Clinical trials: Intestines
Colorectal Cancer
Navigation From Community to Clinic to Promote CRC Screening in Underserved Populations
The purpose of this study is to test the effectiveness of a two-phase intervention using "community-to-clinic navigators" to guide individuals from an especially hard-to-reach, multicultural, and underinsured population into…
- Trial name
- NCT01853774
- Testing
- Tailored navigation
- Where
- United States
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Microbiome Composition, Microbiome
The Effects of an Oral Nutritional Intervention on the Small Intestine Microbiome
This is a single-center, single-arm study, aiming at enrolling 25 healthy adult participants to evaluate chronic effects of oil. Specifically, we aim to assess the impact on gut microbiome after a one-month intervention with oil.
- Trial name
- NCT07439718
- Testing
- Oil
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Colorectal Cancer, Image
SGM-101 Tumor Targeted Fluorescence Endoscopy in Rectal Polyps With Suspected T1 Adenocarcinoma or High Grade Dysplasia
This will be the first trial investigating whether tumor targeted fluorescence is able to discriminate invasive T1 carcinoma / High grade dysplasia from Low grade dysplasia/normal tissue during endoscopic intraluminal resection.
- Conditions
- Colorectal Cancer, Image, Low Grade Dysplasia of Colon
- Trial name
- SGM-T1 (NCT06280690)
- Testing
- SGM-101
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
Crohn Disease
Efficacy Study of Sargramostim in the Retreatment of Patients Who Have Crohn's Disease Who Have Previously Responded to Treatment With Sargramostim
The purpose of this study is to evaluate whether treatment with Leukine in patients with Crohn's disease who have previously responded to Leukine can be helped again, once they have relapsed.
- Trial name
- NCT00206713
- Testing
- Sargramostim (Leukine)
- Where
- 7 sites in United States
- Volunteers
- 264 people
- Sponsor
- Genzyme, a Sanofi Company
Crohns Disease
Pilot Comparative Bioavailability Study of 6Mercaptopurine (Delayed Release vs. Purinethol) in Crohns Disease Patients
The study is being conducted to evaluate the pharmacokinetic parameters (Cmax, Tmax and AUC) of the new delayed release, lowered dose, 40 mg 6MP test formulation as compared to standard 6MP (100 mg Purinethol) in 12 patients with…
- Trial name
- NCT00774982
- Testing
- Delayed Release 6 mercaptopurine, 6 Mercaptopurine
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Teva GTC
Appendiceal Cancer
Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma
A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly…
- Trial name
- NCT05452382
- Testing
- Partial colecctomy, Hemicolectomy
- Where
- United States
- Volunteers
- 2,607 people
- Sponsor
- Mansoura University
Colorectal Neoplasms, Colonic Polyps
A Novel Clinical Decision Support Tool to Predict Submucosal Invasive Cancer Within Large Non-Pedunculated Colorectal Polyps
Colorectal cancer can be effectively prevented by removal of pre-malignant polyps during colonoscopy. Large (>=20mm) non-pedunculated colorectal polyps (LNPCPs) require careful assessment before treatment.
- Trial name
- NCT07705880
- Where
- Belgium
- Volunteers
- 886 people
- Sponsor
- University Hospital, Ghent
Whipple Disease
Detection and Characteristic of Whipple Diseases in the Great Britany
Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or…
- Trial name
- WHO (NCT03350685)
- Where
- 8 sites in France
- Volunteers
- 267 people
- Sponsor
- University Hospital, Brest
Ulcerative Colitis
Preference for a Prefilled Syringe or Smartject™ Device for Delivering Golimumab in Participants Suffering From Moderate-to-severe Ulcerative Colitis (MK-8259-027)
This study is designed to determine whether ulcerative colitis participants prefer delivery of golimumab via a prefilled syringe or the Smartject™ device.
- Trial name
- SMART (NCT02155335)
- Testing
- Prefilled Syringe delivery of Golimumab, Smartject Device delivery of Golimumab
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
Colonoscopy, Patient Compliance
Evaluation of Information on Bowel Preparation for Morning Colonoscopy
Background: In randomized controlled trials, split-dose bowel preparation for colonoscopy has been shown to provide better bowel cleansing than day before bowel preparation.
- Trial name
- NCT03650725
- Testing
- Mandatory Split bowel preparation
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Harminder Singh
Colorectal Cancer
Phase I / II Study of Irinotecan (CPT-11) Combined With l-Leucovorin (l-LV) and 5-FU in Patients With Advanced Colorectal Cancer
We performed a phase I/II study of CPT-11/5FU/l-LV in advanced colorectal cancer, to determine the optimal dose of CPT-11 and to estimate the safety and efficacy of this regimen
- Trial name
- NCT00209625
- Testing
- irinotecan, leucovorin, fluorouracil
- Where
- Japan
- Volunteers
- 23 people
- Sponsor
- Hokkaido Gastrointestinal Cancer Study Group
Healthy, Adult
Understanding Effects of Calcium on the Gut-Bone Axis
The study team is inviting 13 healthy people to complete a study to explore how calcium affects hormones and bones after eating. Participants will be asked to complete two study visits within eight weeks.
- Conditions
- Healthy, Adult, Calcium, Bone Resorption
- Trial name
- NCT06383117
- Testing
- Calcium carbonate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Rheumatoid Arthritis, Myositis
Rheumatoid Arthritis and Myositis Cohort
The primary objective of this research is to establish a well characterized clinical and longitudinal cohort for individuals with Rheumatoid Arthritis (RA) and Myositis to create a place to maintain blood, urine, stool specimens…
- Trial name
- NCT05627089
- Sponsor
- Attune Health Research, Inc.
Obesity
Trigona Honey and Intestinal Microbiota Among Obese People
Objective : Nutrition intervention is one of the approaches to deal with obesity. Natural honey with its polyphenol component has an impact on the intestinal microbiota and lipid profile.
- Trial name
- NCT04974450
- Testing
- Trigona honey, control
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Irritable Bowel Syndrome
Smartphone Training for Attention Regulation for IBS
In the largest and most well-controlled randomized control trial of mindfulness-based interventions (MBIs) training in irritable bowel syndrome (IBS) to-date (N=360), the investigators will evaluate whether a smartphone MBI…
- Trial name
- NCT05083091
- Testing
- Mindfulness and Attention Training, Mindfulness training, Coping Condition
- Where
- United States
- Volunteers
- 359 people
- Sponsor
- Carnegie Mellon University
Severe Acute Malnutrition, Moderate Acute Malnutrition
Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition
This single-center, randomized, open-label trial will compare the safety of MTT delivered by rectal catheter enema in participants 12-60 months of age with malnutrition (moderate acute malnutrition [MAM] or severe acute…
- Trial name
- THRIVE (NCT03087097)
- Testing
- Fecal Microbiota Transplantation
- Where
- South Africa
- Volunteers
- 5 people
- Sponsor
- Microbiome Health Research Institute
Inflammatory Bowel Diseases, Crohn Disease
Digestive Biobank for Exploring Microbiota-host Interactions
Constitution of a biobank of tissues, whole blood and plasma samples and stools to identify markers associated with treatment response, postoperative morbidity including neuro-cognitive and mood complications and prognosis of…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Colorectal Cancer
- Trial name
- BiomHost (NCT05704413)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
Vagus Nerve Stimulation in Crohn's Disease
This is an open label interventional study using an implantable vagus nerve stimulation device in patients with Crohn's disease who have active disease despite treatment with a tumor necrosis factor (TNF) antagonist drug.
- Trial name
- NCT02311660
- Testing
- Vagus Nerve Stimulation Device
- Where
- 4 sites in Croatia, Italy and 2 more
- Volunteers
- 15 people
- Sponsor
- SetPoint Medical Corporation
Colorectal Cancer
Shared Decision-making and Colorectal Cancer Screening
Conduct a feasibility pilot RCT of a newly developed colorectal cancer screening (CRC) decision aid (DA) including 66 LHL adults 76-85 years recruited from community health centers.
- Trial name
- NCT04748380
- Testing
- CRC decision aid pamphlet, Home Safety Pamphlet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Anal Fistula
Evaluation of the Recovery Rate and Postoperative Incontinence of Surgical Fistulas in a Cohort of a Reference Centre
Fistula is a pathology that can be complex and lead to treatment difficulties for the proctologist. The proctologist's objective is to treat the infection (anal fistula and abscess) with the minimum impact on anal continence.
- Trial name
- PROFIL (NCT03865823)
- Testing
- pus sample
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
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