Clinical trials: Intraocular Pressure
Obstructive Sleep Apnoea, Primary Open Angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 1
Lowering of the pressure in the eye (intraocular pressure, IOP) is the only proven treatment for Primary Open-angle Glaucoma (POAG).
- Trial name
- PAIR (NCT03127813)
- Testing
- Application of continuous positive airway pressure (CPAP)
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Intraocular Pressure
Effect of Central Corneal Thickness On IOP Using Various Tonometers
The primary purpose of this study is to evaluate the effects of ocular physical properties on intraocular pressure (IOP) measurements in eyes with healthy corneas using the following instruments to measure IOP: Goldmann…
- Trial name
- CCT (NCT00570791)
- Testing
- Tonometer
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Intracranial Pressure Increase
Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy
This study will test the use of video ophthalmoscope to provide information about intracranial pressure without the use of invasive methods, anesthesia or contact with the eye.
- Trial name
- ICP Waveform (NCT04046523)
- Testing
- Video ophthalmoscope
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy
Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Experimental Increase of Intraocular Pressure in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00914394
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Phenylephrine, Laser Doppler Flowmetry
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Intraocular Pressure
Efficacy of Latanoprostene Bunod in Lowering Intraocular Pressure in Japanese Healthy Male Volunteers
The objective of this study is to evaluate the effect of latanoprostene bunod dosed once daily (QD) in reducing intraocular pressure (IOP) measured over a 24-hour period in healthy subjects.
- Trial name
- KRONUS (NCT01895985)
- Testing
- Latanoprostene bunod
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Glaucoma
ICare Self-tonometry - A Head-to-head Comparison to the Gold Standard Goldmann Tonometer
The purpose of this study is to compare glaucoma patients' own I Care measurements by the standard Goldmann applanation tonometer intraocular pressure (IOP) measurements.
- Trial name
- NCT01733550
- Testing
- Home iCare (study nurse), goldmann applanation tonometry, home iCare (by patient)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
COPD, Healthy Subjects
Sublingual Tonometry to Assess Tissue Perfusion in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Sublingual positioning of a silicon capillary system is applied. After 15 min, while the individual is in resting position with closed mouth and normal tidal breathing through the nose is performed, the silicon capillary system…
- Trial name
- subton (NCT01169506)
- Testing
- sublingual silicon capillary
- Where
- Hungary
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Szeged University
Glaucoma
The Water Drinking Test in Glaucoma Study
To investigate the correlation and agreement between the intraocular pressure peaks detected during the water drinking test and modified diurnal tension curve in glaucomatous eyes and to analyse whether this is associated with…
- Trial name
- WIGS (NCT05283031)
- Testing
- Modified Diurnal Tension Curve
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Intraocular Pressure
Comparative Study of the Topcon Tonometers CT-800 and TRK-2P and the Haag-Streit Goldmann Manual Tonometer and Topcon SP-1P
The study will assess the CT-800 and TRK-2P for conformity to ANSI Z80.10-2014 Ophthalmic Instruments - Tonometers, to the FDA Guidance for Industry and FDA Staff, Tonometer-Premarket Notification [510(k)] Submissions, and to the…
- Trial name
- NCT03439774
- Testing
- Topcon CT-800, Topcon TRK-2P
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Glaucoma
Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices
We are testing the accuracy of Reichert's Tono-Vera tonometer by comparing measurements of IOP with this device and measurements with other commonly-used tonometers, including Goldmann Applanation and iCare.
- Trial name
- NCT05523622
- Testing
- Tono-Vera tonometer, Goldman Applanation Tonometry
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Ocular Surface Disease, Glaucoma
Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure
Evaluation of the safety and efficacy of hydrocortisone eye drops in the treatment of OSD (ocular surface disease) patients with and without glaucoma.
- Trial name
- NCT04536129
- Testing
- Hydrocortisone (CORTIVIS ®)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Molise
Intraocular Pressure
iCare ST500 Clinical Trial
Clinical validation of iCare ST500 tonometer per ANSI Z80.10:2014 standard
- Trial name
- NCT05742009
- Testing
- iCare ST500, GAT, iCare IC200
- Where
- Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Icare Finland Oy
Intraocular Pressure
Clinical Validation of iCare IC1000 Tonometer
Clinical validation of iCare IC1000 tonometer per ANSI Z80.10:2014 standard
- Trial name
- NCT06748092
- Testing
- iCare IC1000, iCare IC200, GAT
- Where
- Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Icare Finland Oy
Intraocular Pressure
Horizontal vs. Vertical Positioning of the iCare Rebound Tonometer and Effects on Intraocular Pressure Readings
The goal of this study is to evaluate the agreement between intraocular pressure (IOP) measurements taken by iCare, held in both vertical and horizontal positions.
- Trial name
- NCT02837536
- Testing
- Horizontal iCare, Vertical iCare
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Corneal Dystrophy, Macular Dystrophy
The Efficacy of Hyperemesis Gravidarum on Macular Thickness, Corneal Thickness and Intraocular Pressure in Pregnancy
Aim Physiological changes in intraocular pressure as well as in the cornea and macula may occur during pregnancy. In the literature, there are limited data on ocular findings in hyperemesis gravidarum.
- Conditions
- Corneal Dystrophy, Macular Dystrophy, Hyperemesis Gravidarum - Severe
- Trial name
- NCT05927740
- Testing
- Optic coherence tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Batman Training and Research Hospital
Glaucoma, Inflammatory Response
Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma
The present study's main objective is to assess if there is a significant difference between either of the treatments frequently used in post-op, namely a topic cortisone-based treatment, an non-steroidal anti-inflammatory drug…
- Trial name
- SLT (NCT01058278)
- Testing
- Selective Laser trabeculoplasty
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Glaucoma, Intraocular Pressure
Accuracy of Handheld and Non-contact Tonometry
Monitoring the intraocular pressure (IOP) is one of the most important tests used in follow-up among glaucoma suspects and confirmed glaucomatous patients.
- Conditions
- Glaucoma, Intraocular Pressure, Glaucoma, Suspect
- Trial name
- NCT05352906
- Testing
- Intraocular pressure
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Benha University
Intraocular Pressure
The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients
This an interventional study looking at two different sequences of pre-operative eye drops, to determine which order is more effective in reducing intraocular pressure with pupil dilation.
- Trial name
- NCT03139708
- Testing
- Alphagan, Phenylephrine, Tropicamide
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Intraocular Pressure
iCare IC1000 Alignment Study
The primary objective of this study is to evaluate the performance of the alignment feature of iCare IC1000 tonometer.
- Trial name
- NCT07022054
- Testing
- iCare IC1000 measurement
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icare Finland Oy
Open Angle Glaucoma
Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma
The purpose of this study is to investigate the effect of trabeculectomy, glaucoma drainage devices, cyclophotocoagulation and ocular hypotensive eye-drops on IOP elevation with postural change from the sitting to supine…
- Trial name
- NCT02868502
- Testing
- Goldmann tonometer, Pneumatonometer, Tonopen XL
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center