Clinical trials: Invasive Ventilation
Hypercapnic Respiratory Failure
Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure
The purpose of the study is to determine the optimal method to withdraw non-invasive ventilation after an episode of hypercapnic respiratory failure.
- Trial name
- NCT00775710
- Testing
- Nocturnal non-invasive ventilation
- Where
- 3 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Clinic of Barcelona
Pulmonary Disease, Chronic Obstructive, Airflow Obstruction, Chronic
Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
When using the Breathe Technologies Ventilation System during simulated activities of daily living (ADLs), Subjects with moderate-to-severe chronic obstructive pulmonary Disease (COPD) will be comfortable and report acceptability.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airflow Obstruction, Chronic, Chronic Obstructive Airway Disease, Chronic Obstructive Lung Disease
- Trial name
- PRIDE (NCT01355978)
- Testing
- Noninvasive Open Ventilation System
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Breathe Technologies, Inc.
Pituitary Adenoma Invasive, Nasal Obstruction
Nasal Obstruction Compared by Rhinomanometry and Nasal Inspiratory Peak Flow After Endoscopic Nasal Surgery
The aim of the project is to determine whether nasal inspiratory peak flow is sufficient for preoperative and postoperative measurement of nasal patency compared to rhinomanometry.
- Trial name
- NCT05921396
- Testing
- Nasal patency - rhinomanometry, Nasal patency - nasal inspiratory peak flow
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Amyotrophic Lateral Sclerosis
Study of Pioglitazone in Patients With Amyotrophic Lateral Sclerosis
Primary objective: Efficacy of pioglitazone (45 mg/day) as add-on therapy to standard therapy with riluzole in patients with ALS compared to placebo in terms of survival (mortality defined exclusively as death).
- Trial name
- NCT00690118
- Testing
- pioglitazone
- Where
- 15 sites in Germany
- Volunteers
- 219 people
- Sponsor
- University of Ulm
Chronic Respiratory Disease
Development and Validation of the BVQ
The main aim of this study is the development of the Beliefs about Ventilation Questionnaire (BVQ).
- Trial name
- NCT02894190
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Pneumonia-associated Acute Hypoxemic Respiratory Failure
Non-invasive Ventilation Versus High Flow Oxygen
The purpose of the study is to compare the efficacy of alternating Non Invasive Ventilation NIV and High Flow Oxygen HFO compared to High Flow Oxygen HFO alone on gas exchanges and prognosis in pneumonia-associated acute…
- Trial name
- HFO (NCT03758508)
- Testing
- High Flow Oxygen nasal cannula, Noninvasive ventilation
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Niguarda Hospital
Respiratory Insufficiency
B-type Natriuretic Peptide for the Management of Weaning
Several clinical findings and clinical trials have suggested that the prognosis of intensive care unit (ICU) patients may be improved by minimizing the positive fluid balance.
- Trial name
- BMW (NCT00473148)
- Testing
- BNP-guided weaning, Standard physician-directed weaning
- Where
- France
- Volunteers
- 265 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive
Respiratory Drive Response in COPD Patients During Exercise With Non Invasive Ventilation (NIV).
A constant load exercise during 10 minutes will be performed in a group of Chronic Obstructive Pulmonary Disease patients, in a basal condition (spontaneous breathing); under noninvasive mask ventilation and with high flow nasal…
- Trial name
- HFNIV (NCT04597606)
- Testing
- Exercise with spontaneous ventilation., Exercise with NIV, Exercise with HFNC
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Javier Sayas Catalan
Coronavirus
Plasma Exchange in Patients With COVID-19 Disease and Invasive Mechanical Ventilation: a Randomized Controlled Trial
Plasma exchanges with 5% human albumin (2/3 of the exchanged plasma volume) and fresh frozen plasma (FFP: 1/3) in patients with quick <50% or only with 5% albumin in patients with quick of 50% or more.
- Trial name
- REP-COVID (NCT04374539)
- Testing
- Plasma exchange, Standar medical treatmen
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium
Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU
Background: ICU hospitalization is associated with loss of strength, functionality and delirium. The "Start to Move protocol" demonstrated efficacy in improving and minimizing such effects.
- Conditions
- Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium, Intensive Care Neuropathy, Intensive Care Unit Syndrome
- Trial name
- STM (NCT05053724)
- Testing
- Star to move Protocol
- Where
- Chile
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hospital Felix Bulnes
Perfusion; Complications, Mechanical Ventilation Complication
A Non-invasive Evaluation of Kidney-Lung Interactions
The present study aims to evaluate, with non-invasive methods, the relationships existing between PEEP and renal perfusion in patients undergoing surgery and requiring ventilatory support and monitoring in intensive care.
- Trial name
- KIDNEY-LUNG (NCT03747731)
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- St. Bortolo Hospital
Acute Respiratory Failure
Non-Invasive Mechanical Ventilation in Elderly Patients
The efficacy of NIMV to treat HARF has been widely demonstrated. However, in most of the studies performed in ICUs and in another facilities the mean age of the patients is usually less than 70 years.
- Trial name
- NCT00600639
- Testing
- Non-invasive mechanical ventilation using a BiPAP Vision or any other ICU ventilators with NIV option, standard medical therapy plus oxygen that includes salbutamol, prednisolone and antibiotics as needed, standard medical therapy that includes salbutamol, prednisolone and antibiotics as needed
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Respiration, Artificial, Noninvasive Ventilation
Epidemiology of Non- Invasive Mechanical Ventilation in Argentina: a Multicenter Observational Study
Introduction Non-invasive mechanical ventilation (NIMV) is a fundamental strategy in the management of acute respiratory failure, preventing intubation and reducing complications.
- Conditions
- Respiration, Artificial, Noninvasive Ventilation, Intensive Care Units
- Trial name
- EpVAr-VMNI (NCT06837402)
- Where
- Argentina
- Volunteers
- 246 people
- Sponsor
- Argentinian Intensive Care Society
Respiratory Failure, Obesity
Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients…
- Trial name
- NCT05530434
- Testing
- transpulmonary pressure guided positive end expiratory pressure, standard positive end expiratory pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Mississippi Medical Center
SARS-CoV 2
Association Between BMI and COVID-19
This study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. Collating data from a large volume of patients with COVID-19 admitted in ICU across multiple…
- Trial name
- BMI-SARS-CoV-2 (NCT04391738)
- Testing
- Patients admitted to Intensive Care Unit with SARS-CoV2
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Lille
Respiratory Insufficiency, Pneumonia, Aspiration
Feeding Children Nasogastrically Versus Nasojejunally While Receiving Noninvasive Positive Pressure Ventilation
The investigators are studying whether it is safe and effective to provide enteral nutrition to critically ill children via the nasogastric route, as opposed to the nasojejunal route, while they are receiving noninvasive positive…
- Conditions
- Respiratory Insufficiency, Pneumonia, Aspiration, Nutrition Disorders
- Trial name
- FeedNIV (NCT01301352)
- Testing
- Route of feeding (nasogastric vs. nasojejunal)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
COVID-19 Pneumonia, Non-invasive Ventilation
The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia
High frequency oscillatory ventilation (HFOV), as an ideal lung protection ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05706467
- Testing
- Non-invasive high-frequency oscillatory ventilation, Non-invasive continuous positive airway pressure ventilation
- Volunteers
- 20 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Infant, Premature
Automated Oxygen Control in Preterms on Non-invasive Ventilation
This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of…
- Conditions
- Infant, Premature, Airway Morbidity
- Trial name
- NCT07622563
- Testing
- Closed loop automated oxygen control
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Obstructive Pulmonary Disease, Hypercapnia
Non-invasive Home Ventilation in Patients With Severe Hypercapnic Chronic Obstructive Pulmonary Disease
In COPD patients with chronic hypercapnic respiratory failure, the prognosis is poor and the treatment with non invasive ventilation is actually well established. However the best mode of ventilation is not well known.
- Trial name
- SOMNOVENT' (NCT03934749)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon