Clinical trials: Intrusive Memories
Posttraumatic Stress Disorder
The Role of Expectations in the Development of Intrusive Memories
In the experimental study, the well-established trauma film paradigm will be used to investigate the impact of expectations on the development of intrusive memories as a hallmark symptom of PTSD.
- Trial name
- NCT03950869
- Testing
- Positive Expectation Manipulation, Negative Expectation Manipulation
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Intrusive Memories, PTSD
The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and certain polygenic risk scores affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03875391
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusion Symptom
Remote Delivery of a Visuospatial Intervention to Reduce Traumatic Intrusive Memories After Paediatric Intensive Care
This study aims to examine the feasibility and acceptability of a brief intervention, involving a imagery-competing task, remotely delivered to parents who are currently experiencing persistent intrusive traumatic memories at…
- Trial name
- NCT05500105
- Testing
- Simple cognitive task intervention
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Intrusive Memories
Influence of the Noradrenergic System on the Formation of Intrusive Memories
Intrusive memories of traumatic events are core features of posttraumatic stress disorder (PTSD) but little is known about the neurobiological formation of intrusions.
- Trial name
- NCT02541071
- Testing
- Stress Film, Yohimbine, Clonidine
- Where
- Germany
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories of Traumatic Event(s)
Lóa Project: An Exploratory Pilot Randomised Controlled Trial of a Remotely-delivered Brief Cognitive Intervention to Reduce Intrusive Memories of Trauma for Women in Iceland
Intrusive memories are sensory memories of a traumatic event(s) that spring to mind involuntarily, evoke strong emotions, and disrupt functioning in daily life.
- Trial name
- NCT05089058
- Testing
- Brief, digitally delivered imagery-competing task intervention package, comprised of:, Brief, digitally delivered relaxation task intervention, comprised of:
- Where
- Iceland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Intrusive Memories
Behavioral Modulation of Intrusive Memories
The purpose of the study is to examine whether sleep affects the development of intrusive memories.
- Trial name
- NCT03227081
- Testing
- Sleep Deprivation
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories of Traumatic Event(s)
The Lóa Study: A Brief Digital Intervention for Women With Intrusive Memories in the SAGA Cohort
Intrusive memories are sensory memories of a traumatic event(s) that spring to mind involuntarily, and can evoke strong emotions and disrupt functioning in daily life.
- Trial name
- NCT05849337
- Testing
- Brief imagery-competing task, Brief psychoeducation and signposting task, Treatment as usual (TAU)
- Where
- Iceland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Post-traumatic Stress Disorders
Tetris to Reduce Intrusive Memories in Parents After PICU
The purpose of this study is to examine the acceptability and feasibility of a brief behavioural intervention involving Tetris gameplay to prevent intrusive traumatic memories in parents after paediatric intensive care.
- Trial name
- NCT04186962
- Testing
- Behavioral: Simple cognitive task
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- King's College London
PTSD, Intrusive Memories
Estradiol and Intrusive Memories
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma.
- Conditions
- PTSD, Intrusive Memories, Intrusion Symptom, Trauma
- Trial name
- EstraMemo (NCT07419594)
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Post-traumatic Stress Disorder, Cocaine Use Disorder
Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
An investigation of the effect of matrix-metalloproteinase-(MMP)-9 inhibition with minocycline on the reconsolidation of trauma- or cocaine-related memories
- Trial name
- Memocycline (NCT05902819)
- Testing
- Imagery, Minocycline
- Where
- Switzerland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Intrusive Memories
The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories
The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog…
- Trial name
- NCT04871269
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories
The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03031405
- Testing
- Oxytocin nasal spray
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories
Cortisol and the Formation of Intrusive Memories
Intrusive memories of traumatic events are core features of posttraumatic stress disorder (PTSD) but little is known about the neurobiological formation of intrusions.
- Trial name
- NCT02552654
- Testing
- Stress Film, Hydrocortisone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories of Traumatic Event(s)
A Brief GAmeplay Intervention for NHS ICU Staff Affected by COVID-19 Trauma (GAINS Study)
Intensive care unit (ICU) staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS (NCT04992390)
- Testing
- Brief digital imagery-competing task intervention
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
Non-clinical Participants, Intrusive Memories
Understanding Reactions to Emotional Material in the Media During COVID-19 - Study 2
This second feasibility study aims to adapt a protocol usually run in the laboratory in the Psychology Department for healthy participants (including the trauma film paradigm (James et al., 2016) and a simple cognitive task…
- Trial name
- NCT05063825
- Testing
- Simple cognitive task intervention
- Where
- Sweden
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Healthy Participants, Intrusive Memories
Understanding Reactions to Emotional Material in the Media During COVID-19
This feasibility study aims to adapt a protocol usually run in the laboratory in the Psychology Department for healthy participants (including the trauma film paradigm (James et al., 2016) and a simple cognitive task…
- Trial name
- NCT04608097
- Testing
- Simple cognitive task intervention
- Where
- Sweden
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Mild Cognitive Impairment, Mild Dementia
Assessing Cognitive Decline at Home
Neuropsychiatric symptoms (NPS) refer to a range of mental and emotional issues that can be observed through how patients move, perform daily tasks, and express feelings on their faces.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Dementia Alzheimers, Dementia
- Trial name
- NCT06704971
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University
Intrusive Memories of Traumatic Event(s)
A Brief Cognitive Task Intervention for NHS Staff Affected by COVID-19 Trauma (GAINS-2 Study)
Frontline healthcare staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS-2 (NCT05616676)
- Testing
- Brief digital imagery-competing task, Brief digital music-listening task, Treatment As Usual
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
Memory
Intrusive Reexperiencing: The Role of Working Memory Capacity and Thought Suppression
This study aims at identifying risk factors for the development of intrusive reexperiencing symptoms. In particular, the investigators examine the influence of working memory capacity and thought suppression on the occurrence of…
- Trial name
- NCT01007682
- Testing
- Show distressing movie and tell half of the two study groups to suppress memories of the movie
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland