Clinical trials: Iris
Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis
Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis ,
This was a multi-center, randomized, active-controlled, open-label study. Approximately 24 patients with active, non-infectious intermediate-, posterior-, or panuveitis requiring systemic immunosuppressive therapy were enrolled.
- Conditions
- Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Non-infectious Panuveitis
- Trial name
- NCT01526889
- Testing
- LFG316, Conventional Therapy
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
Congenital Aniridia
Congenital Aniridia Patient Questionnaire
Congenital aniridia is a pan-ocular genetic disease characterized by a partial or complete absence of the iris, hence its name. The prevalence ranges from 1 / 40,000 to 1 / 96,000 births, but it may be underestimated.
- Trial name
- Aniridia-Quizz (NCT05390801)
- Testing
- Survey
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cataract, Diabetes
Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties
Modern phacoemulsification techniques have made cataract surgery safe and efficient over the past several decades. Although the phacoemulsification procedure has improved greatly, cataract surgery still involves trauma.
- Conditions
- Cataract, Diabetes, Pseudoexfoliation Syndrome
- Trial name
- POL (NCT01767012)
- Testing
- Polylens EC-HY10-PAL (coated), Polylens EC-Y10-PAL (uncoated)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Pseudoexfoliation Glaucoma, Primary Open-angle Glaucoma
Micropulse Laser Trabeculoplasty as Adjunctive Treatment in Patients With Pseudoexfoliation Glaucoma
This study aims to evaluate the effect of a single session of micropulse laser trabeculoplasty (MLT) on cornea in eyes with primary open glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG).
- Trial name
- NCT03483402
- Testing
- Micropulse laser trabeculoplasty
- Volunteers
- 27 people
- Sponsor
- University Hospital of Patras
Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes
Real World Evidence of Xen45 Gel Implant in Pseudoexfoliation Glaucoma
The Xen implant is an ab interno device that has been shown to be effective in reducing intraocular pressure in several types of glaucoma, although the evidence in pseudoexfoliative glaucoma is limited.
- Conditions
- Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes, Open Angle Glaucoma
- Trial name
- NCT06993311
- Testing
- Xen Gel Stent implantation
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Xerencia de Xestión Integrada de Ferrol
Ciliary Body and Choroid Melanoma, Medium/Large Size, Extraocular Extension Melanoma
Vaccine Therapy With or Without Sargramostim in Treating Patients Who Have Undergone Surgery for Melanoma
This randomized phase II trial is studying vaccine therapy and sargramostim to see how well they work compared to vaccine therapy alone in treating patients who have undergone surgery for stage IIB, stage IIC, stage III, or stage…
- Conditions
- Ciliary Body and Choroid Melanoma, Medium/Large Size, Extraocular Extension Melanoma, Iris Melanoma, Stage IIB Melanoma
- Trial name
- NCT00089063
- Testing
- tyrosinase peptide, gp100 antigen, MART-1 antigen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Pseudoexfoliation Syndrome
The Endothelial Count in Pxf
Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.
- Trial name
- NCT03265457
- Testing
- Specular microscopy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ciliary Body and Choroid Melanoma, Medium/Large Size, Extraocular Extension Melanoma
VEGF Trap in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
This phase II trial is studying how well VEGF Trap works in treating patients with recurrent stage III or stage IV melanoma that cannot be removed by surgery.
- Conditions
- Ciliary Body and Choroid Melanoma, Medium/Large Size, Extraocular Extension Melanoma, Iris Melanoma, Metastatic Intraocular Melanoma
- Trial name
- NCT00450255
- Testing
- ziv-aflibercept, pharmacological study
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer Metastatic
Cap+Bev vs Cap+Iri+Bev 1st-line Therapy in mCRC
Patient with multiple metastases, not eligible for surgery, might not profit from intensive chemotherapy regimens. Therefore less intensive regimens focusing on survival and disease control may be a better choice for first line…
- Trial name
- NCT01249638
- Testing
- Capecitabine, Bevacizumab, Irinotecan
- Where
- Germany
- Volunteers
- 516 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cataract, Pseudoexfoliation Syndrome
Long-term Intraocular Lens (IOL) Decentration and Tilt in Eyes With Pseudoexfoliation Syndrome (PES) Following Cataract Surgery
To evaluate long-term intraocular lens (IOL) decentration and tilt in eyes with pseudoexfoliation syndrome (PES) following cataract surgery using Visante anterior segment OCT and iTrace Visual Function Analyzer.
- Conditions
- Cataract, Pseudoexfoliation Syndrome, Pseudophakia
- Trial name
- NCT03453827
- Testing
- no intervention
- Volunteers
- 37 people
- Sponsor
- Hospital Hietzing
Infertility
Predictors of Pregnancy Rate in Assisted Reproductive Technology According to Actual Guidelines
Goals: To explore the association of probability of pregnancy with certain prognostic factors in patients undergoing assisted reproductive technology in Russian population according to international and national guidelines.
- Trial name
- IRIS (NCT04249297)
- Testing
- Duphaston® (Dydrogesteron)
- Where
- 52 sites in Kazakhstan, Russia
- Volunteers
- 1,150 people
- Sponsor
- Abbott
Metastatic Gastric Adenocarcinoma, Second Line
Ramucirumab (Cyramza), Nal-IRI (ONIVYDE) and Trifluridine/Tipiracil (Lonsurf) in Second Line Metastatic Gastric Cancer .
Primary Objectives In phase 1b cohort, to determine MTD (maximum tolerated dose) of nal-IRI (ONIVYDE®) in combination with Ramucirumab (Cyramza®) and TAS-102 (LONSURF®) In phase II cohort, to evaluate disease objective response…
- Conditions
- Metastatic Gastric Adenocarcinoma, Second Line, Chemotherapy
- Trial name
- NCT05927857
- Testing
- nal-IRI /Experimental, Ramucirumab /Experimental, Trifluridine/Tipiracil /Experimental
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Health Research Institutes, Taiwan
Corneal Endothelial Cell Loss, Pseudoexfoliation Syndrome
Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation Syndrome
To study corneal endothelial cells changes after phacoemulsification in patients with senile cataract and pseudoexfoliation syndrome (PEX) compared with control patients with senile cataract using specular microscope.
- Trial name
- NCT05447130
- Testing
- phacoemulsification
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Eye Cyclorotation Degree, Pupil Shift
Evaluation of Position-induced Cyclorotation Between Wavefront Measurement and Refractive Surgery by the Iris Registration Method
Cyclorotation of eyes may be affected by motion and orientation of the head and body. An automated alignment method with the technique of iris recognition was used to assess the amount and orientation of position-induced…
- Trial name
- NCT00943163
- Where
- Taiwan
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Chronic Kidney Disease(CKD), Type 2 DM
Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)
IRIS-CKD is a two-program implementation study to improve guideline-recommended screening and treatment of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.
- Conditions
- Chronic Kidney Disease(CKD), Type 2 DM, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- IRIS-CKD (NCT06906640)
- Testing
- (IRIS-CKD Management Program): Education, (IRIS-CKD Management Program): GDMT
- Where
- 7 sites in United States
- Volunteers
- 212 people
- Sponsor
- Duke University
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Open-angle Glaucoma, Ocular Hypertension
Phase 4 Study Comparing IOP Lowering in OAG or OH in Caucasian or Japanese Subjects C-02-32
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after six weeks of treatment in Caucasian and Japanese subjects.
- Trial name
- NCT00047606
- Testing
- IOP Lowering Medications
- Volunteers
- 84 people
- Sponsor
- Alcon Research
Coronary Artery Disease
Evaluation of Effectiveness and Safety of BIOMATRIX Stent (IRIS-BIOMATRIX)
The objective of this study is to evaluate effectiveness and safety of BioMatrix stent in the "real world" daily practice as compared with first-generation drug-eluting stents (sirolimus- or paclitaxel-eluting stents).
- Trial name
- NCT01350778
- Where
- 20 sites in South Korea
- Volunteers
- 837 people
- Sponsor
- Seung-Jung Park
Pseudoexfoliation Syndrome, Carpal Tunnel Syndrome (CTS)
Pseudoexfoliation and Carpal Tunnel Study
This prospective, single-center case-control study aimed to investigate the association between pseudoexfoliation syndrome (PES) and carpal tunnel syndrome (CTS) using biochemical markers.
- Trial name
- NCT06946030
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Pseudoexfoliation Syndrome
Optical Low Coherence Reflectometry Enables Preoperative Detection of Zonular Weakness in Pseudoexfoliation Syndrome
The purpose of the study was to evaluate optical ocular components in patients with pseudoexfoliation syndrome using optical low coherence reflectometry.
- Trial name
- NCT01298895
- Where
- Croatia
- Volunteers
- 224 people
- Sponsor
- General Hospital Sveti Duh