Clinical trials: Intraoperative
Intraoperative Hypotension
Hypotension Prediction Index (HPI) in Lung Resections
Perioperative hypotension is a risk factor for perioperative complications. Advances in machine learning and artificial intelligence have produced an algorithm that predicts the occurrence of hypotension episodes by analyzing an…
- Trial name
- NCT06202638
- Testing
- HemoSphere monitor with Acumen Hypotension Prediction Index Software
- Where
- 3 sites in Greece, Poland
- Volunteers
- 77 people
- Sponsor
- John Paul II Hospital, Krakow
Postoperative Troponin Elevation, Intraoperative Perfusion
Impact of Intraoperative Perfusion Variability on Postoperative Troponin Elevation in Geriatric Patients Undergoing Major Oncologic Surgery
This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery.
- Trial name
- NCT07786753
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Laparoscopic Cholecystectomy, Postoperative Pain
Subcostal TAP Block and EEG Dynamics in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure. Despite its minimally invasive nature, surgical stimulation and pneumoperitoneum may cause pain-related physiological and…
- Conditions
- Laparoscopic Cholecystectomy, Postoperative Pain, Intraoperative Nociception
- Trial name
- NCT07818954
- Testing
- Remifentanil, Ultrasound-Guided Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Intraoperative Fluoroscopy
Total Hip Arthroplasty: Fluoroscopy vs Freehand
The aim of the study is to compare total hip arthroplasty intervention executed with or without the use of intraoperative fluoroscopy in terms of positioning of the hip prosthesis.
- Trial name
- NCT05653687
- Testing
- Intraoperative fluoroscopy
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Intraoperative Neurophysiological Monitoring
MINDZ-- Minimally Invasive Approach Pilot Study
This clinical investigation is a pilot, first-in-human (FIH) study designed to demonstrate proof of concept, safety, and functional performance of the MINDZ subdural electrode grid when used in relevant neurosurgical settings.
- Trial name
- MINDZ-MAP (NCT07543406)
- Testing
- MINDZ Subdural Electrode Grid
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- Neurosoft Bioelectronics SA
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal
Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair
The purpose of this study is to compare two intravenous anesthetics, remimazolam and propofol, for their effects on intraoperative hemodynamic stability in patients undergoing thoracic or abdominal endovascular aortic repair.
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal, Intraoperative Hypotension, Hemodynamic Instability During Anesthesia
- Trial name
- NCT07806006
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Intraoperative Hypotension
A Comparative Study Protocol Investigating the Association Between Intraoperative Hypotension and the Use of Ring- Versus Propofol-Based Anesthesia in Elderly Patients Undergoing Non-Cardiac Surgery
we conducted this multicentre retrospective cohort study to evaluate the association between the choice of induction agent (ciprofol versus propofol) and the incidence of IOH in geriatric patients having non-cardiac surgery.
- Trial name
- NCT07808125
- Where
- China
- Volunteers
- 85,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Intraoperative Complications, Intraoperative Bleeding
Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE
In spine surgery, it is important to try to minimize bleeding. In particular, spine surgery often involves inserting hardware into bone, and/or removing bone in the spine.
- Conditions
- Intraoperative Complications, Intraoperative Bleeding, Intraoperative Blood Loss, Hemostasis
- Trial name
- Ostene VIBe (NCT06450834)
- Testing
- Ostene
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- University of Maryland, Baltimore
Appendicitis, Acute, Appendectomy
Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy
Acute appendicitis is the most common surgical emergency in children, and laparoscopic appendectomy is its standard treatment. Although intraoperative adverse events (iAEs) are recognized as an important determinant of surgical…
- Conditions
- Appendicitis, Acute, Appendectomy, Intraoperative Complications, Patient Safety
- Trial name
- PedAppy-iAE (NCT07794618)
- Testing
- Laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ahmet Burak Doğan, MD
Spine Surgery, Intraoperative Hypotension
Superiority of Phenylephrine Versus Norepinephrine in Complex Spine Surgery (SPiNeS)
The purpose of this research is to compare two commonly used medications, phenylephrine and norepinephrine, that are used to treat low blood pressure during complex spine surgery.
- Conditions
- Spine Surgery, Intraoperative Hypotension, Tissue Perfusion
- Trial name
- NCT07796282
- Testing
- Phenylephrine hydrochloride infusion, Norepinephrine bitartrate infusion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Intraoperative Ventilation, Respiratory Mechanics
Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery
This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery.
- Trial name
- NCT07543939
- Testing
- PRVC Ventilation
- Where
- Saudi Arabia
- Volunteers
- 52 people
- Sponsor
- Specialized Medical Center (SMC)
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Intraoperative Neurophysiological Monitoring, Malignant Brain Tumors
Intraoperative Neurophysiological Monitoring in Brain Tumor Surgery: Prospective Cohort Studies
BACKGROUND Brain tumor surgery requires balancing two competing priorities: maximizing the extent of tumor resection to improve survival while preserving neurological function.
- Conditions
- Intraoperative Neurophysiological Monitoring, Malignant Brain Tumors, Motor Evoked Potential Monitoring, Cortico-cortical Evoked Potential Monitoring
- Trial name
- NCT07789938
- Testing
- Intraoperative neurophysiological monitoring, no Intraoperative neurophysiological monitoring
- Where
- Denmark
- Volunteers
- 166 people
- Sponsor
- Odense University Hospital
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Intraoperative Bradycardia
Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements
The RAPID trial is a randomized, single-center trial investigating whether giving atropine at heart rates below 60 beats per minute versus giving atropine only at heart rates below 30 beats per minute reduces the amount of…
- Trial name
- RAPID (NCT06922097)
- Testing
- Giving atropine at heart rates below 60 beats per minute, Giving atropine at heart rates below 30 beats per minute
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- University of Hamburg-Eppendorf
Intraoperative Hypotension
Continuous Finger-cuff Arterial Pressure Monitoring and Intraoperative Hypotension During Non-cardiac Surgery: the Randomized DETECT II Trial
This is a randomized trial (1) investigating whether continuous finger-cuff - compared to intermittent oscillometric - arterial pressure monitoring reduces the amount of intraoperative hypotension (specifically, from the start of…
- Trial name
- DETECT II (NCT06753097)
- Testing
- Continuous finger-cuff arterial pressure monitoring
- Where
- Germany
- Volunteers
- 930 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital