Clinical trials: Irreversible Pulpitis
Irreversible Pulpitis
Effect of Using Different Concentrations of NaOCI on IL-8 Level
The objective is to compare various concentrations of NAOCL during Root canal treatment and their effect on IL-8 at the gingival crevicular fluid.
- Trial name
- NCT05277246
- Testing
- Irrigant concentration, NaOCI
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Symptomatic Irreversible Pulpitis
Effect of Preoperative Oral Tramadol on Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis
Aim: The purpose of this prospective, randomized, double-blind, controlled study was to compare the preoperative oral tramadol medication with ibuprofen and acetaminophen on the success of inferior alveolar nerve blocks (IANB) of…
- Trial name
- NCT04961268
- Testing
- TraMADol 50 Mg Oral Tablet, Tramadol 100 MG Oral Tablet, Ibuprofen 600Mg Tab
- Where
- Saudi Arabia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Alfarabi Colleges
Pulpitis
Oral Glucocorticoids Effect on Post Endodontic Pain
The aim of this single-center randomized, double-blind, placebo-controlled clinical trial is to assess the effect of preoperative, single, oral dose of prednisolone on postoperative pain and medication intake in patients with…
- Trial name
- NCT02819648
- Testing
- Prednisolone, Control
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Post-Op Complication
Effect of Occlusal Reduction on Relief of Pain and Sensitivity to Percussion in Patients With Irreversible Pulpitis
One of the most important aspects of endodontic practice is to abate pain during and post root canal treatment. An endodontist by all means should provide a painless endodontic treatment to their patients.
- Trial name
- NCT05306535
- Testing
- Occlusal reduction
- Where
- Pakistan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Pain, Postoperative, Irreversible Pulpitis
Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial
The aim of this study was to evaluate the effect of continuous rotation and reciprocation kinematics on post operative pain and difference in substance P levels in patients with irreversible pulpitis with symptomatic apical…
- Conditions
- Pain, Postoperative, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT06081335
- Testing
- EdgeEndo x7 continuous rotation files, EdgeOne Fire reciprocating files
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Lower Molars With Irreversible Pulpitis
EFFECTS OF IRRIGATION NEEDLES WITH DIFFERENT DESIGNS USED DURING ENDODONTIC TREATMENT ON POSTOPERATIVE PAIN
This study is aimed to comparatively evaluate the effects of different irrigation needle designs used during endodontic treatment on postoperative pain and to provide information on which needle designs may be more advantageous…
- Trial name
- NCT07080918
- Testing
- Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Endodontic Treatment, Irreversible Pulpitis
A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment
The effect of Antibacterial Nanoparticles, Incorporated in root canal sealer material and in provisional restoration is going to be examined.
- Conditions
- Endodontic Treatment, Irreversible Pulpitis, Health Pulp, Infected Pulp
- Trial name
- IABN (NCT01167985)
- Testing
- IABN
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Endodontics, Pain
A Comparison of Two Different Single Doses of Prednisolone on Endodontic Inter-appointment Pain
The purpose of this prospective randomized, double-blind, placebo-controlled study is to compare the efficiency of 2 different single doses of pre-operative oral prednisolone (20 \& 40 mg) for the control of inter-appointment…
- Trial name
- NCT04481971
- Testing
- Prednisolone, lactose in capsules gelatin
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- King Saud University
Postoperative Pain
Effect of Passive Ultrasonic Irrigation Activation Cycle on Postoperative Pain
One of the most important goals of root canal treatment is to eliminate bacteria from infected canals. However, conventional irrigation methods combined with mechanical preparation applied during root canal treatment may not be…
- Trial name
- NCT06711029
- Testing
- Conventional needle irrigation, Passive Ultrasonic Irrigation with 3*20 sn, Passive Ultrasonic Irrigation with 6*10 sn
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Esin Özlek
Irreversible Pulpitis
Outcome Following Use of NaOCl and Chlorhexidine as Wound Lavage Agents
The goal of this clinical trial is to to compare effect of wound lavage agents NaOCl and Chlorhexidine on the outcome of partial pulpotomy in mature permanent posterior teeth with signs and symptoms indicative of irreversible…
- Trial name
- NCT06240130
- Testing
- Partial pulpotomy
- Where
- India
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulpitis - Irreversible, Tooth Decay
Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth
Of all the various pulpotomy medicaments that have been studied till to date, three agents have been selected for this study to compare their efficacy.
- Trial name
- NCT05266859
- Testing
- Calcium hydroxide, MTA, PRF
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Liaquat College of Medicine and Dentistry
Pulpitis - Irreversible
Comparison Between Intraligamentary Piroxicam and Articaine
Comparing the efficacy of intra-ligamentary Piroxicam and intra-ligamentary Articaine on pain during and after endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.
- Trial name
- NCT03612323
- Testing
- Intra-ligamentary Piroxicam, Intra-ligamentary Articaine
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis
Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block
Purpose: The aim of this prospective, double-blind, randomized controlled trial is to compare the effect of oral premedication of dexamethasone, ketorolac, meloxicam, ibuprofen or placebo on the success of inferior alveolar nerve…
- Trial name
- NCT05097768
- Testing
- Dexamethasone 0.5mg, Ketorolac 10 Mg Oral Tablet, Meloxicam 7.5 mg
- Where
- Saudi Arabia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Alfarabi Colleges
Pulpitis - Irreversible
Effect of Intrapulpal Injections on the Post-endodontic Pain
To achieve painless treatment in patients with a failed primary IANB, supplementary anesthesia has been advised. The majority of the studies evaluating intrapulpal injections have been performed on asymptomatic teeth.
- Trial name
- NCT06088446
- Testing
- Supplementary anesthetic injections
- Where
- India
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Pulpitis - Irreversible
Clinical and Radiographic Assessment of Bio C Repair, Biodentine and Mineral Trioxide Aggregate
The aim of this study is to assess Clinical and Radiographical effect of Bio C repair, Biodentine and Mineral Trioxide Aggregate when used as pulpotomy Agents in Immature Permanent Molars with Pulpits.
- Trial name
- NCT07522723
- Testing
- Biodentine, Bio C repair
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis - Irreversible
SCN9A Gene Expression and Inflammatory Cytokines
Voltage-gated sodium channels, especially Nav1.7 encoded by the SCN9A gene, are key regulators of nociceptive transmission. Upregulation of SCN9A has been associated with increased neuronal excitability and heightened pain…
- Trial name
- Gene Expressio (NCT07532200)
- Testing
- Inferior Alveolar Nerve Block
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Irreversible Pulpitis, Diabetes Mellitus, Type 2
Outcome of Complete Pulpotomy in Healthy and Type 2 Diabetic Patients in Permanent Teeth With Irreversible Pulpitis
Endodontic research on the effects of DM on pulp tissues is scarce. Diabetic human and animal histological research demonstrated a decreased reparatory response in the pulp, resulting in chronic pulp inflammation and reduced…
- Conditions
- Irreversible Pulpitis, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT06586775
- Testing
- Pulpotomy
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Anesthesia
Anesthetic Efficacy of X-tip Intraosseous Injection
Hypothesis: X-tip intraosseous is an effective supplementary injection in mandibular hot teeth as well as Periodontal Ligament (PDL) injection Purposes: Comparing the anesthetic efficacy of X-tip intraosseous and PDL injection in…
- Trial name
- NCT01214369
- Testing
- Type of Supplementary Injection
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Painful Irreversible Pulpitis
Effect of Fentanyl on the Rate of Anesthesia
Achievement of a deep and long-durated anesthesia is vital before most endodontic procedures; therefore, the investigators conducted this study to compare the local infiltration effect of epinephrine-containing lidocaine with/…
- Trial name
- NCT01794533
- Testing
- Lidocaine with Epinephrine+ Normal saline, Lidocaine with Epinephrine + fentanyl
- Where
- Iran
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj