Clinical trials: Ischemic Disease
Sudden Hearing Loss, Ischemia
Ischemia- Modified Albumin Levels in the Sudden Hearing Loss
To evaluate ischemia-modified albumin levels in these patients to investigate the presence of ischemia in patients presenting with sudden hearing loss.
- Trial name
- IMA (NCT03706183)
- Testing
- Ischemia-modified albumin, Hearing thresholds
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Acute Mountain Sickness
Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide
The primary objective of the study will be to determine whether rapid remote limb ischemic preconditioning (RIPC) combined with acetazolamide can further reduce the incidence of acute mountain sickness (AMS) during the 6-hour…
- Trial name
- NCT05023941
- Testing
- Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days)
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Ji Xunming,MD,PhD
Coronary Artery Disease, Myocardial Infarction
Colchicine Cardiovascular Outcomes Trial (COLCOT)
The study evaluates whether long-term treatment with colchicine reduces rates of cardiovascular events in patients after myocardial infarction.
- Trial name
- COLCOT (NCT02551094)
- Testing
- colchicine
- Where
- Canada
- Volunteers
- 4,745 people
- Sponsor
- Montreal Heart Institute
Stroke, Depression
Poststroke Depression of Clinical Trial Registration
The investigators aim to explore the relationship between gut microbiota composition and earlier poststroke depression via 16S rRNA sequencing.
- Trial name
- IFEPSDAIS (NCT03863951)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Heart Failure, Iron Deficiencies
IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure
The aim of this study is to observe the effect of intravenous ferric derisomaltose in participants with non-ischaemic heart failure (LVEF<40%), iron deficiency (TSATS<20%) and established on heart failure therapy including…
- Trial name
- IRONHEART (NCT06542822)
- Testing
- Ferric derisomaltose
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Feasibility and Safety of Total Percutaneous Closure of Femoral Arterial Access Sites in the Veno-arterial ECMO Patients
The most frequent access site for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the common femoral artery (CFA), using either an open or percutaneous technique.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Myocarditis, Hypertension, Pulmonary
- Trial name
- NCT04689451
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Identification of Brain Injury Using Portable MRI
The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how…
- Trial name
- NCT07197918
- Testing
- portable MRI scanner
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention
Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction
This is a double-blind, multicenter, randomized, placebo-controlled clinical trial. It is planned to enroll patients admitted with anterior ST-segment elevation myocardial infarction (STEMI) within 6h of symptom onset and undergo…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, Cardioprotection
- Trial name
- COOPERATION (NCT04912518)
- Testing
- Dexmedetomidine (DEX)
- Where
- 9 sites in China
- Volunteers
- 250 people
- Sponsor
- Harbin Medical University
Cardiovascular Diseases, Coronary Disease
Aspirin-Myocardial Infarction Study (AMIS)
To determine whether the daily administration of 1 gm of aspirin to individuals with a documented myocardial infarction would result in a significant reduction in mortality over a three year period.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000491
- Testing
- aspirin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Limb Ischemia
Thrombolysis With Recombinant Non-immunogenic Staphylokinase vs Surgery in Patients With Acute Limb Ischemia FORAT Trial
Objective: to evaluate the efficacy and safety of intra-arterial intrathrombus administration of the recombinant non-immunogenic staphylokinase (Fortelyzin®) in patients with acute limb ischemia (ALI) vs surgery.
- Trial name
- FORAT (NCT05372718)
- Testing
- Recombinant non-immunogenic staphylokinase (Fortelyzin®), surgical methods of treatment
- Where
- 8 sites in Russia
- Volunteers
- 170 people
- Sponsor
- Supergene, LLC
Cerebral Ischemia
: External Shunt Versus Internal Shunt for Off Pump Glenn
A prospective, randomized comparative study where investigators present results of off pump bidirectional Glenn operation done using either a venoatrial shunt or external shunt to decompress superior vena cava during clamping.
- Trial name
- NCT05294718
- Testing
- Internal shunt, External shunt
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Angina Pectoris; Angiospastic
SCS for Vasospastic Angina Vasospastic Angina Pectoris - a Prospective Study
According to the 2020 Dutch guideline on chest pain (AP) without obstructive coronary artery disease, 70% of female and 30% of male patients undergoing a coronary angiogram (CAG), have no obstructive coronary artery disease.In…
- Trial name
- VAP (NCT06176391)
- Testing
- Spinal Cord Stimulation
- Volunteers
- 10 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Artery Disease
Detection of Coronary Artery Disease With Micro Electro-Mechanical Sensors
This study aims to validate the sensor data of gyroscope and accelerometer in detection of hemodynamically significant CAD.
- Trial name
- DECADE (NCT04290091)
- Where
- Finland
- Volunteers
- 930 people
- Sponsor
- Precordior Ltd
Ischemia, Angina
Comparison Of Left Ventricular Volume And Wall Stress With Dobutamine And Exercise Echocardiography
This study will compare the physiologic responses between exercise stress echocardiography and pharmacologic stress echocardiography on left ventricular volume and wall stress.
- Trial name
- NCT00774891
- Where
- United States
- Sponsor
- Lahey Clinic
Coronary Artery Disease
Safety of High-dose Tirofiban During Coronary Angioplasty
This single-centre study is intended to retrospectively check the safety of high-dose bolus of tirofiban in patients who underwent percutaneous angioplasty.
- Trial name
- SANTISS (NCT00566891)
- Testing
- tirofiban, Clopidogrel
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- S. Anna Hospital
Myocardial Ischemic Reperfusion Injury
Myocardial Protection and Anesthetic Agents
The aim of this study was to investigate the myocardial protective effects of remifentanil and dexmedetomidine in cardiac surgery.
- Trial name
- NCT02405689
- Testing
- Remifentanil, Dexmedetomidine, Sevoflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Ischemic Stroke, Hypercholesteremia
Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis
This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke.
- Trial name
- NCT07307989
- Testing
- statin + ezetimibe, Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Myocardial Infarction, Coronary Artery Disease
One-Time Complete Revascularization Versus Staged PCI in MVD During Pharmaco-Invasive STEMI Strategy
This study compares two treatment strategies in patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVD) undergoing a pharmaco-invasive approach after successful fibrinolysis.
- Trial name
- NCT07519590
- Testing
- One-Time Complete Revascularization, Staged Percutaneous Coronary Intervention
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Tanta University
Unstable Angina
Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.
This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type.
- Trial name
- NCT03171597
- Testing
- Anti-Platelet Drugs, Lipid Regulating Drugs, Coronary Vasodilator
- Volunteers
- 240 people
- Sponsor
- Jun Li
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