Clinical trials: Ischemia, Myocardial
Endothelial Dysfunction, Atherosclerosis
Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries
The investigators are hoping to discover the cause of chest pain in patients with a normal coronary arteriogram. For patients with chest pain coronary angiography is the standard method by which the blood vessels of the heart can…
- Conditions
- Endothelial Dysfunction, Atherosclerosis, Inflammation, Myocardial Ischemia
- Trial name
- ACOVA (NCT01162824)
- Testing
- Acetylcholine, Adenosine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's Healthcare NHS Trust
Myocardial Ischemia
Precision of the Magnetocardiographer for Data Aquision and Analysis.
magnetocardiography has been extensively studied focusing on the possible clinical applications of the device. Evaluating the precision of a device is a prerequisite condition to know what are significant changes and how can…
- Trial name
- NCT00170014
- Testing
- Magnetocardiograph
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Myocardial Ischemia
Safety and Efficacy of MCG for Diagnosing Coronary Heart Disease
A magnetocardiograph (MCG) is a medical device capable of recording the magnetic fields that arise from the electrical activity of the heart.
- Trial name
- NCT00170027
- Testing
- Magnetocardiograph
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Myocardial Ischemia, Exercise
Exercise-induced Changes in Cardiac Function & Morphology
Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity.
- Conditions
- Myocardial Ischemia, Exercise, Myocardial Contraction, Myocardial Stunning
- Trial name
- NCT01179802
- Testing
- Strenuous Endurance exercise
- Where
- Switzerland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Myocardial Ischemia
A Clinical Evaluation of the ProNOVA XR Polymer Free Drug Eluting Coronary Stent System
The objective of this study is the assessment of the performance, safety and efficacy of the ProNOVA XR Polymer Free Drug Eluting Stent System in the treatment of patients with de novo native coronary artery lesions.
- Trial name
- EURONOVA (NCT01151033)
- Testing
- Drug Eluting Stent implantation
- Where
- 3 sites in Poland
- Volunteers
- 50 people
- Sponsor
- KCRI
Perfusion Imaging, MRI
MRI Perfusion Imaging at 3Tx Compared to Invasive FFR Measurements
Coronary artery disease (CAD) has a great significance concerning prevalence and mortality in the western world. It is usually diagnosed by catheterization and coronary arteries are visually assessed by the examiner.
- Conditions
- Perfusion Imaging, MRI, Myocardial Fractional Flow Reserve, Myocardial Ischemia
- Trial name
- Vision MRT (NCT01277055)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heart Center Bogenhausen
Old Myocardial Infarction, Chronic Myocardial Ischemia
Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac Surgery
This prospective, randomized, placebo-controlled study was designed to assess the safety, feasibility and efficacy of intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe, chronic ischemic…
- Conditions
- Old Myocardial Infarction, Chronic Myocardial Ischemia, Left Ventricular Dysfunction
- Trial name
- NCT01267331
- Testing
- bone marrow mononuclear cells injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Ischemia
FOCUS:Focus On Coronary Unstable Syndromes
Study objectives: To demonstrate that the acute administration of ramipril will control the inflammation process in patients with high-risk Acute Coronary Syndrome (ACS) as assessed by the high sensitivity C-reactive protein…
- Trial name
- NCT00268619
- Testing
- Ramipril
- Sponsor
- Sanofi
Ischemic Heart Disease
Comparison Between Everolimus-eluting Stent (EES) and Sirolimus-eluting Stent (SES) in the Bifurcation Lesion
In study-1, the purpose of this study is to compare the long-term outcome of provisional stenting between EES and SES deployment.
- Trial name
- J-REVERSE (NCT01266239)
- Testing
- kissing balloon inflation, EES vs. SES
- Where
- 5 sites in Japan
- Volunteers
- 300 people
- Sponsor
- Shin Yukuhashi Hospital
Hypertension, Myocardial Ischemia
Perioperative Myocardial Ischemia in Isolated Systolic Hypertension
During or after surgery, patients may suffer heart attacks or other heart complications, increasing the hospital stay by 11 days on average and costing an estimated US$20 billion in 1990.Many risk factors have been identified but…
- Trial name
- PROMISE (NCT01237652)
- Where
- Canada
- Volunteers
- 312 people
- Sponsor
- Ottawa Hospital Research Institute
Coronary Disease, Coronary Artery Disease
SPIRIT V: Post-marketing Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System in Europe
The purpose of this Clinical Evaluation is a continuation in the assessment of the performance of the XIENCE V® Everolimus Eluting Coronary Stent System (XIENCE V® EECSS) in the treatment of patients with de novo coronary artery…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- SPIRIT V (NCT00402272)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent
- Where
- 93 sites in Austria, Belgium and 21 more
- Volunteers
- 2,700 people
- Sponsor
- Abbott Medical Devices
Myocardial Ischemia, Congestive Heart Failure
Stem Cell Study for Patients With Heart Failure
The purpose of this study is to determine if cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will improve your ejection fraction…
- Conditions
- Myocardial Ischemia, Congestive Heart Failure, Cardiovascular Disease
- Trial name
- NCT00346177
- Testing
- Autologous Stem Cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Losordo, Douglas, M.D.
Atherosclerosis, Coronary Artery Disease
Study of Near Infrared Spectroscopy (NIRS) and Intravascular Ultrasound (IVUS) Combination Coronary Catheter
This study is designed to evaluate the technical performance and clinical handling of a coronary catheter that includes two imaging techniques.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Myocardial Ischemia, Myocardial Infarction
- Trial name
- SAVOIR (NCT00901446)
- Testing
- Intravascular ultrasound and spectroscopy
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Infraredx
Ischemic Heart Disease
Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)
Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations.
- Trial name
- NCT01041742
- Testing
- fluid loading
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction, Ischemia
FIT (Fast Infarction Treatment): Complete Revascularization During Primary Percutaneous Coronary Intervention (PCI) Can be Achieved Safely With an Improved Clinical Outcome During the Indexed Hospitalization.
Few reports described outcomes of complete compared with infarct related artery (IRA) only revascularization in patients with ST elevation myocardial infarction (STEMI) and multivessel coronary disease (CAD).
- Conditions
- Myocardial Infarction, Ischemia, Heart Failure, Necrosis
- Trial name
- FIT (NCT01160900)
- Testing
- Coronary angioplasty all lesions
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Hypertrophy, Left Ventricular, Aortic Stenosis
Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left…
- Conditions
- Hypertrophy, Left Ventricular, Aortic Stenosis, Myocardial Ischemia, Cardiopulmonary Bypass
- Trial name
- NCT01144039
- Testing
- LG-group, HG-group
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University of Vienna
Ischemic Heart Disease, Cardiac Valve Disease
Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery
Hypotension frequently occurs during anesthesia induction. Preload decrease by anesthetics was often considered as one of main causes for this hypotension. However, the studies on this topic have been lacking.
- Trial name
- NCT01144546
- Testing
- passive leg raising (45 degree leg elevation for 1-2 min)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Hospital
Ischemic Heart Disease, Restenosis
Treatment of Bifurcation Lesions by SINGLE STENT and KISSing Balloon Trial
The use of DES have not diminished the need of improved treatment strategies , especially the treatment of bifurcation lesions still leave much to be clarified.
- Trial name
- SINGLEKISS (NCT00798954)
- Testing
- Sirolimus-eluting coronary stent (Cypher), Paclitaxel-eluting stent (TAXUS)
- Where
- 17 sites in Japan
- Volunteers
- 800 people
- Sponsor
- Vulnerable Plaque Society
Coronary Disease, Coronary Artery Disease
PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions
PROSPECT is a multi-center prospective registry of Acute Coronary Syndromes (ACS) patients with single or double vessel coronary artery disease.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- NCT00180466
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 697 people
- Sponsor
- Abbott Medical Devices
Ischemic Heart Disease
The Effect of Enhanced External Counter Pulsation on Left Ventricular Systolic and Diastolic Function
Enhanced external counter pulsation (EECP) is a procedure performed on patients with ischemic heart disease. The treatment improves physical capacity and relieves angina pectoris.
- Trial name
- NCT01112163
- Testing
- Enhanced external counter pulsation
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Herning Hospital