Clinical trials: Irisin
Gestational Diabetes Mellitus, Neurodevelopmental Disorders
n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
This study aims to investigate the associations of maternal nutritional status during pregnancy and postpartum periods with postpartum abnormal glucose metabolism in Guangzhou pregnant women.
- Conditions
- Gestational Diabetes Mellitus, Neurodevelopmental Disorders, Postpartum Abnormal Glucose Metabolism, Child Growth and Development
- Trial name
- NCT03023293
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,122 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Serum and Corporal Irisin in Diabetic Patients With Erectile Dysfunction
Serum and Corporal Irisin Level and Its Correlation With Erectile Function in Diabetic Obese Patients
Obese and diabetic men constitute a huge fraction of ED patients. There is established relation between both obesity ,diabetes and ED through multiple neuroendocrine and vascular players .
- Trial name
- NCT06696599
- Testing
- Serum and corporal irisin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Exercise Physiology, Cognitive Function
Jackfruit Effects on Adipokines and Cognition in Boxers
This study investigates the effects of jackfruit oil extract on adipokine levels (Irisin, Omentin-1), brain-derived neurotrophic factor (BDNF), cognitive performance, and body measurements in healthy young boxers aged 18-25.
- Conditions
- Exercise Physiology, Cognitive Function, Adipokine Response, Brain-Derived Neurotrophic Factor (BDNF)
- Trial name
- NCT07268976
- Testing
- Jackfruit Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bayburt University
Irisin, Lactate
Effects of Different Types of Exercise on Irisin and Cognitive Performance (Exercise-Irisin)
Purpose The purpose of this study was to determine the acute effects of different exercise intensities on Irisin levels, trail making test performance, and feeling scale.
- Conditions
- Irisin, Lactate, Cognitive Function, Exercise Training
- Trial name
- Ex-Irisin (NCT07146490)
- Testing
- Low Exercise, Long Interval Exercise, Short Intevral Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Postoperative Pain After Endodontic Treatment, Dental Anxiety
Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment
Some people feel pain after a root canal treatment. This study will test whether intracanal cryotherapy, a final rinse of the tooth with cold sterile saline, can reduce this pain compared with a room-temperature rinse.
- Conditions
- Postoperative Pain After Endodontic Treatment, Dental Anxiety, Root Canal Treatment
- Trial name
- CRYO-IRISIN (NCT07889050)
- Testing
- Intracanal cryotherapy, Standard room-temperature irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Prader Willi Syndrome
Post Exercise Irisin Levels in PWS Patients
Post exercise irisin levels in PWS patients Obesity, short stature, hypogonadism, hypotonia and impaired cognition are the major clinical features of Prader-Willi syndrome (PWS), a complex neurogenetic disorder due to lack of…
- Trial name
- NCT02728544
- Testing
- exercise and blood tests
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Polymorphosis, Cognitive Function
Effect of Gene Polymorphism on Cognitive Function
The goal of this observational study is to study the effect of gene polymorphism on cognitive improvement in response to exercise in healthy participants.
- Trial name
- NCT05879341
- Testing
- High intensitiy interval training
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Healthy Subjects
Circulating Levels of Irisin in Healthy Young Subjects
Irisin, a newly discovered myokine induced in exercise, has potential effects in stimulating adipose tissue browning, fighting obesity and diabetes.
- Trial name
- IRISSAS (NCT01986530)
- Testing
- Boost, Aerobic exercise
- Where
- Greece
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- 424 General Military Hospital
Physical Activity
Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin
This study investigates the brown adipose tissue (BAT) activation and metabolism using positron emission tomography (PET) imaging before and after exercise training intervention at fasting state under normal room temperature and…
- Trial name
- EXEBAT (NCT03359824)
- Testing
- Exercise
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Irisin, Endothelial Dysfunction
The Relation Between Plasma Irisin Level and Endothelial Dysfunction in Type 2 Diabetes
Irisin is a signaling protein that is released into the blood from skeletal muscle after proteolysis of the membrane protein FNDC5 . FNDC5, encoded by the Fndc5 gene.
- Conditions
- Irisin, Endothelial Dysfunction, Type 2 Diabetes
- Trial name
- NCT01877603
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Metabolically Healthy Obesity
Brown Fat Tissue Related Hormone Levels in Metabolically Healthy and Unhealthy Obese Individuals
There are two types of adipose tissue in humans, white and brown adipose tissue. While the main task of white adipose tissue is energy storage, the main task of brown adipose tissue is energy expenditure.
- Trial name
- NCT05232695
- Testing
- metabolically healthy obese
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Acne Vulgaris
Effect of Systemic Isotretinoin on Serum Irisin Level in Acne Vulgaris Patients
Acne vulgaris is a chronic inflammatory skin disease affecting the pilosebaceous unit. It is clinically characterized by comedones, papules, pustules, nodules, cysts and scarring on the face and trunk.
- Trial name
- NCT05869188
- Testing
- Isotretinoin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- South Valley University
Obesity
The Irisin and Metabolic Exercise Training Study
It has been established that greater amounts of vigorous intensity physical activity lead to improved health outcomes. Interestingly, the response of biologically active substances, called myokines, differs according to exercise…
- Trial name
- iMET (NCT03514238)
- Testing
- High Intensity Interval Aerobic Exercise (HIIT), Continuous Moderate Aerobic Exercise (MOD), Control Sitting Condition (C)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Inflammatory Response, Periodontitis
Saliva Irisin Level is Higher and Related With Interleukin 6 in Generalized Periodontitis
Irisin is novel adipomyokine known as a mediator of physical activity that produced mainly by skeletal muscle and adipose tissues.
- Trial name
- NCT05474820
- Testing
- Samples collection and ELISA analyses, Evaluating periodontal paramètres
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Memory Deficits, Aging
The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.
The aim of this project is to estimate the effects of therapy with dance and movement and Tai Chi on irisin plasma levels, a myokine with proven neuroprotective effects, in the context of baseline levels of cognitive function and…
- Conditions
- Memory Deficits, Aging, Cognitive Impairment, Physical Activity
- Trial name
- NCT05363228
- Testing
- Therapy by Dance and Movement, Tai Chi
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Healthy
Circulatory Levels of Irisin in Response to Chronic Resistance Training
Study the responses of circulatory irisin to chronic high-intensity resistance training
- Trial name
- NCT02475473
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Periodontal Health, Gingivitis
Salivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis
This observational cross-sectional study aims to compare the levels of irisin, interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) in saliva and gingival crevicular fluid (GCF) among individuals…
- Conditions
- Periodontal Health, Gingivitis, Periodontitis
- Trial name
- NCT07881406
- Testing
- Clinical periodontal examination, ELISA-based biomarker analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Healthy Adult, Athlete
The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis
The purpose of this study is to investigate the effects of an acute aerobic exercise on irisin, klotho, sirtuin-1, and BDNF levels in the healthy adults.
- Trial name
- NCT07800156
- Testing
- Aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cemre Didem Eyipinar
Periodontal Diseases
The Effect of Non-Surgical Periodontal Treatment on Bone Metabolism in Type 2 Diabetes and Systemically Healthy Individuals
In this study, it was concluded that sclerostin and irisin may be alternative markers for evaluating the effectiveness of periodontal treatment and healing of periodontal tissues by affecting bone metabolism.
- Trial name
- NCT05862311
- Testing
- ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University