Clinical trials: Intracranial CNS Disorder
Early Onset Alzheimer Disease, Alzheimer Disease
Longitudinal Early-onset Alzheimer's Disease Study Protocol
The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment.
- Conditions
- Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- LEADS (NCT03507257)
- Testing
- Flortaucipir, Florbetaben, Fluorodeoxyglucose
- Where
- 23 sites in United States, Argentina and 4 more
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alzheimer's Disease, Lewy Body Dementia
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.
- Conditions
- Alzheimer's Disease, Lewy Body Dementia, Parkinson's Disease
- Trial name
- NCT03019757
- Testing
- DaTscan, F18-AV-45, FDG-PET
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Douglas Scharre
Mild Cognitive Impairment, Memory Disorders
Behavioral Interventions to Prevent or Delay Dementia
This study will compare the effectiveness of different combinations of 5 types of behavioral interventions across patient-centered outcomes. It will also evaluate which outcomes (e.g.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Mild Dementia, Impaired Cognition
- Trial name
- NCT02265757
- Testing
- Cognitive Rehabilitation, Computer Brain Fitness Training, Support Group (patient and partner)
- Where
- 3 sites in United States
- Volunteers
- 272 people
- Sponsor
- Mayo Clinic
IIH - Idiopathic Intracranial Hypertension
Current Treatment Methods of Idiopathic Intracranial Hypertension
Aim of the study : 1. to determine the response to each treatment plan. 2. to determine when to choose specific treatment method. 3. to determine complication of each type of treatment method
- Trial name
- NCT06353412
- Testing
- Lumbar puncture
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Huntington's Disease
Randomized, Placebo Controlled Study Of The Efficacy And Safety Of PF-02545920 In Subjects With Huntington's Disease
This study is a 26 week, randomized, parallel group, double blind comparison of PF-02545920 5 mg, PF-02545920 20 mg, and placebo dosed BID in the treatment of motor impairment of subjects with Huntington's Disease.
- Trial name
- NCT02197130
- Testing
- PF-02545920
- Where
- 57 sites in United States, Canada and 3 more
- Volunteers
- 272 people
- Sponsor
- Pfizer
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Cerebral Vasospasm
At present, cerebral vasospasm (cVS) is the main cause of delayed cerebral infarction (DCI), which leads to high disability and mortality rate after aneurysmal subarachnoid hemorrhage.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Cerebral Vasospasm
- Trial name
- BLOCK-CVS (NCT04691271)
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Beijing Tiantan Hospital
Unilateral Cerebral Palsy
Wereables for Upper Limb Functionality in Hemiparesis
The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of…
- Trial name
- WeFun (NCT06872736)
- Testing
- WeFun-wearable activated, WeFun-wearable desactivated
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidade da Coruña
Depression
Personalized Prevention of Depression in the Workplace (e-pD-Work)
The main goal is to design, develop and evaluate a personalized intervention to prevent depression in the workplace, based on Information and Communication Technologies (ICTs), predictive risk algorithms and decision support…
- Trial name
- e-pD-Work (NCT04858737)
- Testing
- e-predictD-Work intervention, Brief psychoeducational messages
- Where
- Spain
- Volunteers
- 1,054 people
- Sponsor
- The Mediterranean Institute for the Advance of Biotechnology and Health Research
Stroke, Stroke Rehabilitation
Optimization of Time Parameters of Priming iTBS for Poststroke Motor Rehabilitation
The goal of this clinical trial is to identify the effect of different time intervals between continuous theta burst stimulation (cTBS) and intermittent theta burst stimulation(iTBS), on top of a standard robot-assisted training…
- Trial name
- TMS (NCT06612437)
- Testing
- continuous theta burst stimulation (cTBS), intermittent theta burst stimulation (iTBS), Robot-assisted training
- Where
- 2 sites in Hong Kong
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Intracranial Pressure, Brain Injuries, Traumatic
Correlation Patterns of Brain Temperature-Pressure in Acute Brain Injury
The goal of this prospective, multicenter, observational, cohort trail is to explore the pattern of brain temperature-brain pressure association in acute brain injury and to clarify its predictive value for prognosis and…
- Conditions
- Intracranial Pressure, Brain Injuries, Traumatic, Subarachnoid Hemorrhage, Cerebral Hemorrhage
- Trial name
- MERCURY (NCT06101537)
- Testing
- Brain temperature-pressure monitoring
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease
Phosphorylation of ERK1/2 in Patients With Parkinson's Disease
Levodopa-induced dyskinesia severely limits the use of levodopa in Parkinson's disease and constitutes a debilitating complication of dopaminergic treatment in late stage.
- Trial name
- BIODYS (1) (NCT01142739)
- Testing
- Clinical variables
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Migraine With Aura, Migraine Without Aura
Tailored Digital Treatment for Migraine
Background: An individualized internet-based treatment program from a biopsychosocial perspective has been developed within the Västra Götaland region (VGR) with funds from the Innovation Fund.
- Trial name
- NCT05617339
- Testing
- I am (internet approach to migraine)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Vastra Gotaland Region
Aging, Stroke
Precision Vibration Therapy for Neuromuscular and Functional Improvement in Older Adults and Stroke Survivors
To address muscle weakness, sensory degradation, functional decline, and pain caused by geriatric syndromes in older adults and stroke survivors, this project proposes a series of studies aimed at improving neuromuscular…
- Trial name
- NCT07351877
- Testing
- Precision Vibration Therapy, Conventional Rehabilitation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Health Research Institutes, Taiwan
Metastatic Rectal Adenocarcinoma, Brain Metastases
BRIANSTORM - Early Identification of Patients With Brain Metastases
A single arm observational study investigating the incidence of brain metastasis in patients with cancer recti and lung metastasis
- Trial name
- NCT05185557
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Stroke, Hemiparesis
Electrical Stimulation for Recovery of Hand Function in Chronic Stroke Survivors
Impaired hand function is one of the most frequently persisting consequences of stroke. The purpose of this study is to compare two different treatments -- Contralataterally Controlled Functional Electrical Stimulation (CCFES)…
- Conditions
- Stroke, Hemiparesis, Hemiplegia
- Trial name
- NCT00891319
- Testing
- Electrical stimulator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- MetroHealth Medical Center
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Stroke
Vestibular Training on Community Ambulation and Fall Risk in Stroke
Nearly half of individuals with stroke experience limitations in community ambulation, and 35.7% of community-dwelling stroke survivors experienced falls while walking, indicating that falls are common during routine daily…
- Trial name
- NCT07494500
- Testing
- Vestibular training, Conventional physical therapy
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Yang Ming Chiao Tung University
Cerebral Palsy
Robot Based Gait Training Therapy for Pediatric Population With Cerebral Palsy Using the CPWalker
This trial is being conducted to determine if the CPWalker can be used as a gait training intervention for pediatric patients with gait impairments due to cerebral palsy
- Trial name
- NCT03937700
- Testing
- CPWalker Robotic Exoskeleton
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Gilles de la Tourette's Syndrome
Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome
Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders…
- Trial name
- NCT00664300
- Testing
- Facial expression recognition of emotion
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Ischemic Stroke
Early Mobilization of Ischemic Stroke Patients Within 24-hours After Intravenous-Tissue Plasminogen Activator (IV-tPA)
The purpose of this study is to study the safety and feasibility of mobilization of acute ischemic stroke patients treated with IV-tPA between 12-24 hours of treatment.
- Trial name
- EMISTPA (NCT01331200)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic