Clinical trials: Intracranial Pathology
Stroke, Intracerebral Haemorrhage
Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors
The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors.
- Conditions
- Stroke, Intracerebral Haemorrhage, Ischemic Stroke, TIA (Transient Ischemic Attack)
- Trial name
- NCT07414732
- Testing
- Savvy Medication Adherence Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Stroke, Hemiplegia
Relationship Between Clinical Status and Nerve Conduction Test Findings in Patients With Unilateral Hemiplegia
Stroke-related hemiplegia may be accompanied by peripheral nerve conduction abnormalities, which may contribute to motor impairment and functional limitations.
- Conditions
- Stroke, Hemiplegia, Intracranial Hemorrhage, Spontaneous
- Trial name
- NCT07685691
- Testing
- Nerve Conduction Study
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Baskent University
Basal Ganglia Intracerebral Hemorrhage
Minimally Invasive Neuroendoscopic Ultra-Early Targeted ICH Evacuation
MINUTE is a prospective, multi-center, randomized, controlled, blinded assessor, adaptive enrichment design, clinical trial. Eligible patients with spontaneous BGH ≥20 mL will be randomized 1:1 to either minimally invasive…
- Trial name
- MINUTE (NCT07260916)
- Testing
- Endoscopic ICH evacuation, Standard Medical Treatment
- Where
- 44 sites in United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Brain Injuries, Brain Trauma
Evaluation of qSOFA in Neurosurgical Patients
The aim of the study is to look if Quick Sequential Organ Failure Assessment Score score in detecting a eary Sepsis is afflicted by neurosurgical disorders
- Conditions
- Brain Injuries, Brain Trauma, Subarachnoid Hemorrhage
- Trial name
- NCT04265404
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Multimodal Neuromonitoring
Theoretical Framework \& Background Cortical spreading depressions (CSD) and seizures, are crucial in the development of delayed cerebral ischemia and poor functional outcome in patients suffering from acute brain injuries such…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Traumatic Brain Injury, Cortical Spreading Depolarization and Depression
- Trial name
- MMNM (NCT04737369)
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Ascorbic Acid, Neurosurgical Procedures
Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery
The goal of this clinical trial is to investigate the effect of perioperative administration of vitamin C on postoperative pulmonary complications, with the aim of providing a safe and effective medication regimen for the…
- Conditions
- Ascorbic Acid, Neurosurgical Procedures, Humans, Ventilator-Induced Lung Injury
- Trial name
- NCT06421688
- Testing
- Ascorbic acid, Saline
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qianfoshan Hospital
Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic
Interest of Real Time Measurement of Autonomous Nervous System for the Detection of Brain Death
Context: A major lack of organ donors is a serious public health problem. It determines a prolonged delay before a transplant can be performed and thus a significant number of deaths of patients waiting for transplantation.
- Conditions
- Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic, Traumatic Brain Hemorrhage, Traumatic Brain Injury
- Trial name
- MEANS (NCT00918970)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Herpes Zoster, Dementia
Postherpetic Neuralgia After Herpes Zoster and Incident Dementia Risk
This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an…
- Conditions
- Herpes Zoster, Dementia, Postherpetic Neuralgia (PHN)
- Trial name
- NCT07399288
- Testing
- Exposure: postherpetic neuralgia
- Where
- Taiwan
- Volunteers
- 73,404 people
- Sponsor
- China Medical University Hospital
Intracranial Embolism, Thrombosis
Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion
The purpose of the present, randomized, controlled multicenter phase III trial is to investigate the safety and efficacy of continuous 1-hour insonation of occluded middle cerebral artery with 2 MHz TCCS in stroke patients…
- Trial name
- NCT00336596
- Testing
- transcranial ultrasound in patients treated with iv t-PA
- Where
- 6 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Cerebral Hemorrhage, Cerebral Edema
Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study
The goal of this study is to preliminarily determine/estimate feasibility and whether frequent and early conivaptan use, at a dose currently determined to be safe (i.e., 40mg/day), is safe and well-tolerated in patients with…
- Conditions
- Cerebral Hemorrhage, Cerebral Edema, Intracerebral Hemorrhage, Stroke
- Trial name
- NCT03000283
- Testing
- Conivaptan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jesse Corry
Subarachnoid Hemorrhage, Stroke
Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH
This study compares the bioavailability of IV and PO acetaminophen in both blood and the cerebrospinal fluid (CSF) of patients following subarachnoid hemorrhage.
- Trial name
- aSAH (NCT02549716)
- Testing
- IV acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Brain Injury, Traumatic Brain Injury
Connectivity and Neural Signatures of Consciousness in Unresponsive States
The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Consciousness Disorders, Seizures
- Trial name
- CONSCIUS (NCT06426615)
- Testing
- Intracranial electrodes
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Brain Injury Traumatic Mild, Brain Injuries
Screening Emotions in Adolescents at the Hospital for mTBI
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing…
- Conditions
- Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage
- Trial name
- SEARCH-mTBI (NCT06370520)
- Testing
- Validated Questionnaires, Questionnaires, Clinician / Medical Record Variables
- Where
- 6 sites in United States
- Volunteers
- 2,592 people
- Sponsor
- University of California, Davis
Subarachnoid Haemorrhage (SAH), Delayed Cerebral Ischemia
Metabolomics in Subarachnoid Hemorrhage
The goal of this observational study is to learn whether blood and cerebrospinal fluid markers, combined with clinical, imaging and brain monitoring data, can help predict the outcome of adults with spontaneous subarachnoid…
- Trial name
- NeuroMetas (NCT07865182)
- Testing
- Blood and cerebrospinal fluid sampling
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Unidade Local de Saude Sao Jose
Aneurysm, Hypothermia
Hypothermia During Intracranial Aneurysm Surgery Trial
This is a large multi-center, prospective, randomized trial designed to determine whether mild intraoperative hypothermia results in improved neurological outcome in patients with an acute subarachnoid hemorrhage (SAH) who are…
- Conditions
- Aneurysm, Hypothermia, Subarachnoid Hemorrhage
- Trial name
- NCT00029133
- Testing
- mild intraoperative hypothermia (33 degrees Celsius)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Aneurysmal Subarachnoid Hemorrhage, Hyperchloremia
Impact of Multiple Electrolytes Injection Ⅱ and Saline on Hyperchloremia in Patients With Aneurysmal Subarachnoid Hemorrhage:a Pilot Study
The goal of this pilot randomized trial is to compare the effect of Multiple Electrolytes Injection Ⅱand saline on the occurrence of hyperchloremia within 72h of randomization in patients with aneurysmal subarachnoid…
- Trial name
- NCT06076590
- Testing
- maintenance fluid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Alzheimer's Disease, Vascular Dementia
Personalized Music Therapy and Agitation in Dementia
Symptoms of agitation include abuse or aggressive behaviour toward self or others, appropriate behaviour performed with inappropriate frequency, or behaviours that are inappropriate according to social standards.
- Trial name
- NCT02147652
- Testing
- Personalized music
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System
CADASIL
Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASIL
Cerebral small vessel diseases (cSVD) are diseases of brain tissue involving vessels (arterioles or capillaries) with a diameter of less than 400 microns.
- Trial name
- fMRI BioSVD (NCT06859658)
- Testing
- Functional MRI at 3T
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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