Clinical trials: Intracranial Stenosis
Intracranial Atherosclerotic Disease (ICAD), Intracranial Arterial Stenosis
Photon-counting CT for Intracranial Stent Assessment
Intracranial atherosclerotic disease is an important cause of ischemic stroke, and intracranial stent implantation is increasingly used for patients with severe stenotic lesions.
- Conditions
- Intracranial Atherosclerotic Disease (ICAD), Intracranial Arterial Stenosis, Stent Restenosis, Ischemic Stroke
- Trial name
- NCT07769814
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xin Lou
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI
TAVI is increasingly adopted as standard treatment for many subgroups of patients with aortic stenosis. However, due to a lack of data there is yet no TAVI-specific guidance regarding the optimum periinterventional drug regimen.
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, Intracranial Embolism
- Trial name
- DAPT-TAVI (NCT03001960)
- Testing
- Preloading before TAVI, Postloading after TAVI
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Prospective, Multicenter, Randomized, Controlled, and Superior Efficiency
Clinical Trial of Safety and Efficacy of Intracranial Laser Balloon Dilation Catheter in Patients With Symptomatic Intracranial Atherosclerotic Stenosis: A Prospective, Multi-center, Randomized Comparison
Experimental group：Name of Medical Apparatus ：Intracranial Laser Balloon Dilation Catheter and Laser Generator Manufacturer：Hangzhou Juzheng Medical Technology limited company
- Trial name
- Laser balloon (NCT06950242)
- Testing
- Balloon dilation treatment for intracranial arterial stenosis in order to improve intracranial blood supply., Boston Scientific Corporation
- Where
- China
- Volunteers
- 128 people
- Sponsor
- The First People's Hospital of Changzhou
Carotid Stenosis
Diabetes and Risk of Ischemic Stroke.
Diabetes in an independent risk factor for ischemic stroke, whose associated mortality rate is higher and sequelae more serious than for nondiabetics.
- Trial name
- NCT06401902
- Testing
- carotid clamping
- Where
- France
- Volunteers
- 3,739 people
- Sponsor
- Institut Mutualiste Montsouris
Stroke, Transient Ischemic Attack
Angiogenic Markers in Cerebrovascular Disease (ANFIS)
Intracranial atherosclerosis (ICAS) is the most common cause of stroke worldwide. It carries a worse prognosis than other stroke etiologies, with an annual rate of recurrent stroke and death of 15% despite intensive medical…
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Intracranial Arterial Stenosis
- Trial name
- ANFIS (NCT04240119)
- Testing
- According to current clinical care standards
- Volunteers
- 300 people
- Sponsor
- Cedars-Sinai Medical Center
Intracranial Atherosclerosis, Stroke, Ischemic
Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis
One important mechanism of action of GLP1 RA is the improvement in endothelial function, which may be evaluated by the assessment of cerebral vasodilatory reserve (CVR) in patients with severe ICAD.
- Trial name
- RADIANT (NCT07282041)
- Testing
- Dulaglutide
- Where
- Singapore
- Volunteers
- 130 people
- Sponsor
- National University of Singapore
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Arterial Stenosis
Intracranial Arterial Stenosis in Young Patients
The goal of this study is to evaluate the characteristic of intracranial arterial stenosis among young patients.
- Trial name
- ICAS-Young (NCT05844176)
- Testing
- Routine clinical treatment
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
Ischemic Stroke, Carotid Stenosis
STAND: iSchemic sTroke evAluated at Bed Side With ultrasouND
Ischemic strokes account for more than 80% of strokes. Ischemic strokes are caused by the occlusion of an intracranial artery by a thrombus, responsible for tissue ischemia related to a decrease in local cerebral blood flow…
- Trial name
- STAND (NCT04180826)
- Testing
- Observational
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischemic Stroke
Registry Study of Stenting for Symptomatic Intracranial Artery Stenosis in China
The SAMMPRIS suggested that aggressive treatment was superior to intravascular stenting in patients with severe symptomatic intracranial atherosclerotic stenosis (ICAS) due to high complication rate in patients in stenting group.
- Trial name
- NCT01968122
- Testing
- intravascular stent therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongrong Miao
Large Vessel Occlusion, Intracranial Artery Occlusion With Cerebral Infarction
Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis
The study is a prospective multicentre registry study. Patients admitted to 10 stroke centres nationwide from September 2022 to September 2025 with acute ischaemic stroke due to large vessel occlusion considering underlying ICAS…
- Conditions
- Large Vessel Occlusion, Intracranial Artery Occlusion With Cerebral Infarction, Endovascular Treatments, Acute Ischemic Stroke
- Trial name
- NCT06260969
- Testing
- balloon dilatation
- Where
- China
- Volunteers
- 470 people
- Sponsor
- Tianjin Huanhu Hospital
Intracranial Atherosclerosis ICAS
Moderate Versus Intensive Lipid-lowering for Events in Asymptomatic Intracranial Stenosis
It is designed to compare two different strengths of cholesterol-lowering treatment in patients who have narrowing of blood vessels inside the brain (intracranial atherosclerosis) but do not currently have symptoms such as…
- Trial name
- MILES (NCT07791823)
- Testing
- Lipid Lowering Treatment
- Where
- South Korea
- Volunteers
- 1,626 people
- Sponsor
- Woo-Keun Seo
Intracranial Aneurysm
Nomogram for Predicting In-stent Stenosis After Pipeline Embolization Device Treatment in Patients With Intracranial Aneurysm
Intracranial aneurysms (IAs) are the primary cause of non-traumatic subarachnoid hemorrhage with high morbidity and mortality. Flow diverters, such as pipeline embolization devices (PEDs), are among the most effective methods for…
- Trial name
- PED-ISS (NCT06715930)
- Testing
- Interventional treatment
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Stenosis
AcandiS Stenting of Intracranial STENosis - regisTry
ASSISTENT is designed to collect comprehensive information on technical and clinical safety of the use of Credo® stent together with the NeuroSpeed® PTA balloon catheter in clinical practice in an open registry.
- Trial name
- ASSISTENT (NCT03902444)
- Testing
- Credo® Stent, NeuroSpeed® PTA balloon catheter
- Where
- 16 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Acandis GmbH
Intracranial Atherosclerotic Stenosis
High-resolution Magnetic Resonance Vessel Wall Imaging of Plaques
The primary objective of this study is to investigate the predictive value of High-resolution magnetic resonance vessel wall imaging for future stroke occurrence in patients with moderate to severe intracranial and extracranial…
- Trial name
- NCT07125339
- Where
- China
- Volunteers
- 605 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Intracranial Atherosclerotic Stenosis (ICAS), Stroke
The New Clinical Registration Trial of Interventional Treatment for Patients with Symptomatic Intracranial Artery Stenosis
Background: Intracranial atherosclerotic stenosis (ICAS) is a major etiology of stroke worldwide, especially in East and South Asia, accounting for up to 50% of all ischemic stroke.
- Trial name
- CRTICAS-2 (NCT06740513)
- Testing
- Endovascular Treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Carotid Stenosis
Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis
This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients…
- Trial name
- NCT06947720
- Testing
- stenting
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Atherosclerosis, Atherosclerotic Plaque
Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)
The primary goal of the trial is to investigate whether the lipid lowering strategy using Alirocumab plus statin could cause more changes from baseline in intracranial atherosclerotic plaque and hemodynamic features during 6…
- Conditions
- Intracranial Atherosclerosis, Atherosclerotic Plaque, Stenosis
- Trial name
- EAST-aICAS (NCT06080256)
- Testing
- Alirocumab, Atorvastatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Intracranial Arteriosclerosis, Cognitive Impairment
Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial
This study aims to evaluate whether digital cognitive training and/or PCSK9 inhibitor-enhanced lipid-lowering therapy on top of moderate-intensity statin can improve cognitive function in patients with intracranial…
- Trial name
- NCT07605130
- Testing
- Rosuvastatin, Ezetimibe, Recaticimab
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Atheroscleroses, Cerebral, Intracranial Atherosclerosis
Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry)
To study the clinical outcomes after implantation of balloon-expandable drug-eluting stents in patients with symptomatic intracranial atherosclerotic stenosis in prevention of composite event of any stroke and death within 30…
- Conditions
- Atheroscleroses, Cerebral, Intracranial Atherosclerosis, Ischemia Stroke
- Trial name
- NCT06614972
- Testing
- Balloon-expandable drug-eluting stent
- Volunteers
- 520 people
- Sponsor
- RenJi Hospital