Clinical trials: Ischemia, Myocardial
Angioplasty, Transluminal, Percutaneous Coronary, Coronary Artery Disease
Orsiro™ Drug Eluting Stent in Routine Clinical Practice
The purpose of this study is to evaluate effectiveness and safety of Orsiro™ Drug Eluting Stent in Routine Clinical Practice
- Trial name
- IRIS ORSIRO (NCT02039739)
- Testing
- Orsiro™ Drug Eluting Stent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,007 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease, Severe Coronary Artery Disease
Lithotripsy Versus Balloon Angioplasty for Optimal Treatment of CAlcified Lesions With and Without Optical Coherence Tomography evaluatION
Severely calcified coronary artery disease means that calcium has built up in the blood vessels that supply the heart. This makes coronary procedures more difficult and increases the risk of complications during and after…
- Conditions
- Coronary Artery Disease, Severe Coronary Artery Disease, Coronary Artery Calcification
- Trial name
- LOCATION (NCT07388030)
- Testing
- IVL Pretreatment + OCT-Guided Stent Implantation, IVL Pretreatment + Angiography-Guided Stent Implantation, Balloon Angioplasty (BA) Pretreatment + OCT-Guided Stent Implantation
- Where
- China
- Volunteers
- 3,060 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Myocardial Infarction
Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial.
The purpose of this study is to test whether early pre-reperfusion metoprolol administration in patients suffering and acute myocardial infarction might reduce the size of myocardial necrosis.
- Trial name
- METOCARD-CNIC (NCT01311700)
- Testing
- Injectable (i.v.) metoprolol tartrate (up to 15 mg).
- Where
- 12 sites in Spain
- Volunteers
- 221 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Coronary Disease
Sirolimus- and Paclitaxel-Eluting Stents for Small Vessels (ISAR-SMART-3)
The purpose of this study is to compare the efficacy of paclitaxel- and sirolimus-eluting stents to prevent re-blockage of small coronary arteries
- Trial name
- NCT00146575
- Testing
- Sirolimus-eluting stent (Cypher), Paclitaxel-eluting stent (Taxus)
- Where
- 2 sites in Germany
- Volunteers
- 360 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Ischemic Heart Disease, Lung Injury
Effect of Human Umbilical Cord-derived Mesenchymal Stem Cells on Non-cardiac Surgery-induced Lung Injury
This study is an exploratory clinical study to observe the improvement of lung function before and after the treatment by human umbilical cord-derived mesenchymal stem cells, and the purpose is to evaluate the safety and…
- Conditions
- Ischemic Heart Disease, Lung Injury, Non-cardiac Surgery
- Trial name
- NCT04996966
- Testing
- human umbilical cord-derived mesenchymal stem cells, saline
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Shanghai East Hospital
Myocardial Ischemia
Pressure Guidewire System Multi-center, Prospective, Self-Control, Clinical Trial
Patients with intermediate-grade coronary stenosis undergo measurement of fractional flow reserve using the test article (Zurich Pressure Guidewire System) and predicate article (Abbott PressureWire System).
- Trial name
- NCT04582877
- Testing
- FFR measurement
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zurich Medical Inc.
Heart Valve Diseases, Cardiac Surgical Procedures
Assessment of Transnational Performance of the Universal Cardiac Surgical Risk Score Across International Sites
ATLAS is a prospective, observational, multicenter cohort study of how accurately the Universal Cardiac Surgical Risk Score (UCSRS) predicts 30-day outcomes after adult cardiac surgery, compared head-to-head with two established…
- Conditions
- Heart Valve Diseases, Cardiac Surgical Procedures, Coronary Artery Disease
- Trial name
- ATLAS (NCT07920575)
- Testing
- Risk score calculation
- Volunteers
- 5,000 people
- Sponsor
- Union Health System
Microvascular Angina
Effect of ACE-Inhibition on Microvascular Function in Women With Assessed Microvascular Dysfunction
The aim of this study is to explore effects of long term treatment with ACE-inhibitor on the small vessel function assessed by coronary flow reserve (CFR) by transthoracic echocardiography and flow mediated dilation in…
- Trial name
- NCT02525081
- Testing
- Ramipril (ACE-inhibitor)
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- Bispebjerg Hospital
Angina, Unstable, Myocardial Infarction
Heart Function and Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
This study will examine the relationship between certain measures of heart function and exercise capacity in patients with hypertrophic cardiomyopathy (HCM).
- Conditions
- Angina, Unstable, Myocardial Infarction, Ischemic Heart Disease
- Trial name
- NCT00354328
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Disease
PCI Alternative Using Sustained Exercise
Cardiovascular disease remains the leading cause of morbidity and mortality in the U.S. and is a major cause of disability in Veterans. Most of these deaths are due to coronary artery disease (CAD).
- Trial name
- PAUSE (NCT03520400)
- Testing
- Exercise Therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Acute Coronary Syndrome, Heart Failure
International CR Registry
The ICRR is a health services registry to establish the quality of CR delivery, and the effectiveness in terms of patient outcomes, in low-resource settings.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Coronary Artery Disease
- Trial name
- ICRR (NCT04676100)
- Testing
- Cardiac rehabilitation
- Where
- Qatar
- Volunteers
- 7,000 people
- Sponsor
- University Health Network, Toronto
Cardiovascular Diseases, Coronary Disease
Natural History of Coronary Heart Disease
To examine the natural history of mortality due to coronary heart disease in post-myocardial infarction patients from the Beta-Blocker Heart Attack Trial (BHAT) and the Aspirin Myocardial Infarction Study (AMIS).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005265
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndrome (ACS)
Safety Study of Apixaban in Recent Acute Coronary Syndrome
The purpose of this clinical research study is to determine whether apixaban will be safe in people who have recently had unstable angina or a heart attack.
- Trial name
- NCT00313300
- Testing
- Apixaban
- Where
- 151 sites in United States, Austria and 12 more
- Volunteers
- 1,741 people
- Sponsor
- Bristol-Myers Squibb
Asthma, Coronary Artery Disease
A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease
This study is intended to determine the safety and tolerance of regadenoson in subjects with asthma or chronic obstructive pulmonary disease.
- Conditions
- Asthma, Coronary Artery Disease, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00862641
- Testing
- Regadenoson
- Where
- 48 sites in United States
- Volunteers
- 1,009 people
- Sponsor
- Astellas Pharma Inc
STEMI
Comparison Between Two Revascularization Strategies in MVD Patients With Uncomplicated ST-elevation MI
The study aimed to compare major adverse cardiac and cerebrovascular events(MACCE) and mortality at one year between two strategies: complete revascularization including non-culprit lesions percutaneous coronary intervention(PCI)…
- Trial name
- Promise (NCT04582175)
- Testing
- angioplasty
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- University of Oradea
Myocardial Infarction
The Impact of Early Follow-up on Readmission Rates in AMI Patients
With no prior prospective study to demonstrate the benefit of an early post-discharge follow-up appointment in reducing readmission rates in the post-myocardial infarction (MI patient population, we propose to conduct the first…
- Trial name
- NCT02276456
- Testing
- Follow-up Appointment- early vs standard
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Duke University
Angina, Stable
Effectiveness of Inspiratory Muscle Training in Patient With Stable Angina
Stable angina is a cardiac pathology that adversely affects the quality of life of the patient, which develops as a result of narrowing of the coronary vessels developing in atherosclerotic ground and / or impaired oxygen…
- Trial name
- NCT03923153
- Testing
- Inspiratory muscle training with PowerBreathe (IMT Technologies Ltd., Birmingham,England)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Mustafa Kemal University
Recurrent Ventricular Tachycardia
Ventricular Tachycardia (VT) Ablation or Escalated Drug Therapy
This study will compare aggressive antiarrhythmic therapy to catheter ablation for ventricular tachycardia in patients who have suffered prior myocardial infarction.
- Trial name
- VANISH (NCT00905853)
- Testing
- Catheter Ablation, Escalated Antiarrhythmic Therapy
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- John Sapp
Coronary Artery Disease
OCT Evaluation of Early Healing of EPC Capturing (GENOUS) Stent (EGO Study)
All patients who have received GENOUS stent implantation at Queen Mary Hospital for treatment of ischemic heart disease are eligible for this study.
- Trial name
- EGO (NCT01272895)
- Testing
- Coronary Intervention (GENOUS stent)
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- Prof. Stephen Lee
Heart Failure
The Effects of Sacubitril/Valsartan Compared to Valsartan on LV Remodelling in Asymptomatic LV Systolic Dysfunction After MI
Prior to reperfusion therapy, the major therapeutic breakthrough in myocardial infarction was the demonstration that ACE inhibitors or ARBs, given to prevent adverse "remodelling" (progressive dilatation and decline in systolic…
- Trial name
- RECOVER-LV (NCT03552575)
- Testing
- sacubitril/valsartan, Valsartan
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people
- Sponsor
- NHS Greater Glasgow and Clyde
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