Clinical trials: Intravenous
Acute Stroke
A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients
This study was jointly developed and is jointly led by investigators at Massachusetts General Hospital and the intramural division of NINDS.
- Trial name
- MR WITNESS (NCT01282242)
- Testing
- IV rt-PA
- Where
- 14 sites in United States
- Volunteers
- 88 people
- Sponsor
- Lee Schwamm
Infections, Bacterial
To Evaluate Plasma and Pulmonary Pharmacokinetics of GSK2140944
Antimicrobial penetration can be assessed through evaluation of antimicrobial concentrations in various lung compartments, including bronchial mucosal tissue, epithelial lining fluid (ELF), and alveolar macrophages (AM).
- Trial name
- NCT01934205
- Testing
- GSK2140944 (Single dose), GSK2140944 (Multiple dose)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers, Rheumatoid Arthritis
A Study of Intravenous CPTX2309 in Healthy Participants and Participants With Moderate to Severe Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE)
The purpose of this study is to assess the safety and tolerability of CPTX2309 in healthy adult participants and adult participants with moderate to severe rheumatoid arthritis or systemic lupus erythematosus.
- Conditions
- Healthy Volunteers, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT06917742
- Testing
- CPTX2309
- Where
- 3 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Capstan Therapeutics
Bariatric Surgery, Lidocaine
Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy
Although laparoscopic (LAP) bariatric surgery is minimally invasive. Following any laparoscopic procedure, patients typically experience the peak of postoperative pain within the first 24 hours.
- Conditions
- Bariatric Surgery, Lidocaine, Dexmedetomidine
- Trial name
- NCT07327905
- Testing
- intravenous lidocaine, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Postoperative; Dysfunction Following Cardiac Surgery
Cerebral Energy State in Cardiac Surgery
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by…
- Trial name
- NCT02846818
- Testing
- Microdialysis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Intravenous, Thrombosis
Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
Acute ischemic stroke is one of the devastating diseases that increase hospitalization, disabilities, and deaths worldwide. Current treatment with intravenous thrombolytic agent can help reduce disabilities and improve quality of…
- Conditions
- Intravenous, Thrombosis, Acute Ischemic Stroke
- Trial name
- NCT06498323
- Testing
- tenecteplase
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Brain Diseases, Spinal Cord Diseases
Dose Finding Study of Gadavist in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
The purpose of this study is to look at the safety (what are the side effects) and efficacy (how well does it work) of Gadavist when used for taking images of the brain and spine.
- Trial name
- NCT00862459
- Testing
- Gadobutrol~0.03 mmol/kg BW (Gadavist, Gadovist, BAY86-4875), Gadobutrol~0.1 mmol/kg BW (Gadavist, Gadovist, BAY86-4875), Gadobutrol~0.3 mmol/kg BW (Gadavist, Gadovist, BAY86-4875)
- Where
- 27 sites in United States, Argentina and 2 more
- Volunteers
- 237 people
- Sponsor
- Bayer
Pian, Fear
The Effects of Using an Interactive Game With Virtual Reality for Children During Intravenous Placement
To develop the intervention strategies of hospitalized school-age children with IV placement, using interactive virtual reality(VR)as a guiding play and emotional catharsis play, to further examine the effectiveness of reducing…
- Trial name
- NCT04558086
- Testing
- Virtual reality, Photo book
- Where
- Taiwan
- Volunteers
- 134 people
- Sponsor
- National Yang Ming Chiao Tung University
Uremic Pruritus
CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
This is a multicenter, international study to evaluate the safety and efficacy of intravenous (IV) CR845 at a dose of 0.5 mcg/kg administered after each dialysis session.
- Trial name
- KALM-2 (NCT03636269)
- Testing
- CR845 0.5 mcg/kg
- Where
- 92 sites in United States, Australia and 9 more
- Volunteers
- 473 people
- Sponsor
- Cara Therapeutics, Inc.
Type 2 Diabetes Mellitus, Iron Deficiency
Ferric Carboxymaltose in Type 2 Diabetes Mellitus (T2DM) Patients With Iron Deficiency
The purpose of this study is to investigate the correlation between HbA1c and iron status in Type 2 Diabetes mellitus patients with iron deficiency by intravenous substitution of iron.
- Trial name
- CLEVER (NCT01513369)
- Testing
- ferric carboxymaltose, NaCl (0,9%)
- Where
- 6 sites in Germany
- Volunteers
- 152 people
- Sponsor
- GWT-TUD GmbH
Laryngoscopic Stress Response, Dexmedetomidine
Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial
After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication.
- Conditions
- Laryngoscopic Stress Response, Dexmedetomidine, Lignocaine
- Trial name
- NCT07611890
- Testing
- IV dexmedetomidine, IV Lignocaine
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Rawalpindi Institute of Cardiology
Neoplasms
Safety and Efficacy of Intravenous IDOV-SAFETM in Patients With Advanced Solid Tumors
This is an open-label, dose escalation, phase I study to evaluate safety tolerability, MTD or MFD, pharmacokinetic profile, immunogenicity, and pharmacodynamic profile of IDOV-SAFETM in patients with advanced solid tumors.
- Trial name
- NCT06346041
- Testing
- Oncolytic Virus injection(IDOV-SAFETM)
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Healthy Subjects
A Trial to Evaluate the Absolute Bioavailability of Cenerimod in Healthy Male Participants
The goal of this clinical trial is to learn about the absolute bioavailability of cenerimod in healthy participants. It will also provide information about the safety of cenerimod.
- Trial name
- NCT07301723
- Testing
- Cenerimod (oral), 14C-Cenerimod (i.v.)
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Thrombosis
A Short and Long Intravenous Infusion Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BMS-962212 in Healthy Subjects
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics following increasing doses of 2 h (Part A) and 5 day (Part B) continuous IV infusions of BMS-962212 in healthy subjects…
- Trial name
- NCT03197779
- Testing
- BMS-962212, Aspirin
- Where
- 3 sites in United States
- Volunteers
- 691 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Postoperative Pain
Effect of Infusion of Lidocaine, Magnesium and Remifentanil Perioperatively in Patients Undergoing Mastectomy
This study aims to compare the quality of perioperative analgesia of lidocaine, magnesium sulphate and remifentanil in patients undergoing mastectomy
- Trial name
- NCT02309879
- Testing
- Remifentanil infusion, Lidocaine infusion, Magnesium sulphate infusion
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Hospital de Base
Rheumatoid Arthritis
The Study of Abatacept in Combination With Etanercept
The Study was designed to look at the safety and efficacy of abatacept in combination with etanercept.
- Trial name
- NCT00162279
- Testing
- Abatacept
- Where
- 35 sites in United States
- Volunteers
- 141 people
- Sponsor
- Bristol-Myers Squibb
Coronavirus Disease 2019 (COVID-19)
Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.
A randomized, open-label, multicenter, three-arm clinical trial to study the efficacy and safety of passive immunotherapy (convalescent plasma and anti-COVID-19 human immunoglobulin) compared to the standard treatment in Colombia.
- Trial name
- NCT04395170
- Testing
- COVID-19 convalescent plasma, Anti-COVID-19 human immunoglobulin, Standard (specific) therapy for COVID-19
- Where
- Colombia
- Volunteers
- 75 people
- Sponsor
- Lifefactors Zona Franca, SAS
Healthy
Study of Subcutaneous and Intravenous ALXN1720 With and Without rHuPH20 in Healthy Subjects
This study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of ALXN1720 administered subcutaneously (SC) or intravenously (IV).
- Trial name
- NCT04920370
- Testing
- ALXN1720 SC, ALXN1720 IV, rHuPH20
- Where
- United Kingdom
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Iron Deficiency Anemia (IDA)
A Study to Test the Non-Inferiority of Ferric Bepectate IV Against Ferric Carboxymaltose in Patients With Iron Deficiency Anemia
The goal of this clinical trial is to see if a new intravenous iron formulation (Ferric Bepectate IV Injection) can treat adult patients with iron deficiency anemia (IDA) by increasing blood hemoglobin (Hb) as an established…
- Trial name
- NCT07687784
- Testing
- Ferric Bepectate IV Injection, Ferric Carboxymaltose Injection [Ferinject], Ferric Carboxymaltose Injection [Injectafer®]
- Where
- 13 sites in United States, Bulgaria and 2 more
- Volunteers
- 1,366 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Infection, Hand Injury Wrist
Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose…
- Conditions
- Infection, Hand Injury Wrist, Hand Injuries, Hand Injuries and Disorders
- Trial name
- NCT04673877
- Testing
- Systemic IV Vancomycin, Bier Block, Vancomycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.