Clinical trials: Ischemic Disease
Heart Disease
EPIC (Evaluating Perioperative Ischemia Reduction by Clonidine)
In Canada 1 patient in 200 dies within 30 days of an operation. More than half of these deaths are the direct result of a heart related complication.
- Trial name
- NCT00335582
- Testing
- clonidine hydrochloride
- Where
- Canada
- Volunteers
- 165 people
- Sponsor
- University Health Network, Toronto
Coronary Artery Disease, Post Operative Pain
Ketorolac-an Option for Post Operative Pain Management After Elective Cardiac Surgery.
OBJECTIVE: The purpose of this study was to compare the efficacy of Ketorolac versus Paracetamol as an adjunct to Nalbuphine in the management of post-operative pain following elective cardiac surgery.
- Conditions
- Coronary Artery Disease, Post Operative Pain, Analgesia, Coronary Artery Bypass Grafting Surgery
- Trial name
- KOPAC (NCT05361824)
- Testing
- Ketorolac Injection, Paracetamol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Coronary Stenosis, Cerebral Stenosis
Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis
Intracranial atherosclerosis is common vascular lesion in Asian acute stroke patients and intracranial atherosclerosis patients have high rate of coronary artery disease (CAD).
- Trial name
- NCT02315924
- Testing
- simultaneous coronary and cerebral intervention, staged coronary and cerebral intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Myocardial Infarction, Diabetes Mellitus
Role of SGLT2I in Patients With Myocardial Infarction
Role of sglt2I in diabetic patients with myocardial infarction
- Trial name
- NCT06245980
- Testing
- SGLT2 inhibitor
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Dongying Zhang
Coronary Artery Disease
Comparison of Low-radiation Dose CT Angiography With Invasive Coronary Angiography in Stable Coronary Disease
This study is evaluating the performance of modern CT coronar angiography with low radiation technique compared to conventional invasive coronar angiography.
- Trial name
- NCT01476579
- Testing
- Cardiac Computer Tomography
- Where
- Norway
- Volunteers
- 769 people
- Sponsor
- University Hospital of North Norway
Coronary Artery Disease, Atherosclerosis
Sequential Coronary CT-angiography and Biomarkers
Currently, cardiac computed tomography angiography (CCTA) is a well-implemented non-invasive diagnostic imaging modality in patients with stable chest pain.
- Trial name
- PARSEC-NET (NCT02394262)
- Testing
- Coronary CT-angiography, Assesment of biomarkers involved in atherothrombosis
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- Maastricht University Medical Center
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Coronary Disease, Angina, Stable
Registry of RESOLUTE-ONYX™ Zotarolimus-eluting Stent Utilization in Percutaneous Small Vessel Coronary Interventionism.
DESIGN: Prospective, single-arm, multicenter, observational, prospective registry of the use of the RESOLUTE-ONYX™ zotarolimus-eluting stent in percutaneous coronary intervention in small vessels.
- Conditions
- Coronary Disease, Angina, Stable, Ischemia, Acute Coronary Syndrome
- Trial name
- Disco-9 (NCT04785846)
- Testing
- Percutaneous Coronary Intervention
- Where
- 15 sites in Spain
- Volunteers
- 307 people
- Sponsor
- Fundación Investigación Sanitaria en León
Recent Myocardial Infarction, Ventricular Dysfunction
CArdiosphere-Derived aUtologous Stem CElls to Reverse ventricUlar dySfunction
The purpose of this study is to determine whether giving cardiosphere-derived stem cells (CDCs) to patients with decreased heart function and/or a large amount of damaged muscle after a heart attack is safe.
- Trial name
- CADUCEUS (NCT00893360)
- Testing
- Autologous stem cell infusion
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Cedars-Sinai Medical Center
Coronary Disease
Evaluation of Plasma Non-coding RNAs as Biomarkers in Coronary Heart Disease
The purpose of this study is to determine whether the expression level of miR-320a are effective as biomarker in evaluating the diagnosis, prognosis and treatment effects of coronary heart disease.
- Trial name
- NCT02751060
- Testing
- No intervention
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Tongji Hospital
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in STEMI and MVD (OPTION-STEMI)
Patients with STEMI (ST-segment elevation myocardial infarction) with multivessel disease which have PCI (percutaneous coronary intervention)-suitable non-IRA (infarct related artery) will be randomized to immediate complete…
- Trial name
- NCT04626882
- Testing
- Staged in-hospital or Immediate complete revascularization
- Where
- 14 sites in South Korea
- Volunteers
- 994 people
- Sponsor
- Chonnam National University Hospital
Coronary Artery Disease, Coronary Artery Stenosis
Computed Tomographic Angiography or Conventional Coronary Angiography in Clinical Decision Making
Patients planned for elective conventional coronary angiography will undergo CT coronary angiography (Dual Source CT) in order to assess the correlation of stenosis detection and therapeutic advice between conventional and CT…
- Trial name
- CARDUCCI (NCT00566059)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease (CAD), Ischemic Heart Disease
CAPTURER PMCF Study ( rEPIC04D )
Multicenter, prospective, non-randomized, post-market clinical follow-up (PMCF) study to confirm and support the clinical safety and performance of CAPTURER to meet EU Medical Device regulation (MDR) requirements in all the…
- Trial name
- rEPIC04D (NCT05292079)
- Testing
- CAPTURER
- Where
- 5 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Fundación EPIC
Complex Regional Pain Syndromes
Investigation of the Efficacy of Transcranial Magnetic Stimulation in Patients Developing Complex Regional Pain Syndrome Type 1 in the Upper Extremity During the Subacute-Chronic Period After Ischemic Stroke
The aim of our study is to investigate transcranial magnetic stimulation (TMS) as a treatment option in Complex Regional Pain Syndrome, disseminate it to a broader patient population, and simultaneously demonstrate its…
- Trial name
- NCT06215079
- Testing
- The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK), conventional rehabilitation program
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Ischemic Stroke
The Effects of Disease Management Programs for Prevention of Recurrent Ischemic Stroke
It has been reported that stroke is the first cause of becoming bedridden, and its cumulative recurrence rate in 5 years is approximately 35%.
- Trial name
- NCT02121327
- Testing
- disease management, usual care
- Where
- Japan
- Volunteers
- 321 people
- Sponsor
- Hiroshima University
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up
An extension of the CORDMILK trial, the CORDMILK follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were non-vigorous at birth and received umbilical cord milking…
- Trial name
- CORDMILK-FU (NCT03682042)
- Testing
- Umbilical Cord Milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Myocardial Infarction
Telerehabilitation in Coronary Heart Disease
Cardiovascular diseases are the main cause of death worldwide. Aerobic fitness is related to long-term survival and a reduction in mortality and recurrent nonfatal myocardial infarction in subjects with cardiovascular disease.
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Myocardial Infarction, Percutaneous Transluminal Cutting Balloon Angioplasty of Popliteal Vein Using Fluoroscopic Guidance
- Trial name
- TRiCH (NCT02047942)
- Testing
- Center-based cardiac rehabilitation, Home-based training with telemonitoring guidance
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
ST Elevation Myocardial Infarction, Cardiovascular Diseases
RUral dispaRities in prehospitAL STEMI
Rural Americans are more likely to be unhealthy, older, living in poverty, uninsured, and medically underserved. The CDC has made achieving health equity and improving cardiovascular health for rural Americans one of their…
- Trial name
- NCT04381260
- Testing
- No intervention, Interview, Survey
- Where
- United States
- Volunteers
- 473 people
- Sponsor
- Wake Forest University Health Sciences
Cancer, Coronary Artery Disease
Calibration of MR and PET-MR Imaging Protocols at RIC
This is a protocol to facilitate on-site calibration of the technical aspects of the Siemens Biograph mMR (molecular MR) Positron Emission Tomography-Magnetic Resonance (PET-MR) scanner and the 3T Siemens Vida MR scanner at the…
- Trial name
- NCT02249520
- Testing
- PET-MR imaging on Biograph mMR scanner, MR-only imaging on Biograph mMR scanner, MR imaging on the Siemens Vida 3T MR scanner
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Coronary Artery Disease
A Comparison of Optical Coherence Tomography Guidance and Angiography-only Guidance for Percutaneous Coronary Intervention With Bioresorbable Vascular Scaffold
It is well-known that non-optimal stent implantation associated with under-expansion or incomplete strut apposition during percutaneous coronary intervention (PCI) leads to a higher incidence of restenosis and stent thrombosis.
- Trial name
- NCT02466282
- Testing
- Angiography-guided PCI with bioresorbable vascular scaffold, optical coherence tomography-guided PCI with bioresorbable vascular scaffold
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Yonsei University
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