Clinical trials: Intracranial Hemorrhages
Cerebral Hemorrhage
Decompressive Hemicraniectomy in Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) remains a devastating disease with mortality rates up to 52% at 30 days. It is a major public health problem with an annual incidence of 10-30 per 100'000 population, accounting for 2…
- Trial name
- SWITCH (NCT02258919)
- Testing
- Decompressive craniectomy (DC) and best medical treatment, Best medical treatment
- Where
- 32 sites in Austria, Belgium and 6 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertension, Hemorrhage
Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE)
The purpose of this study was to determine the efficacy and safety of clevidipine for treating acute hypertension (high blood pressure, defined as systolic blood pressure >160 mmHg) in patients with intracerebral hemorrhage…
- Trial name
- ACCELERATE (NCT00666328)
- Testing
- clevidipine
- Where
- 17 sites in United States, Germany
- Volunteers
- 37 people
- Sponsor
- The Medicines Company
Hematoma, Subdural, Chronic
Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma
Rationale: Chronic subdural hematoma (cSDH) is a frequently occurring disease, occurring mainly in the elderly. Surgical evacuation is effective, but also associated with life-threatening risks.
- Trial name
- TORCH (NCT03582293)
- Testing
- Tranexamic Acid 500Mg Tablet
- Where
- Netherlands
- Volunteers
- 554 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Subarachnoid Hemorrhage, Aneurysmal, Cerebrovascular Disorders
Safety , Feasibility and Preliminary Efficacy of Remote Ischemic Conditioning in Patients With Aneurysmal Subarachnoid Hemorrhage After Aneurysm Clipping
This study was designed to evaluate the safety and efficacy of remote ischemic conditioning (RIC) in patients with aneurysmal subarachnoid hemorrhage (aSAH) following surgical clipping.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrovascular Disorders, Brain Diseases, Stroke
- Trial name
- NCT06819657
- Testing
- Remote Ischemic Conditioning Treatment Instrument, Guideline-based therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
TaVNS for Acute Intracerebral Hemorrhage
This study aims to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with acute intracerebral hemorrhage (ICH).
- Trial name
- TAVANS-ICH (NCT06918964)
- Testing
- transcutaneous auricular vagus nerve stimulation device
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
Satralizumab in Aneurysmal Subarachnoid Hemorrhage
In this study, satralizumab will be administered to see whether satralizumab is safe in patients with a burst brain aneurysm and if it may prevent strokes in patients with a burst brain aneurysm.
- Trial name
- SASH (NCT05727657)
- Testing
- Satralizumab
- Where
- United States
- Sponsor
- University of Florida
Intracerebral Hemorrhage
Simvastatin For Intracerebral Hemorrhage Study
Study Objective: To analyze if statins are effective in ameliorating perihematomal edema evolution thereby reducing mortality and improving functional outcomes following spontaneous intracerebral hemorrhage (ICH).
- Trial name
- NCT00718328
- Testing
- Simvastatin 80 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Intracerebral Hemorrhage
AI-Guided Hematoma Aspiration vs. Conservative Treatment for Spontaneous ICH
The effectiveness of traditional craniotomy in the treatment of intracerebral hemorrhage remains controversial. Minimally invasive surgery, specially, image-guided hematoma aspiration, proves to be effective and may have some…
- Trial name
- NCT07077343
- Testing
- AI-Assisted Navigated Hematoma Aspiration, Conservative Treatment
- Where
- China
- Volunteers
- 680 people
- Sponsor
- Xiaolei Chen
Intracranial Hemorrhages, Traumatic Brain Injury
Evaluate the SENSE Device's Ability to Monitor and Detect Intracranial Hemorrhage
This study is a two-stage, pivotal, prospective, non-randomized, multi-center, within patient comparison of the SENSE device and the standard diagnostic test, head CT scan in patients with a diagnosis of primary spontaneous ICH…
- Trial name
- NCT04642443
- Testing
- SENSE Device
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Sense Diagnostics, LLC
Intracerebral Hemorrhage
Vitamin D for Acute Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is the most deadly and debilitating form of stroke. To date, effective treatment that could improve the functional outcome of ICH remained elusive.
- Trial name
- VICToHR (NCT07458815)
- Testing
- Vitamin D
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Traumatic Brain Hemorrhage
SAFETY: Stabilization Points to Third Hospital Line Assessment oF the Impact of the usE of Infrascanner Model 2500 to Provide Decision Support for Diagnosis/Screening of Traumatic Brain InjurY in Ukraine
The Infrascanner model 2500 is a handheld, noninvasive device that is FDA-cleared to detect traumatic intracranial hematomas. FDA clearance K200203 was issued in 2020, K211617 added pediatric age group to the IFU in 2022, and…
- Trial name
- SAFETY (NCT07014748)
- Testing
- Handheld brain hematoma detector
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 600 people
- Sponsor
- InfraScan, Inc.
Aneurysmal Subarachnoid Hemorrhage
A Safety and Efficacy Study of NicaPlant® in Aneurysmal Subarachnoid Haemorrhage Patients Undergoing Aneurysm Clipping
This study of NicaPlant® is conducted in patients who have a subarachnoid haemorrhage. Patients will be randomized in two treatment groups.
- Trial name
- NCT04269408
- Testing
- Nicardipine, Standard of care
- Where
- 6 sites in Austria, Germany
- Volunteers
- 41 people
- Sponsor
- BIT Pharma GmbH
Cerebral Vasospasm, Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation in Patients With Cerebral Vasospasm After Subarachnoid Haemorrhage: VasoStim Study
Cerebral vasospasm is characterized by a vasoconstriction of cerebral arteries causing a reduction of cerebral blood flow (CBF) and leading to ischemia and infarction of the brain parenchyma.
- Trial name
- NCT05150002
- Testing
- Spinal cord stimulation
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intracerebral Hemorrhage
Dose Finding and Safety Study of Deferoxamine in Patients With Brain Hemorrhage
Animal studies show that the breakdown of blood results in iron accumulation in the brain after brain hemorrhage (ICH); and that iron plays a role in brain injury in ICH patients.
- Trial name
- DFO In ICH (NCT00598572)
- Testing
- Deferoxamine Mesylate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Subarachnoid Hemorrhage
Quantification of Cerebral Blood Flow by Arterial Spin Labeling in Vasospasm in Subarachnoid Haemorrhage
A technique of MRI infusion -l'Arterial Spin Labeling-, non-invasive and non-irradiating, repeatable over time, appears promising in the field.
- Trial name
- ASL-HSA (NCT02557607)
- Testing
- MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Hemorrhage Brain
Delayed Intracranial Hemorrhages in Patients With Minor Head Injury on Anticoagulant or Dual Anti-platelet Therapy
Retrospective observational study on a cohort of 2 years to evaluate the incidence of brain hemorrhage present at control head CT scan executed after routine 24h observation period of ED stay in patients with minor head injury on…
- Trial name
- NCT07631936
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Lung Infection, Cerebral Hemorrhage
Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage
This study will determine if rhubarb will reduced the incidence of pneumonia and improved recovery from an acute cerebral hemorrhage.
- Conditions
- Lung Infection, Cerebral Hemorrhage, Pneumonia
- Trial name
- NCT00815737
- Testing
- rhubarb
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Intracerebral Hemorrhage
Prospective Cohort Study of Intracerebral Hemorrhage
The investigators design a prospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalised adult…
- Trial name
- POSTER (NCT04707105)
- Where
- China
- Volunteers
- 856 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Hemorrhage
Diagnostic Utility of MRI in Intracerebral Hemorrhage
The overall aim of this project is to prospectively determine whether MRI can improve the conventional neuroradiological evaluation (CT with or without cerebral angiography) of patients with a spontaneous ICH or IVH.
- Trial name
- DASH (NCT00363662)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital