Clinical trials: Iron Bioavailability
Iron-deficiency Anemia
Iron Fortified Beverages and Application in Women Predisposed to Anemia
The objective of the study is to know if consumption of an iron fortified fruit juice containing micronized iron pyrophosphate, is useful to increase iron status in women predisposed to iron deficiency anemia.
- Trial name
- FeDrink (NCT01135576)
- Testing
- non-fortified fruit juices consumed as part of the usual diet, Iron fortified fruit juice
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Anemia
A Functional Food for the Prevention of Iron-deficiency Anemia
It has been estimated that 1 in 2 women expecting a baby will be diagnosed with iron deficiency. In turn iron deficiency can affect the health and wellbeing or both mother and child.
- Trial name
- NCT01055431
- Testing
- Control bread, Teff Bread
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Iron-deficiency, Iron Deficiency Anemia
IP Peru, Bioavailability of Iron From Potatoes
To combat iron deficiency in Low and Middle-Income Countries, sustainable food-based solutions have to be implemented to serve populations, not only individuals.
- Conditions
- Iron-deficiency, Iron Deficiency Anemia, Iron Deficiency (Without Anemia)
- Trial name
- IPPERU (NCT04216030)
- Testing
- High Fe IP meal labelled with Fe-58, Control OFSP meal labelled with Fe-57
- Where
- Peru
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron-deficiency
Effect of Polyphenols on Iron Absorption From Finger Millet
In India, one of the fast growing countries, 53% of all women have anaemia as per the National Family Health Survey. A recently published study on the burden of disease in India concluded that the burden of Iron deficiency…
- Trial name
- NCT04194567
- Testing
- Black Ragi, White Ragi
- Where
- 2 sites in Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy
Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects
The primary purpose of this study is to compare the PK parameters of a single dose of a test tablet formulation of AKB-6548 relative to a single dose of the reference AKB-6548 tablet formulation, both treatments administered…
- Trial name
- NCT02412449
- Testing
- AKB-6548 tablet, reference formulation given in the fasted state, AKB-6548 tablet, test formulation given in the fasted state., AKB-6548 tablet, test formulation given in the fed state
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Iron-deficiency, Iron Deficiency Anemia
Iron Bioavailability From Biofortified Orange-fleshed Sweet Potato
To combat iron deficiency in Low and Middle-Income Countries, sustainable food-based solutions have to be implemented to serve populations, not only individuals.
- Trial name
- SASHA-II (NCT03840031)
- Testing
- High Fe OFSP meal labelled with Fe-58, Control OFSP meal labelled with Fe-57
- Where
- 2 sites in Malawi, Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency, Folic Acid Deficiency
Relative Bioavailability of Iron and Folic Acid in New Test Supplement
Deficiencies of iron and folic acid during pregnancy can lead to adverse outcomes for the fetus, thus supplements are recommended. Adherence to current tablet-based supplements is documented to be poor.
- Trial name
- NCT00789490
- Testing
- Daminaide 995 - SuppleFem Sprinkles, Materna
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Iron-deficiency
Iron Isotope Study of an Iron Fatty Acid Complex
The study aims at assessing the iron (Fe) bioavailability from a newly developed iron compound - an iron fatty acid complex. The iron from the compound is hypothesized to have a higher absorption rate than commonly available…
- Trial name
- IFAC (NCT03895424)
- Testing
- IFAC, MIFAC, Control Ferrous Sulfate
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron-refractory, Iron-deficiency Anemia (IRIDA)
Pharmacokinetics and Absolute Bioavailability of Fer-In-Sol and Triferic Administered Orally With Shohl's Solution in Healthy Volunteers
The main purpose is to determine the pharmacokinetics (PK) of Triferic iron administered orally in healthy adult volunteers. It is a randomized multiple treatments, single dose study.
- Trial name
- NCT02767128
- Testing
- Triferic, Fer-In-Sol, Shohl's solution
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rockwell Medical Technologies, Inc.
Iron-deficiency, Iron Deficiency Anemia
Cystatin SN Binds to Phytic Acid and Predicts Non-heme Iron Bioavailability
Phytic acid is a known inhibitor of iron bioavailability, although long term studies have suggested possibly exaggerated findings compared to single meal studies, pointing to phytic acid adaptation over time.
- Trial name
- NCT03030703
- Testing
- phytic acid
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Iron Absorption
Iron Absorption From Iron Enriched Aspergillus Oryzae in Females Using Stable Isotope Methodology
The objective of this study was to compare the iron absorption from ferric pyrophosphate enriched Aspergillus oryzae (ASP-p) to commonly used ferric pyrophosphate (FePP) and ferrous sulfate (FeSO4) when fortified in chicken…
- Trial name
- NCT03586245
- Testing
- Ferric pyrophosphate, Aspiron, Ferrous sulfate
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Iron Bioavailability
Iron Bioavailability From Fortified Food
Determination of fractional iron absorption from bouillon fortified with 3 labeled iron compounds.
- Trial name
- NCT02993835
- Testing
- Labeled iron salt Fe54, Labeled iron salt Fe57, Labeled iron salt Fe58
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Iron Deficiency Anemia, Iron-deficiency
Multiple Daily Condensed Tannin Supplementation and Iron Bioavailability: The Tannin Dose Response Trial
Tannins are known to inhibit iron absorption through formation of insoluble tannin-mineral complexes, and have thus been termed 'antinutritional.' Despite this, there is evidence that adaptation to similar antinutritional factors…
- Trial name
- NCT03030716
- Testing
- 95% condensed proanthocyanidins from grape seed extract
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Iron-deficiency
Sucrosom5al Iron Supplementation in Blood Donors
The aim of this descriptive/explorative pilot study is to examine the effects of supplementing a sucrosomial iron preparation in whole blood donors with iron deficiency for three months.
- Trial name
- NCT04250298
- Testing
- sucrosomial iron
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Iron-deficiency
Measuring Dietary Iron Absorption From Edible Insects and Assessing the Effect of Chitin Content on Iron Bioavailability (Study 2)
Due to the growing world population, there is a need to develop viable ecological and nutritional alternatives to animal food products.
- Trial name
- Sustironable2 (NCT05328141)
- Testing
- Bread and butter, X.gideon, X.gideon with ascorbic acid
- Where
- Switzerland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Generally Healthy
The Effect of a Short Term Exercise Schedule on Oral Iron Bio-availability and Iron Incorporation
Iron metabolism may undergo changes during exercise, with reductions in classical iron status markers due to a variety of postulated mechanism which include hemodilution, increased iron loss, hemolysis and increased iron storage…
- Trial name
- NCT01730521
- Testing
- Exercise (Running)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency
The Optimization of Iron Bioavailability of Supplements Using Hepcidin Levels in Humans
Background: Oral iron supplementation (OIS) is a widely-used strategy to treat iron deficiency anemia. However, absorption of OIS is often low and response is variable.
- Trial name
- NCT02050932
- Testing
- 60 mg Fe as FeSO4 with stable isotopic labels
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron-deficiency
Measuring Dietary Iron Absorption From Edible Insects and Assessing the Effect of Chitin Content on Iron Bioavailability (Study 1)
Due to the growing world population, there is a need to develop viable ecological and nutritional alternatives to animal food products.
- Trial name
- Sustironable1 (NCT04510831)
- Testing
- Refined maize with extrinsic addition of labelled FeSO4, T.molitor native chitin, T molitor reduced chitin
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Anemia; Deficiency, Nutritional, With Poor Iron Absorption
Fe Absorption in Mother and Child Pairs From Wheat Fortified With Iron With and Without Phenolic Containing Beverages
In Senegal, iron deficiency affects 39% of and 82% of women and children between 12 and 50 months indicating that iron deficiency is a major health problem.
- Trial name
- Fe_Senegal (NCT02437955)
- Testing
- Ferrous sulfate fortified bread with tea, ferrous sulfate fortified bread with water, Ferrous fumarate fortified bread with tea
- Where
- Senegal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy Volunteers
Iron Bioavailability From Dairy Product
Determination of fractional iron absorption from dairy product fortified with 2 labelled iron compounds
- Trial name
- NCT02585661
- Testing
- Dairy product fortified with enriched Fe-54 salt (1), Dairy product fortified with enriched Fe-57 salt (2)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)