Germany.
- Conditions
- Colorectal Neoplasms, Liver Neoplasms, Neoplasm Metastases, Colorectal Liver Metastases
- Trial name
- GTO-001 (NCT07811453)
- Testing
- Liver transplantation
- Where
- Germany
- Volunteers
- 260 people
- Sponsor
- Charite University, Berlin, Germany
Hematopoietic Stem Cells
Vedolizumab in the Prophylaxis of Intestinal Acute Graft Versus Host Disease (aGVHD) in Participants Undergoing Allogeneic Hematopoietic Stem Cell (Allo-HSCT) Transplantation
The purpose of this study is to evaluate the efficacy of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal aGvHD-free survival by Day +180 in…
- Trial name
- NCT03657160
- Testing
- Vedolizumab
- Where
- 139 sites in United States, Argentina and 25 more
- Volunteers
- 343 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma
RATIONALE: Bortezomib and azacitidine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Hepatosplenic T-cell Lymphoma
- Trial name
- NCT01129180
- Testing
- azacitidine, bortezomib, Correlative studies
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Pierluigi Porcu
IBD
Regulation of Vitamin D Metabolism by Washed Microbiota Transplantation in Patients With IBD
WMT could effectively induce clinical response and maintain remission in patients with Inflammatory bowel disease (IBD). VD maintains gut microbiota and gut microbiota alter intestinal vitamin D metabolism (VDM),The aim of this…
- Trial name
- NCT04989374
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Crohn Disease
Randomized Trial Comparing Single vs. Maintenance Fecal Microbiota Transplant for Refractory Crohn's Disease in Children
NCT02108821 Primary goal: -To determine the safety of fecal transplant by colonoscopy and retention enemas for induction followed by maintenance retention fecal vs.
- Trial name
- NCT03747718
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Sponsor
- Stanford University
Colonization, Asymptomatic
Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Via Capsules for Intestinal Multidrug-resistant Bacteria Decolonization
The goal of this clinical trial is to learn if oral capsules containing lyophilized stool from healthy donors (fecal microbiota transplantation or FMT) can safely and effectively decolonize multidrug-resistant organisms (MDROs)…
- Trial name
- FORCE (NCT07106580)
- Testing
- lyophilized FMT capsules
- Where
- Croatia
- Volunteers
- 52 people
- Sponsor
- University of Rijeka
Clostridium Difficile Colitis
Stool Transplants to Treat Refractory Clostridium Difficile Colitis
It has been shown that restoration of the normal makeup of the bowel bacterial population is the most effective way to treat recurrent colitis due to Clostridium difficile.
- Trial name
- NCT02127398
- Testing
- fecal microbiota
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Duke University
Small Intestinal Bacterial Overgrowth, Fecal Microbiota Transplantation
Clinical Study of Fecal Microbiota Transplantation in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)
Small intestinal bacterial overgrowth (SIBO) is defined as the presence of excessive numbers of bacteria in the small bowel causing gastrointestinal (GI) symptoms.
- Trial name
- NCT06162702
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai 10th People's Hospital
Acute Graft Versus Host Disease in Intestine
FMT for Pediatric SR-aGVHD
This is a pilot, prospective, non-profit, multicenter, uncontrolled, open-label study to evaluate the safety and feasibility of FMT in patients aged between 3 months and 25 years suffering from acute intestinal GVHD resistant to…
- Trial name
- NCT07602751
- Testing
- Fecal Microbial Transplantation
- Where
- 3 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Crohn Disease, Pediatric Crohns Disease
FMT in Pediatric Crohn's Disease
The goal of this study is to evaluate the safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease who are in remission. Safety will be the primary endpoint and Pediatric Crohn's Disease.
- Trial name
- FMTPCD (NCT03194529)
- Testing
- FMT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Los Angeles
Kidney Transplant Tolerance
Kidney Graft Tolerance KTOL
Prospective experimental study using PBMC from a limited number of adult patients (15) treated at Nantes University Hospital for a kidney transplant from a related living donor.
- Trial name
- KTOL (NCT06271343)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Nantes University Hospital
Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8
Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer
This trial studies the role of the gut microbiome and effectiveness of a fecal transplant on medication-induced gastrointestinal (GI) complications in patients with melanoma or genitourinary cancer.
- Conditions
- Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage IA Cutaneous Melanoma AJCC v8, Clinical Stage IB Cutaneous Melanoma AJCC v8
- Trial name
- NCT03819296
- Testing
- Best Practice, Biospecimen Collection, Endoscopic Procedure
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- M.D. Anderson Cancer Center
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis
Patients with the chronic bowel disease pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- MicroPouch (NCT04100291)
- Testing
- Faecal microbiota transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Enterobacteriaceae Infections, Multi-antibiotic Resistance
FMT to Eradicate Intestinal Colonization by Carbapenem-resistant Enterobacteriaceae
Antibiotic resistance (AR) is a critical public health threat and one of the greatest challenges of the 21st century. In an estimate of 2019, nearly 700.000 infections and 33.000 attributable deaths from multi-drug-resistant…
- Trial name
- FMT_CRE (NCT05791396)
- Testing
- Donor - FMT
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Multi-antibiotic Resistance
Fecal Transplant for MDRO Decolonization
This is a trial designed to determine whether fecal microbiota transplantation (FMT) can eliminate highly drug-resistant bacteria from the intestinal tract of renal transplant patients.
- Trial name
- NCT04181112
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University of British Columbia
Colorectal Cancer Metastatic, Fecal Microbiota Transplantation
Using Healthy Gut Bacteria to Boost Immune Treatment for Advanced Bowel Cancer
This research protocol outlines an exploratory study on the combination of early-life fecal microbiota transplantation (yFMT) with immunotherapy and chemotherapy in patients with microsatellite stable metastatic colorectal cancer…
- Trial name
- NCT07486492
- Testing
- yFMT
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xiamen University