Clinical trials: Ischemic Brain
Stroke, Stroke, Acute
Impact of COVID-19 Vaccines on Cerebrovascular Health
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Dementia
- Trial name
- NCT04992195
- Testing
- Laboratory tests and Montreal Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Arterial Calcification, Kidney Diseases
Aortic Calcification and Central Blood Pressure in Patients With Chronic Kidney Disease
Aim and background: This study will seek to identify physiological and biochemical factors explaining and predicting a higher than expected central (aortic) blood pressure (BP) in patients with chronic kidney disease (CKD).
- Conditions
- Arterial Calcification, Kidney Diseases, Coronary Artery Disease, Aortic Calcification
- Trial name
- ACCEPT (NCT04114695)
- Where
- Denmark
- Volunteers
- 185 people
- Sponsor
- Central Jutland Regional Hospital
Diabetes, Myocardial Infarction
Look AHEAD: Action for Health in Diabetes
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss.
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- LookAHEAD (NCT00017953)
- Testing
- Lifestyle Intervention, Diabetes Support and Education
- Where
- 18 sites in United States
- Volunteers
- 5,145 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation
A Study Evaluating Safety and Tolerability of YM150 Compared to Warfarin in Subjects With Atrial Fibrillation
The purpose of this study is to investigate the optimal daily dose and dose regimen of YM150 in subjects with non-valvular atrial fibrillation (NVAF), primarily based on safety and tolerability data.
- Trial name
- OPAL-2 (NCT00938730)
- Testing
- YM150, Warfarin
- Where
- 170 sites in Australia, Austria and 21 more
- Volunteers
- 1,280 people
- Sponsor
- Astellas Pharma Inc
Brain Injuries, Brain Ischemia
Evaluation of Patients Affected by Traumatic and Hypoxic-ischemic Brain Injury
According to the World Health Organization, perinatal asphyxia is the leading cause of severe neurological disabilities and the second leading cause of neonatal death among term infants, with an incidence of 3.94-5.12 per 1,000…
- Trial name
- PETRA (NCT06873477)
- Testing
- Gross Motor Function Classification System
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ischemic Stroke, Visual Field Defect
Norwegian Occipital Ischemic Stroke Study
Patients who suffer an ischemic stroke in the occipital lobe often experience Visual Field defects. Visual Field defects are negatively correlated to falling, institutionalisation, rehabilitation outcome and quality of life.
- Trial name
- NOR-OCCIP (NCT02307981)
- Testing
- Training with vision teacher (visual rehabilitation)
- Where
- 2 sites in Norway
- Volunteers
- 75 people
- Sponsor
- Haukeland University Hospital
Coronary Artery Disease
Serial OCT Evaluation of Tissue Coverage in Patients Submitted to Inspiron Drug Eluting Stent Implantation
Prospective, multicentric, single-arm study to evaluate fast and effective tissue repair in patients undergone percutaneous coronary intervention with drug eluting stent Inspiron.
- Trial name
- REPAIR (NCT03269461)
- Testing
- Angiography and Optical Coherence Tomography evaluations
- Where
- 5 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Scitech Produtos Medicos SA
Stroke, Ischemic
Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke
Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion.
- Trial name
- SUCRE (NCT06576466)
- Testing
- Creatine monohydrate
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Stroke, Stroke, Ischemic
Virtual Reality, Mood, and Sedentary Behaviour After Stroke
The purpose of this study is to: 1) evaluate the feasibility (e.g. recruitment and retention, administrative and participant burden) of a VR program to improve mood and sedentary behaviour in inpatient stroke survivors; and 2)…
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Lacunar
- Trial name
- NCT04011202
- Testing
- Virtual reality gaming program (VR-gaming program)
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of British Columbia
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) and warfarin for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03596502
- Testing
- Direct oral anticoagulants (DOACs), Warfarin
- Where
- Canada
- Volunteers
- 402,764 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Stroke
EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)
The primary hypothesis being tested in this trial is that ischaemic stroke patients selected with significant penumbral mismatch (according to imaging criteria) at 4.5 (or 3 hours depending on local guidelines) - 9 hours post…
- Trial name
- EXTEND (NCT01580839)
- Testing
- Tissue Plasminogen Activator (Alteplase)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Neuroscience Trials Australia
Stroke
Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke
It should be shown that Cerebrolysin in combination with Alteplase, the medication that should recover the blood flow through the brain, is an effective and save medication to treat ischeamic stroke.
- Trial name
- CERE-LYSE-1 (NCT00840671)
- Testing
- Cerebrolysin, 0.9% Saline Solution
- Where
- 15 sites in Austria, Croatia and 3 more
- Volunteers
- 119 people
- Sponsor
- Ever Neuro Pharma GmbH
Ischemic Stroke
Safety and Preliminary Efficacy of NXL-001 in Patients With Ischemic Stroke
This is a single-arm, open-label, single center, dose-escalation exploratory clinical study to evaluate the safety and tolerability of a single intracerebral injection of NXL-001, a NeuroD1 base gene therapy, in patients with…
- Trial name
- NXL-001 (NCT06761183)
- Testing
- intracerebral stereotactic injection of NXL-001
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Berlin - SPecific Acute Treatment in Ischemic or hAemorrhagic Stroke With Long Term Follow-up
The B-SPATIAL-Registry will provide a tool of quality assessment for stroke specific Treatments such as endovascular treatment. It will also enable the participating hospitals to compare the quality of care of their facility.
- Trial name
- B-SPATIAL (NCT03027453)
- Where
- Germany
- Volunteers
- 15,246 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Stroke, Ischemic
tDCS for Neurological Disability Among Subacute Stroke Survivors to Improve Multiple Domains in Quality of Life
Background: tDCS is an emerging noninvasive brain stimulation that triggers neuroplastic changes in the brain. To enhance motor and executive function, tDCS modifies neuronal activity.
- Trial name
- NCT06110169
- Testing
- Anodal Transcranial Direct Current Stimulation (Anodal tDCS)
- Where
- Saudi Arabia
- Volunteers
- 64 people
- Sponsor
- Karthick Balasubramanian
Stroke
Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke
The goal of this clinical trial is to test ischemic conditioning (blood flow restriction) as a neuromodulatory technique to improve gait function in stroke.
- Trial name
- NCT05906602
- Testing
- Real Ischemic Conditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Ischemic Stroke
Autologous Bone Marrow Mesenchymal Stem Cell Therapy for Ischemic Stroke
Stroke is a group of diseases mainly characterized by cerebral ischemia or hemorrhage, with a high fatality rate and disability rate. It has now become a major obstacle to social and economic development.
- Trial name
- ABMSC-IS (NCT06997939)
- Testing
- ABMSC
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Affiliated Hospital of Nantong University
Vertebrobasilar Ischemia
Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis
The purpose of this study is to investigate whether remote ischemic conditioning(RIC) would reduce the stroke risk of patients with symptomatic vertebrobasilar lesion of atherosclerosis,then we would observe the haemodynamics and…
- Trial name
- NCT02971462
- Testing
- ischemic conditioning
- Volunteers
- 80 people
- Sponsor
- Ji Xunming
Metabolic Syndrome, Coronary Artery Disease
Brain, Cardiac Hemodynamics and Cognition During Exercise in Subjects With Various Cardiovascular Profiles
People with cardiovascular risk (CV) factors (obesity, diabetes, etc...) or established heart disease (such as coronary heart disease or chronic heart failure) often have cognitive dysfunction as compared to people without CV…
- Conditions
- Metabolic Syndrome, Coronary Artery Disease, Heart Failure
- Trial name
- COGNEX (NCT03018561)
- Testing
- Exercise and Cognitive testing
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Insomnia, Ischemic Stroke
Adenosine A2a Receptor-Mediated Neuroinflammation in Remote Ischemic Conditioning for Post-Stroke Sleep Disorders
This is a single-center, prospective, randomized, double-blind, sham-controlled study. It will test whether remote ischemic conditioning (RIC), a non-invasive arm-cuff treatment, can improve insomnia after ischemic stroke and…
- Conditions
- Insomnia, Ischemic Stroke, Sleep Wake Disorders
- Trial name
- RIC-A2AR-SD (NCT07874594)
- Testing
- RIC Intervention Group
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Sichuan Academy of Medical Sciences
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