Clinical trials: Intranasal Administration
Bioavailability, Dexmedetomidine
Pharmacokinetics of Different Mode Administration of Intranasal Dexmedetomidine
Intranasal dexmedetomidine has been studied and used in children for premedication before anaesthesia or fro sedation. It can be administered by simple dripping or by Mucosal Atomization Device (MAD®).
- Trial name
- NCT03323593
- Testing
- Dexmedetomidine
- Where
- Hong Kong
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Body Dysmorphic Disorder, Obsessive-compulsive Disorder
Oxytocin Administration in BDD and OCD
The purpose of the current study is to investigate the effect of an acute administration of intranasal oxytocin, relative to placebo, on social cognitive impairments among individuals with body dysmorphic disorder and…
- Trial name
- NCT02671266
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
A Study of Olanzapine After Intranasal and Intramuscular Administration
NRL-4, a nasal spray formulation of the atypical antipsychotic olanzapine is being developed by Neurelis Inc. for use as a rescue medication for acute episodes of agitation in schizophrenia, schizoaffective and bipolar I…
- Trial name
- NCT06600477
- Testing
- olanzapine
- Where
- Jordan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurelis, Inc.
Anosmia
Clinical Assessment of Insulin Fast Dissolving Film in Treatment of Post Infection Anosmia
The study aimed to investigate the efficacy of insulin in a new dosage form ( fast dissolving film) in treatment of anosmia in patients post infested with Covid-19. The study implication based in two methods evaluations 1.
- Trial name
- NCT04657809
- Testing
- Insulin film, Fast dissolving film
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soad Ali
Healthy Volunteers
Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers
This was a Phase 1, double blind, two part study in healthy male and female volunteers. Each subject participated in only one part of the study.
- Trial name
- NCT01363063
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Drug Reaction to Analgesic Nos
Phase I Pharmacokinetic Study of RX0041-2
This Phase I study is to examine the systemic pharmacokinetics of RX0041-002 following acute, topical, intranasal administration to healthy male and female volunteers.
- Trial name
- NCT02667106
- Testing
- RX0041-2
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Project Solutions, Inc.
SARS-CoV-2 (COVID-19) Infection
Safety, Tolerability, and Systemic Exposure of Apo-Si- K170A-C76 in Healthy Volunteers
The goal of this First in Human Phase 1 clinical trial is to to assess the safety, tolerability, and systemic exposure of single, twice daily (BID) doses and repeated BID doses of ascending dosing by intranasal administration of…
- Trial name
- BID (NCT07095049)
- Testing
- Apo-Si-K170A-C76
- Where
- Israel
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Interna Therapeutics Ltd.
Dental Anxiety in Children, Child Behaviour
Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy
The rationale of this trial is to evaluate whether combining intranasal atomized midazolam with nitrous oxide offers better behavior management leading to successful treatment completion in comparison with using nitrous oxide…
- Trial name
- NCT07876024
- Testing
- Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Borderline Personality Disorder
The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy Adults
The study will examine behavioral patterns and underlying neural correlates which distinguish patients with borderline personality disorder (BPD) from healthy subjects as they participate in a two-person trust game and will…
- Trial name
- NCT02225600
- Testing
- 40 IU Intranasal Oxytocin, 24 IU intranasal Oxytocin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Nasogasrtic Tube Insertion
Intranasal Lidocaine Spray Versus Nasogastric Tube Administration in the Emergency Room
The goal of this clinical trial is to evaluate whether 10% intranasal lidocaine spray reduces pain and improves the success rate of nasogastric tube (NGT) insertion compared to placebo in adult emergency department patients.
- Trial name
- Lidocaine (NCT07103915)
- Testing
- Lidocaine 10% Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Binge Eating Disorder
Clinical Trial on Binge Eating Disorder, Treatment With Naloxone Spray
The investigators are studying a new treatment for one subtype of obesity. Obesity is not a disease. It is a symptom of several different diseases.
- Trial name
- BED (NCT01567670)
- Testing
- Naloxone
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Lightlake Sinclair Ltd.
Healthy
A Study of Human Rhinovirus Type 16 (HRV-16) Following Administration in the Nose of Healthy Adult Volunteers
The purpose of this study is to evaluate the safety and clinical characteristics of a quantity of human rhinovirus Type 16 (HRV-16) in healthy volunteers.
- Trial name
- NCT01466738
- Testing
- HRV-16 (100 TCID50), HRV-16 (1000 TCID50)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centocor Ortho Biotech Services, L.L.C.
Drug Overdose
A Usability Assessment of Naloxone by Community Members
This will be a usability trial to assess administration of naloxone via intramuscular, atomized intranasal, and nasal spray routes by nonmedical community members.
- Trial name
- NCT03309449
- Testing
- Syringe and needle, Intranasal mucosal atomization device, Nasal spray
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Healthy Volunteers
Study to Determine the Tolerability, Safety and Pharmacokinetics of Ketorolac Tromethamine by Intranasal Administration in Healthy Volunteers
This was a phase 1, open label, multiple dose study in healthy male and female volunteers. Subjects received intranasal ketorolac tromethamine (30 mg) three times daily (t.i.d.) for three days (seven doses in total).
- Trial name
- NCT01363050
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Narcolepsy
Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition
15 patients with narcolepsy and 15 healthy controls will be included in the study. According to a randomized, double-blind protocol they will receive intranasally at night first Orexine A and approximately two weeks later placebo…
- Trial name
- NARKOREX (NCT00484757)
- Testing
- Orexine A
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Zentrum für Integrative Psychiatrie
Neurologic Diseases, General
Intranasal Administration of Dodecyl Creatine Ester (CBT101) in Healthy Male Subjects
A Phase 1, Randomized, Double-Blinded, Placebo-Controlled study to Evaluate the Safety, Tolerability,and Pharmacokinetics of Single and Multiple Ascending Doses of CBT101 given intranasally in Healthy Male Subjects.
- Trial name
- CBT101 (NCT07050316)
- Testing
- CBT101
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ceres Brain Therapeutics
Influenza
Single Ascending Dose Challenge Study to Determine Safety and Reactogenicity of an Influenza Challenge Virus
This is a non-controlled, open-label, single-center, dose-escalation study to determine the safety, infectivity, and immune responses elicited from of the potential influenza virus challenge strain.
- Trial name
- NCT04106817
- Testing
- Live, wild-type A/California/H1N1 2009 influenza virus
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- WCCT Global
Social Psychology
Neuropeptides and Social Behavior
It has long been established that interpersonal relationships can have a profound impact on health and well-being. Yet, we are still learning about the complex biological processes that contribute to positive social interactions…
- Trial name
- NCT01680718
- Testing
- Intranasal oxytocin, Intranasal vasopressin
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dexamethasone Administration, Intranasal Administration
Evaluation of the Bioavailability of Dexamethasone in Healthy Subjects
The most important property of a dosage of a drug administration is its ability to deliver the active ingredient to the site of action in a quantity sufficient to exert the expected pharmacological effect.
- Conditions
- Dexamethasone Administration, Intranasal Administration, Inflammation, Intravenous Drug Usage
- Trial name
- NCT05647408
- Testing
- Dexamethasone
- Where
- Mexico
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Migraine
Bioavailability Study to Compare OPTINOSE SUMATRIPTAN With IMITREX® in Healthy Subjects
The purpose of this study is: To compare the single-dose pharmacokinetics (PK) of intranasal administration of 20 mg OPTINOSE SUMATRIPTAN with 20 mg IMITREX® (sumatriptan) Nasal Spray, 100 mg IMITREX® (sumatriptan) Oral Tablet…
- Trial name
- NCT01507610
- Testing
- Sumatriptan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Optinose US Inc.