Clinical trials: Intraabdominal Infections
Abdominal Sepsis, Critically Ill
Blood Indices of Systemic Inflammation in Critically Ill Patients With Abdominal Sepsis
This study aims to clarify the role of blood indices of systemic inflammation in ICU-admitted patients with abdominal sepsis to assess their diagnostic significance as well as their prognostic value.
- Trial name
- NCT06095830
- Testing
- Complete blood count
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Common Bile Duct Injury
Post-cholecystectomy Major Bile Duct Injury
Bile duct injury (BDI) is one of the devastating recognized complications of cholecystectomy which does not respect the seniority or experience of the surgeon.
- Trial name
- NCT05436626
- Testing
- Early BDI reconstruction without abdominal sepsis control, Early BDI reconstruction with abdominal sepsis control, Delayed reconstruction
- Volunteers
- 277 people
- Sponsor
- South Valley University
Necrotizing Enterocolitis, Intra-abdominal Infection
Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections
Meropenem is an antibiotic that is commonly used to treat serious infections. Although it is used in premature and young infants, the correct dose is not known.
- Trial name
- NCT00621192
- Testing
- meropenem
- Where
- 26 sites in United States
- Volunteers
- 200 people
- Sponsor
- The Emmes Company, LLC
Abdominal Sepsis, Acute Respiratory Failure
Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis.
- Conditions
- Abdominal Sepsis, Acute Respiratory Failure, Ventilation Therapy; Complications, Emergencies
- Trial name
- CHESTOMY (NCT05726500)
- Testing
- Arterial blood gas analysis, Venous blood gas analysis, Esophageal pressure monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Intra Abdominal Infections, Candidiasis, Invasive
Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2)
New rapid diagnostic strategies are warranted in intra-abdominal candidiasis (IAC). A previous retrospective study showed that one measure, the day of the surgery, of peritoneal 1.3-Beta-D-Glucan ≤ 310pg/ml could rule out an IAC.
- Conditions
- Intra Abdominal Infections, Candidiasis, Invasive, Peritoneal Candidiasis, Critically Ill
- Trial name
- pBDG2 (NCT03997929)
- Testing
- 1.3 BETA D GLUCAN
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Abdominal Sepsis, Abdominal Infection
Closed or Open Abdomen for the Management of Abdominal Sepsis
This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED); or B) leave the fascia open after…
- Trial name
- NCT03163095
- Testing
- Open Abdomen Management with ANPPT dressing, Closed Abdomen Management
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- University of Calgary
Gut Microbiota, Intra-abdominal Infections
Gut Microbiota Analysis in IAI Patients With Sepsis-associated Liver Dysfunction
With the rapid development of intensive care medicine, the mortality of patients with sepsis has decreased over the past decade, but it is still the leading cause of death in intensive care unit (ICU).
- Conditions
- Gut Microbiota, Intra-abdominal Infections, Acute Gastrointestinal Injury, Sepsis-associated Liver Dysfunction
- Trial name
- 2022-11-09 (NCT05628493)
- Testing
- Gut microbiota Analysis
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese Medical Association
Postoperative Infection, Abdominal Surgery
Study for Rapid Diagnosis of Postoperative Abdominal Infection
This is a prospective and exploratory study, which utilizes non-targeted metagenomic next-generation sequencing (mNGS) detecting drain fluid from patients who are suspected of postoperative abdominal infection.
- Conditions
- Postoperative Infection, Abdominal Surgery, Intra-abdominal Infection, Postoperative Fever
- Trial name
- NCT05187871
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Urinary Tract Infections, Pyelonephritis Acute
Safety, Tolerability, and Pharmacokinetics of Sulopenem in Adolescents
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of intravenous sulopenem and oral sulopenem etzadroxil/probenecid in adolescent patients.
- Conditions
- Urinary Tract Infections, Pyelonephritis Acute, Intraabdominal Infections
- Trial name
- NCT04700787
- Testing
- Sulopenem
- Where
- United States
- Sponsor
- Iterum Therapeutics, International Limited
Severe Traumatic Brain Injury, Pancreatic Diseases
The Effect of Closed Suction System on the Incidence of Ventilator-associated Pneumonia.
The investigators are suggesting that closed suction systems may reduce the risk of the ventilator - associated pneumoniae (VAP) and the contamination of the closest unanimated surfaces. In 2011 David et al.
- Conditions
- Severe Traumatic Brain Injury, Pancreatic Diseases, Trauma Injury, Seizures
- Trial name
- CSS-VAP (NCT04323150)
- Testing
- Closed suction systems, Conventional suction system
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Abdominal Trauma, Abdominal Injury
A Non-Traumatic Binder for Temporary Abdominal Wall Closure
At the end of most abdominal operations, the fascial layer is closed by stitching edges of the wound together. However, because of logistic and/or technical reasons or the patient's critical condition, the surgeon is forced to…
- Conditions
- Abdominal Trauma, Abdominal Injury, Abdominal Infection, Abdominal Sepsis
- Trial name
- ABRO (NCT03815370)
- Testing
- Experimental: ABRO™ Binder Arm
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Appendicitis, Other and Unspecified Acute Appendicitis
The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis and BMI >30
This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis.
- Conditions
- Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Disease
- Trial name
- OPTICAP>30 (NCT04519086)
- Testing
- Low-dose CT, Laparoscopic appendectomy
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Intraabdominal Abscess After Procedure, Leakage
Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation
Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal…
- Conditions
- Intraabdominal Abscess After Procedure, Leakage, Pneumonia, Operation Wound; Infection
- Trial name
- NCT05147870
- Testing
- Peritoneal irrigation, Suction only
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Wei-Jung
Respiratory Tract Infections, Urinary Tract Infections
HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study
This study will analyze gene expression data (HostDx Sepsis test) from blood samples collected from participants with suspected infections.
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Skin and Soft Tissue Infections, Intraabdominal Infections
- Trial name
- NCT03744741
- Testing
- HostDx Sepsis
- Where
- 7 sites in United States, Greece
- Volunteers
- 585 people
- Sponsor
- Inflammatix
Intra-Abdominal Infections
Procalcitonin Guided Antibiotic Therapy
The overuse of antibiotics is an enormous problem facing the healthcare system both in the United States and across the world. The investigators plan to test the hypothesis that using procalcitonin levels (blood test) to guide…
- Trial name
- NCT04240288
- Testing
- Procalcitonin-guided antibiotic treatment, Standard of Care Antibiotic Treatment
- Sponsor
- Columbia University
Acute Kidney Injury, Peritonitis
Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury
Phase 3 multicenter study to be conducted in up to 90 qualified participating sites globally to assess the efficacy and safety of Reltecimod vs placebo in patients with sepsis-associated Stage 2/3 AKI.
- Conditions
- Acute Kidney Injury, Peritonitis, Necrotizing Soft Tissue Infection
- Trial name
- NCT03403751
- Testing
- Reltecimod 0.5 mg/kg
- Where
- 56 sites in United States, France
- Volunteers
- 58 people
- Sponsor
- Atox Bio Ltd
Intra-abdominal Infections
LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Intra-abdominal Infection (cIAI)
The purpose of the study was to evaluate whether LYS228 can be developed for the treatment of complicated intra-abdominal infections.
- Trial name
- NCT03354754
- Testing
- LYS228, Standard of care therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Abdominal Sepsis
Assessment of Peritoneal Immune Response in Patients With Severe Intra-abdominal Sepsis Managed With Laparostomy and Vacuum Assisted Closure (VAC)
Protocol Synopsis Protocol title: Assessment of peritoneal immune response in patients with severe intra-abdominal sepsis managed by laparostomy and VAC Purpose: Assessment of peritoneal immune response in patients with severe…
- Trial name
- NCT01410526
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Bacterial Infection, Postoperative Infection
Neutrophil CD64 and Procalcitonin as Novel Biomarkers for Postoperative Infections
Postoperative complications, especially bacterial infections, are relatively common and cause increased morbidity and mortality.
- Conditions
- Bacterial Infection, Postoperative Infection, Abdominal Infection
- Trial name
- NCT01250574
- Testing
- CD64 and Procalcitonin
- Where
- Norway
- Volunteers
- 173 people
- Sponsor
- University Hospital, Akershus