Clinical trials: Ischemic Conditioning
Hypoxic-Ischemic Encephalopathy
RIC in HIE: A Safety and Feasibility Trial
Remote Ischemic Conditioning has never been studied in neonates with HIE. However, RIC has been studied in animal models of perinatal asphyxia and has shown encouraging results.
- Trial name
- NCT05379218
- Testing
- Remote Ischemic Conditioning
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- The Hospital for Sick Children
Angina Pectoris, Myocardial Infarction
The Effect of Remote Ischemic Preconditioning on Major Organ Function in Patients With Coronary Artery Disease Undergoing Orthopedic Surgery
The investigators attempt to investigate the organ protective effect of remote ischemic conditioning in patients undergoing non-cardiac surgery with history of ischemic heart disease.
- Trial name
- RIPC-Angina (NCT02808936)
- Testing
- Remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Stroke
Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke
The current treatment based on evidence-based medicine for acute ischemic stroke mainly includes reperfusion (intravenous thrombolysis, mechanical thrombolysis), anti-platelet and stroke units.
- Trial name
- RICAMIS (NCT03740971)
- Testing
- Remote Ischemic Conditioning treatment, Guideline-based therapy
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- General Hospital of Shenyang Military Region
Multiple Sclerosis
Remote Ischemic Conditioning in PPMS
Progressive MS remains the most difficult therapeutic challenge. Remyelination is a promising therapeutic strategy but an effective pharmacologic intervention remains elusive.
- Trial name
- NCT06171334
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of Calgary
Moyamoya Disease, Remote Ischemic Conditioning
Remote Ischemic Conditioning in Adult Moyamoya Disease Patients
Remote ischemic conditioning (RIC) is a non-invasive therapeutic approach for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT05860946
- Testing
- Remote ischemic conditioning
- Volunteers
- 44 people
- Sponsor
- Huashan Hospital
Unilateral Cerebral Palsy, Hemiplegic Cerebral Palsy
Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence.
- Conditions
- Unilateral Cerebral Palsy, Hemiplegic Cerebral Palsy, Remote Ischemic Conditioning
- Trial name
- NCT05355883
- Testing
- Remote Ischemic Conditioning (RIC), Hand Arm Bimanual Intensive Therapy (HABIT), Bimanual Cup Stacking Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- East Carolina University
Platelet Function
Remote Ischemic Conditioning and Platelet Dysfunction
The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.
- Trial name
- NCT03125681
- Testing
- Remote ischemic conditioning, Control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Unruptured Intracranial Aneurysm, Infarction Cerebral
Chronic Remote Ischemic Conditioning in Small Infarctions Associated with Stent-assisted Coiling of Unruptured Intracranial Aneurysms
1. Disease Description Stent-assisted coiling has become an effective treatment modality for intracranial aneurysms. With continuous advancements in periprocedural antiplatelet regimens, the incidence of symptomatic…
- Trial name
- CRISIS (NCT06826144)
- Testing
- remote ischemic conditioning
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
ST Elevation Acute Myocardial Infarction
COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial
Remote ischemic conditioning (RIC) and intravenous exenatide administered immediately before primary angioplasty have been found to limit infarct size in patients with STEMI (ST segment elevation myocardial infarction), but the…
- Trial name
- COMBAT-MI (NCT02404376)
- Testing
- Exenatide, Remote Ischemic Conditioning (RIC)
- Where
- 6 sites in Spain
- Volunteers
- 378 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Ischemic Stroke, Cerebral Embolism and Thrombosis
Thrombolysis and RIPC in Acute Ischemic Stroke
Remote ischemic postconditioning (RIPC) is suggested to protect the cerebral cell against ischemia in various settings. However, the effect of RIPC in patients with acute ischemic stroke who undergo thrombolysis has yet to be…
- Trial name
- tripcais (NCT03218293)
- Testing
- RIPC device (IPC-906X)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy
Remote Ischemic Conditioning for Non-Proliferative Diabetic Retinopathy
The goal of this clinical trial is to evaluate whether remote ischemic conditioning (RIC) is a safe and effective treatment for non-proliferative diabetic retinopathy (NPDR) in adults aged 40-80 years with type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy, Remote Ischemic Conditioning, Diabetes Mellitus, Type 2
- Trial name
- RIC-NPDR (NCT06713720)
- Testing
- Remote Ischemic Conditioning Device
- Where
- 2 sites in China
- Volunteers
- 68 people
- Sponsor
- Xuxiang Zhang, MD
Moyamoya Disease, Pediatric
Safety and Efficacy of RIC in Pediatric Moyamoya Disease Patients Treated With Revascularization Therapy
Revascularization surgery has been the standard treatment to prevent ischemic stroke in pediatric Moyamoya disease (MMD) patients with ischemic symptoms.
- Trial name
- RIC-PMD (NCT03546309)
- Testing
- RIC group, Medication group
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Capital Medical University
Prehypertension, Remote Ischemic Conditioning
Safety and Feasibility of Remote Ischemic Conditioning on Prehypertension and Early-stage Hypertension
Nowadays, the incidence of stroke in China has reached 1.6‰, and this disease has become a primary cause of death in China. One of its major risk factors is hypertension.
- Conditions
- Prehypertension, Remote Ischemic Conditioning, Early Stage Hypertension
- Trial name
- NCT04254432
- Testing
- remote ischemic conditioning
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Peripheral Arterial Disease
RISCAID Study: Remote ISchemic Conditioning for Angiopathy In Diabetes
Objective The objective of this study is to investigate if long-term ambulatory remote ischemic conditioning can improve symptoms and signs of peripheral arterial disease in patients with type 2 diabetes.
- Trial name
- RISCAID (NCT02749942)
- Testing
- AutoRIC: Remote Ischemic Conditioning
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Steno Diabetes Center Copenhagen
Adult
Effects of RIC on Cognitive Function and Blood Oxygen Levels in Unacclimatized Adult at High Altitude
Several studies have shown cognitive impairment such as memory, perception and learning skill during ascent to high altitudes. However, few studies have directly investigated the effect of high altitudes exposure on attention-a…
- Trial name
- NCT03728114
- Testing
- RIC
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Retinal Artery Occlusion, Retinal Vein Occlusion
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT02898480
- Testing
- Remote ischemic conditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ischemic Preconditioning
Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Knee Osteoarthritis
Introduction: Musculoskeletal disorders have affected approximately 1.3 billion people worldwide. Evidence shows that chronic diseases and musculoskeletal conditions often occur together, and among them it is estimated that more…
- Trial name
- NCT05059652
- Testing
- Ischemic Preconditioning
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Paulista University
Enterocolitis, Necrotizing
Remote Ischemic Conditioning in Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) affects up to 10% of very preterm infants. NEC mortality is high (30-50 %) and has remained unchanged over the last decades. New treatments are urgently needed.
- Trial name
- NCT03860701
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
Hypertension, Vascular Diseases
The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults
The purpose of this study is to assess whether remote ischaemic conditioning, applied chronically, improves vascular health in older adults
- Trial name
- RIPCo (NCT05971407)
- Testing
- Remote Ischaemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nottingham