Clinical trials: Ischemic Disease
ST Segment Elevation Myocardial Infarction, Left Ventricular Thrombus
Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant
Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events.
- Trial name
- EARLYmyo-LVT (NCT03764241)
- Testing
- Rivaroxaban, Vitamin K Antagonist
- Where
- China
- Volunteers
- 280 people
- Sponsor
- RenJi Hospital
Coronary Artery Disease, Elderly (Aged >70)
Development and Validation of a cCTA and Biomarker Based Risk Model for Coronary Revascularization in Elderly Patients With Coronary Artery Disease
This study is a prospective multi-center observational cohort involving elderly patients (≥70 years old) with multi-vessel coronary disease identified by coronary computed tomography angiography (cCTA) and scheduled for invasive…
- Trial name
- NCT07311954
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 800 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Post Marketing Clinical Trial to Demonstrate the Performance of the MedHub AutocathFFR Device.
Patients with suspected coronary artery disease who are scheduled to undergo a coronary angiography procedure will be enrolled in the study.
- Trial name
- NCT04724057
- Testing
- AutocathFFR
- Volunteers
- 488 people
- Sponsor
- Medhub Ltd.
Frailty, Coronary Artery Disease
Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients
Frailty is a major predictor of adverse outcomes following coronary artery bypass grafting (CABG), being associated with increased postoperative complications, prolonged hospitalization, delayed functional recovery, and reduced…
- Conditions
- Frailty, Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
- Trial name
- MINIFRAGILE (NCT07742475)
- Testing
- Minimally Invasive Coronary Artery Bypass Grafting (MICS-CABG), Conventional Coronary Artery Bypass Grafting (Median Sternotomy)
- Volunteers
- 194 people
- Sponsor
- University of Sao Paulo General Hospital
ST Elevation Myocardial Infarction
Effect of DLBS1033 After Primary PCI in Patients With STE-ACS
This is a prospective, randomized, double-blind, double-dummy, and controlled clinical study over a total of 4-week therapy with DLBS1033 in the management of STE-ACS after a primary PCI.
- Trial name
- NCT02976701
- Testing
- DLBS1033, Standard therapy
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Dexa Medica Group
Coronary Artery Disease
Comparison of Scoring Balloon and Conventional Balloon Predilation Before Drug Coated Balloon for de Novo Lesion in Patients With High Bleeding Risk
This study is designed to investigate whether scoring balloon (non-slip element, NSE) predilation compared to non-compliant (NC) balloon predilation for de novo lesion in patients with high bleeding risk and planning to receive…
- Trial name
- PREPARE-NSE (NCT03817801)
- Testing
- NSE balloon, NC balloon
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes
ESCALATE will provide a thorough investigation of how anti-inflammatory therapy, with low-dose colchicine, affects patients with stable coronary artery disease.
- Trial name
- ESCALATE (NCT06469528)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Atherosclerosis, Cardiovascular Diseases
Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study
To evaluate the relation of retinal microvascular characteristics to subclinical cardiovascular disease, clinical disease, and their risk factors in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease
- Trial name
- MESA-Eye (NCT00041444)
- Volunteers
- 6,176 people
- Sponsor
- University of Wisconsin, Madison
Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
The ROAMM-EHR Study
In recent years, mobile health (mHealth) apps have promised improved monitoring of health conditions to improve clinical outcomes.
- Trial name
- ROAMM-EHR (NCT06263322)
- Testing
- Actionable remotely generated health data, Non-Actionable remotely generated health data
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Coronary Artery Disease
Scoring-Balloon Angioplasty and Sirolimus-Eluting Balloon Angioplasty for the Treatment of Diffuse, Small Vessel Coronary Artery Disease (SCA-DEB Study)
This is a prospective, single-center, single-arm study to evaluate the feasibility and safety of the combination of Scoring-Balloon Angioplasty and Sirolimus-Eluting Balloon Angioplasty for the treatment of diffuse, small vessel…
- Trial name
- SCA-DEB (NCT06197022)
- Testing
- Mozec™ SEB Sirolimus Eluting Rx PTCA Balloon Dilatation Catheter
- Where
- Bulgaria
- Volunteers
- 106 people
- Sponsor
- University National Heart Hospital
Coronary Artery Disease, CT
Coronary Computed Tomography Angiography (CCTA) for the Pre-procedural Planning of Percutaneous Coronary Intervention
The CT-PLAN PCI trial will evaluate whether CCTA-guided PCI improves procedural efficiency compared with routine PCI (without pre-procedural CCTA-guidance for PCI planning) using procedural time as the primary endpoint.
- Trial name
- CT-PLAN-PCI (NCT07691502)
- Testing
- CT-guided PCI, Routine PCI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Minneapolis Heart Institute Foundation
To Assess the Presence of Internal Pudendal Artery Disease in Patients With Erectile Dysfunction Undergoing Coronary Angiography
Prevalence Of Internal Pudendal Artery Disease In Patients With Erectile Dysfunction Undergoing Diagnostic Coronary Angiography
Subjects in this study have recently had or are scheduled for a coronary angiography as part of their normal, routine medical care. This procedure uses x-ray imaging to see the inside of the heart's blood vessels.
- Trial name
- NCT01276145
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Ischemic Heart Disease
Registry in Korea: BioMimeTM Stent, Ultimaster® Stent vs. Xience® Stent
Comparison of safety and long-term effects of BioMimeTM stent and Ultimaster® stent with Xience® stent
- Trial name
- SMARTDESK-MX (NCT02986295)
- Testing
- BioMimeTM Stent, Ultimaster® Stent
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Hyeon-Cheol Gwon
Stroke, Acute Ischemic, Medium Vessel Occlusion
INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of IMP-ACT. Acute ischemic stroke (AIS) caused by intracranial arterial occlusion remains a major cause of disability and…
- Trial name
- IMP-ACT (NCT07906275)
- Testing
- Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre
- Where
- 4 sites in Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Coronary Artery Disease
CYPHERTM Stent Post-Marketing Surveillance Registry (US-PMS)
The purpose of this PMS registry, named e-CYPHER Stent Registry, is to collect post marketing surveillance data on the CYPHERTM Sirolimus-eluting Coronary Stent following marketing approval, when used in normal clinical practice…
- Trial name
- NCT00245401
- Testing
- CYPHERTM Sirolimus-Eluting Coronary Stent
- Volunteers
- 2,070 people
- Sponsor
- Cordis US Corp.
Cardiovascular Diseases, Coronary Artery Disease
Senescence in Myocardial Infarction
The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Aging, Atherosclerosis
- Trial name
- SMI (NCT07693712)
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Healthy
Primary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.
It has been suggested that a low dietary intake of antioxidant vitamins and minerals increases the incidence rate of cardiovascular disease and cancer.
- Trial name
- NCT00272428
- Testing
- ascorbic acid, vitamin E, beta carotene, selenium, zinc
- Where
- France
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute STEMI, PPCI
On vs Off-hour PPCI in STEMI Patients
ST-elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality globally, and timely reperfusion with primary percutaneous coronary intervention (PPCI) is the gold-standard treatment1.
- Conditions
- Acute STEMI, PPCI, Observational Study, Coronary Artery Disease (CAD)
- Trial name
- On vs Off PPCI (NCT07860086)
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- Assiut University
Myocardial Oxygenation Imbalance, Myocardial Infarction
Clinical Presentation and Outcomes in Patients at Risk of Type II Myocardial InfarctioN in the emerGency Department.
Type 2 myocardial infarction has been reported in the Universal Definition of Myocardial Infarction for more than 10 years and most studies resulted in a high mortality rate.
- Trial name
- COMING (NCT03953651)
- Testing
- Follow-up
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis
Ischemic Preconditioning, Exercise Tolerance and Multiple Sclerosis
Regular physical activity improves aspects such as physical fitness, fatigue, quality of life, gait and also reduces the rate of progression of disability in individuals with Multiple Sclerosis.
- Trial name
- NCT03153553
- Testing
- Ischemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
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