Clinical trials: Intraoperative Ventilation
Mechanical Ventilation
The Effect of Intraoperative Ventilation Mode on Hemodynamics and Lung Dynamics
In this study, it was aimed to compare the effects of pressure-controlled volume-guaranteed ventilation (PCV-VG) and volume-controlled ventilation (VCV) on lung dynamics and hemodynamics in patients undergoing vertebral surgery…
- Trial name
- NCT05776589
- Testing
- The mechanical ventilation mode
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Izmir Ataturk Training and Research Hospital
Emergency Abdominal Surgery, Mechanical Ventilation
Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery
The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at…
- Conditions
- Emergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity
- Trial name
- IMPROVE-2 (NCT03987789)
- Testing
- Driving-pressure-guided group, Low PEEP
- Where
- 28 sites in France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Surgery
Influence of the End-inspiratory Pause on Mechanical Ventilation.
This study evaluates the influence of two different end-inspiratory pause (EIP) times on respiratory mechanics and arterial gases of surgical patients when ventilated under an open lung approach (OLA) strategy.
- Trial name
- NCT03568786
- Testing
- End-inspiratory pause 10%, End-inspiratory pause 30%
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Surgery--Complications
Intraoperative Protective Ventilation for Obese Patients Undergoing Gynaecological Laparoscopic Surgery
Background. The use of a comprehensive strategy providing low tidal volumes, peep and recruiting maneuvers in patients undergoing open abdominal surgery improves postoperative respiratory function and clinical outcome.
- Trial name
- Inprove4large (NCT03157479)
- Testing
- Intravenous anesthetic, Crystalloid Solutions, Esophageal pressure measurement
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
One Lung Ventillation (OLV), Erector Spina Plan Block
Effect of Erector Spinae Plane Block on Cerebral Oxygenation During One-Lung Ventilation
The aim of this study is to evaluate the effect of the erector spinae plane block, used to reduce postoperative pain, on cerebral oxygenation in thoracic surgery patients undergoing one-lung ventilation in the lateral decubitus…
- Conditions
- One Lung Ventillation (OLV), Erector Spina Plan Block, Near Infrared Spectroscopy, Cerebral Desaturation
- Trial name
- NCT07432230
- Testing
- Erector Spinae Plane Block, A preoperative erector spinae plane block will not be administered
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Kayseri City Hospital
Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness
Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy
Abstract Objective: The aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed…
- Conditions
- Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness, Airway Complications, Respiratory Complications
- Trial name
- NCT07678086
- Testing
- Pressure Transducer, Traditional Palpation Method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Pulmonary Complications
Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive…
- Trial name
- VACARM (NCT04408495)
- Testing
- Intervention group_MRA, Control group
- Where
- 10 sites in France
- Volunteers
- 441 people
- Sponsor
- Rennes University Hospital
Obesity, Postoperative Pulmonary Complications
Comparison of Standard Versus Dynamic Compliance-Guided Individualized PEEP in Obese Patients Undergoing Spinal Surgery
This study aims to compare standard positive end-expiratory pressure (PEEP) with dynamic compliance-guided individualized PEEP in obese patients undergoing elective spinal surgery under general anesthesia.
- Conditions
- Obesity, Postoperative Pulmonary Complications, Mechanical Ventilation
- Trial name
- NCT07388719
- Testing
- Standard PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital
Intraoperative Oxygenation and Pulmonary Mechanics
Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation.
- Trial name
- NCT07325773
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Marmara University
Head and Neck Cancer, Obstructive Sleep Apnea
Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve
Published data suggest that the glossopharyngeal nerve innervates pharyngeal musculature important for maintenance of upper airway patency.
- Trial name
- NCT05754216
- Testing
- Nerve stimulation using nerve stimulation device and sterile wire electrode.
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
ASA Class I/II Patients, General Anesthetic
PCV vs VCV in Low-Flow Anesthesia
The aim of this observational study is to investigate the effects of ventilation modes on intraoperative and postoperative lung functions in patients under general anesthesia.
- Conditions
- ASA Class I/II Patients, General Anesthetic, Low Flow Anesthesia
- Trial name
- NCT07305129
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- HULYA TOPCU, MD
Lung Cancer
Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation
This is a randomized placebo-controlled trial studying the effects of intraoperative continuous airway pressure (CPAP) on the inflammatory response of the lung with cancer undergoing lobectomy.
- Trial name
- NCT01368601
- Testing
- CPAP (Continuous airway pressure)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Parc de Salut Mar
Intraoperative Mechanical Ventilation
Low Tidal Volume for Lung Protection During Anesthesia of Laparoscopic Surgery in Trendlenburg Position
Mechanical ventilation of patients undergoing laparoscopic surgery may induce lung injury. Since lung protective ventilation has been recommended during anesthesia to prevent ongoing lung injury, so in our study the investigators…
- Trial name
- lapVent (NCT02553057)
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- AlRefaey Kandeel
Infant, Newborn, Diseases, Pain
Study of Morphine in Postoperative Infants to Allow Normal Ventilation
OBJECTIVES: I. Compare nonmechanically ventilated infants who receive morphine postoperatively as intermittent intravenous bolus doses or as a continuous intravenous infusion targeted to reach a steady-state concentration. II.
- Trial name
- NCT00004696
- Testing
- morphine
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Respiratory Mechanics, Intraoperative
Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery
Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation.
- Trial name
- NCT07304479
- Testing
- Sevoflurane (Volatile Anesthetic), Desflurane (volatile anesthetic)
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- National and Kapodistrian University of Athens
Ventilator-induced Lung Injury
Intraoperative Lung-Protective Ventilation in Neurosurgery
The purpose of this study is to explore the effectiveness of lung-protective ventilation during general anesthesia for neurosurgical procedures on postoperative pulmonary outcome, compared with traditional ventilation.
- Trial name
- NCT02386683
- Testing
- lung-protective ventilation
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Capital Medical University
Colorectal Surgery, Postoperative Pulmonary Complications (PPCs)
Dorsal Vetilation and PPCs in Colorectal Cancer Surgery Patients
Postoperative pulmonary complications (PPCs) are common in patients after major abdominal surgery. It has been shown that 5-40% of patients occur PPCs after major surgery, and the mid to high PPC rate is observed after…
- Trial name
- NCT06662799
- Where
- China
- Volunteers
- 92 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Respiratory Disorders, Intensive Care, Neonatal
Timing of Planned Caesarean Section and Morbidity of the Newborn
The caesarean section rate is rising globally. About 10% of the newborns are submitted to a neonatal department after planned caesarean section, primarily with respiratory disorders.
- Trial name
- NCT00835003
- Testing
- Elective caesarean section
- Where
- 7 sites in Denmark
- Volunteers
- 1,273 people
- Sponsor
- Aarhus University Hospital
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University