Clinical trials: Ischemia Reperfusion
Acute Ischemic Stroke
Optimizing Door-to-reperfusion Times of One-stop Management in Acute Ischemic Stroke
Time is one of the most important in the decision of treatment of acute ischemic stroke. The optimal One-stop management from admission to recanalization associated with reduction of in-hospital times.
- Trial name
- ORETOM (NCT05644938)
- Testing
- Standard workflow, One-stop
- Where
- Vietnam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Ischemia
The Effects of Preconditioning on Intramuscular High-Energy Phosphate Levels During Ischemia
Ischemia reperfusion injury may be reduced by ischemic preconditioning. This projects aims to show the effects of short and long time ischemic preconditioning (both sequences 3 x 5 minutes) during and after an ischemic period of…
- Trial name
- IPC in MRI (NCT00883467)
- Testing
- preconditioning, no preconditioning
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
Sitagliptin and Endothelial Dysfunction
Over the years, numbers of cardioprotective drugs have been evaluated to attenuate lethal ischemia-reperfusion (IR) injuries. There is little study whether sitagliptin protects against endothelial dysfunction induced by IR injury…
- Trial name
- NCT02406950
- Testing
- Sitagliptin
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
STEMI - ST Elevation Myocardial Infarction
Noninvasive Artificial Venous Stasis for Reperfusion in STEMI
This prospective, randomized study was designed to evaluate whether the noninvasive artificial venous stasis / RE-START procedure, administered prior to primary percutaneous coronary intervention, increases the frequency of…
- Trial name
- RE-START (NCT07689591)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Firat University
Myocardial Ischemic-reperfusion Injury
Immunometabolic Pattern of Intermittent Hypoxia During ST-segment Elevation Myocardial Infarction
The aim of this study is to characterize the protective pattern of intermittent hypoxia, angina pectoris and remote ischemic conditioning, in reperfusion injury by determining and monitoring the plasma immunometabolic parameters…
- Trial name
- NCT05230966
- Testing
- Remote Ischemic Conditioning (RIC)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Muscular Diseases
The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery
Single-centre observational study over one year investigating the mechanisms of muscle homeostasis in patients with acute skeletal muscle atrophy following major aortic surgery
- Trial name
- RIMMAS (NCT03354767)
- Testing
- Aortic and aortic valve surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Reperfusion Injury
Diagnostics for the Reperfusion Injury Following MI
The primary purpose of this study is to correlate new cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI) to biochemical parameters as the L-arginine-nitric oxide…
- Trial name
- NCT00529607
- Testing
- contrast echocardiography, 2D and 3D echocardiography, cardiac MRI
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Ischaemia Reperfusion Injury
Effect of Tea on Endothelial Function and Ischaemia-reperfusion Injury
Tea consumption may impact upon the decrease in endothelial function after IR-injury. However, no previous study directly examined the potential of tea to impact upon the change in endothelial function after IR-injury.
- Trial name
- NCT01660516
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischaemic Heart Diseases
Rotigaptide in Endothelial Dysfunction?
Arterial occlusion can lead to tissue ischemia and, if prolonged, end organ infarction. Clinical and experimental data would suggest that restoration of blood flow might trigger additional injury beyond that induced by the…
- Trial name
- NCT07192744
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Ischemia-Reperfusion Injury, Atherosclerosis
Does a Seven Day Treatment With Dipyridamole Induce Protection Against Ischemia-Reperfusion Injury?
This study is performed to determine whether a seven day treatment with dipyridamole (slow release, 200mg twice daily) can induce a protective effect against ischemia-reperfusion injury, after ischemic exercise of the…
- Trial name
- NCT00457405
- Testing
- dipyridamole
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy
Comparison of Two Devices Using Near-infra Red Spectroscopy During a Vascular Occlusion Test
Tissue oxygen saturation is non-invasively measured using near-infrared spectroscopy, by two device, INVOS®(somanetics Corporation, USA ) and InSpectra™ (Hutchinson Technology, USA).
- Trial name
- NCT01848977
- Testing
- vascular occlusion test
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Caffeine, Ischemic Preconditioning
The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion.
- Conditions
- Caffeine, Ischemic Preconditioning, Ischemia-Reperfusion Injury
- Trial name
- NCT00184912
- Testing
- caffeine, Technetium-TC99m-labeled Annexin A5, ten minutes forearm ischemia
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia/Reperfusion Injury
Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against…
- Trial name
- NCT00526695
- Testing
- Sevoflurane (Preconditioning)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ischemia Reperfusion Injury, Cardiovascular Disease
Does Atorvastatin Reduce Ischemia-Reperfusion Injury in Humans in-Vivo?
To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.
- Trial name
- NCT00441597
- Testing
- atorvastatin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy
Effect of Acupuncture to Endothelial Dysfunction Induced by Ischemia-reperfusion Injury
Some studies suggest that acupuncture improve flow mediated dilation (FMD) that represents endothelial function, but no study has investigated whether acupuncture protects against ischemia and reperfusion (IR)-induced endothelial…
- Trial name
- AURORAS (NCT02255006)
- Testing
- Active acupuncture, Euglucon 5mg, Celebrex 200mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Ischemia Reperfusion Injury, Endothelial Dysfunction
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Rationale: Apart from their cholesterol lowering effects, statins have cholesterol-independent pleiotropic actions, such as upregulation of 5'-ectonucleotidase and up-regulation of NO-synthase that may increase tolerance against…
- Trial name
- NCT00987974
- Testing
- rosuvastatin, atorvastatin 3 days, rosuvastatin 7 days
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hyperglycemia
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and…
- Trial name
- NCT00995670
- Testing
- 5% dextrose, Vitamin C, Simvastatin
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
NIRS, Tissue Oxygenation
CHECK-NIRS2D-Study
The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers.
- Conditions
- NIRS, Tissue Oxygenation, Microvascular Perfusion, Vascular Occlusion Test
- Trial name
- NCT07854431
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Reperfusion Injury, Vascular Complications
Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction
The aim of the study is to investigate the effect of dapagliflozin or placebo on acetylcholine (Ach)- or nitroglycerin (GTN)-induced vasodilation of the forearm resistance vasculature, as determined by FBF measurement before and…
- Trial name
- NCT05217654
- Testing
- Dapagliflozin 10mg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy Volunteers
Glucagon Like Peptide-1 in Remote Ischemic Conditioning
The study was designed to investigate whether glucagon like peptide-1 is a mediator of protection of endothelial function induced by remote ischemic conditioning in ischemia-reperfusion
- Trial name
- NCT02746757
- Testing
- Remote conditioning, Exendin 9-39
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet