Clinical trials: Ischemic Lesions
Cardiogenic Shock, Acute Myocardial Infarction
Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock
The study compares the therapies of instant multivessel balloon angioplasty plus stent implantation or the balloon angioplasty plus stent implantation of the infarct artery alone with any possible graduated later treatment of the…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Complications
- Trial name
- CULPRIT-SHOCK (NCT01927549)
- Testing
- Immediate multivessel PCI, Culprit Lesion only PCI
- Where
- 3 sites in Germany
- Volunteers
- 706 people
- Sponsor
- University of Luebeck
Acute Ischemic Stroke Patients
Evaluation of rSO2 Between Frontal Lesion Area and Normal Area of Brain by NIRSITX Using NIRS in Acute Ischemic Stroke Patients.
The clinical trial is for acute ischemic stroke patients measuring cerebral oxygen saturation (rSO2) values using pulse oximeter of near-infrared spectroscopy in the frontal lesion area and normal area of brain.
- Trial name
- fNIRS (NCT06250608)
- Testing
- Pulse oximeter, NIRSITX
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- OBELAB, Inc.
Calcified Coronary Lesions, ST Elevated Myocardial Infarction
European Registry On Plaque ModifiCAtion in the STEMI Population (ROCA-STEMI)
This is an European prospective cohort study from February 2023 until February 2024. The investigators want to analyze the clinical success, efficacy and safety of consecutive patients who presented with ST-elevation myocardial…
- Conditions
- Calcified Coronary Lesions, ST Elevated Myocardial Infarction, Plaque Modification Technique
- Trial name
- ROCA-STEMI (NCT05752617)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital del Mar
Coronary Artery Disease
Clinical Outcomes of Patients With Deferred Revascularization Based on FFR and iFR Negative Coronary Artery Lesions.
The objective is to assess long-term clinical outcomes of patients in whom intervention of coronary lesions was deferred due to negative fractional flow reserve (FFR) and negative Instantaneous wave-free ratio (iFR) in a…
- Trial name
- NCT05240768
- Testing
- Fractional flow reserve, instantaneous wave-free Ratio
- Where
- Pakistan
- Volunteers
- 345 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Coronary Artery Disease
Acrobat Coronary Stent System Effectiveness European Study
The purpose of this randomized controlled trial (RCT) is to demonstrate the clinical benefit and impact on resource utilization of percutaneous coronary interventions (PCI) with the Svelte Acrobat Stent System compared to any…
- Trial name
- ACES (NCT01761591)
- Testing
- PCI with Svelte Acrobat, PCI with other BMS
- Where
- 12 sites in Belgium, France and 1 more
- Volunteers
- 300 people
- Sponsor
- Svelte Medical Systems Europe
Coronary Artery Disease
Double Rewire Versus Double Kissing Crush Stenting Technique in Left Main Bifurcation Lesions
The DR vs DK trial is designed to elucidate the benefits of Double Rewire crush technique (DR-Crush) over Double Kissing Crush (DK-Crush) technique in patients with Unprotected Left Main Bifurcation lesions (ULMb).
- Trial name
- DR vs DK crush (NCT05258318)
- Testing
- DK crush, DR crush
- Sponsor
- Fundación EPIC
Coronary Artery Stenosis
Study of BioNIR Drug Eluting Stent System in Coronary Stenosis
The BioNIR study aims to show that the BioNIR ridaforolimus eluting stent is non-inferior to the Resolute zotarolimus-eluting stent for the primary clinical endpoint of target lesion failure (TLF) at 12 months; that it is…
- Trial name
- BIONICS (NCT01995487)
- Testing
- BioNIR, Resolute
- Where
- 8 sites in United States, Belgium and 6 more
- Volunteers
- 1,919 people
- Sponsor
- Medinol Ltd.
Coronary Stenosis, Drug-coated Balloon
DCB Angioplasty for Coronary Lesions: an OCT Analysis
In this study, the investigators preformed OCT before and after DCB treatment, as well as at 6 months of follow-up, to assess the tissue characterization.
- Trial name
- NCT04984135
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Coronary Artery Disease
Pre-procedural 3DCT Versus Angiography Guided PCI for Ostial Right Coronary Artery Lesions
Even with second generation drug eluting stents, rates of target lesion failure (TLF) for aorto-ostial RCA lesions remain high [3yrs TLF 14.2%].
- Trial name
- 3DCT-RCA (NCT05172323)
- Testing
- 3DCT-scan, Angiography guided PCI
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Ziekenhuis Oost-Limburg
Coronary Artery Disease
Post-marketing Registry of Inspiron Sirolimus Eluting Coronary Stent
Post-marketing, prospective, multicentric, non-randomized registry to evaluate the safety and efficacy of Inspiron Sirolimus Eluting Coronary Stent at the treatment of "real-world" patients.
- Trial name
- Inspiron RL II (NCT03263260)
- Testing
- implant
- Where
- Brazil
- Volunteers
- 2,504 people
- Sponsor
- Scitech Produtos Medicos SA
Stable Angina Pectoris, Unstable Angina Pectoris
PCB for Long De Novo Lesions of Main Coronary Arteries (D-Lesion Long Trial)
This study evaluates the Efficacy and Safety of Paclitaxel-Coated Balloon Catheter in Patients With Diffuse Long De Novo Lesions of Main Coronary Arteries.
- Trial name
- NCT03155971
- Testing
- Paclitaxel-Coated Balloon
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The People's Hospital of Liaoning Province
Coronary Artery Disease, Cardiovascular Risk Factors
Optimization of Interval Exercise Based-intensity on Ventilatory Anaerobic Threshold in Coronary Artery Disease
The purpose of this study is to investigate the effects of interval training, based-intensity on 70% at 110% of oxygen consumption and workload attained on ventilatory anaerobic threshold, on aerobic functional capacity…
- Trial name
- NCT02313831
- Testing
- Interval training
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Universidade Federal de Sao Carlos
Fibrillation, Atrial, Coronary Artery Disease
Atrial Fibrillation and Non-obstructive Coronary Lesions
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy.
- Conditions
- Fibrillation, Atrial, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- AF-CAD (NCT04537507)
- Testing
- Coronary angiography
- Where
- 5 sites in Poland, Russia and 1 more
- Volunteers
- 8,000 people
- Sponsor
- Medical University of Bialystok
Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO)
Clinical Outcomes of Drug-Coated Balloons in the Treatment of Patients With Coronary De Novo Chronic Total Occlusion Lesions
The aim of this study is to evaluate the long-term efficacy and safety of drug-coated balloon (DCB) strategies, including DCB alone or hybrid strategies of DCB and drug-eluting stent (DES), compared to DES-only in patients with…
- Conditions
- Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO), Coronary Artery Disease (CAD)
- Trial name
- DCB-CTO (NCT07463664)
- Testing
- DES Implantation, DCB Angioplasty
- Where
- 18 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
ST-elevation Myocardial Infarction, Multi Vessel Disease
Primary PCI in Patients With ST-elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization
In patients with ST-elevation myocardial infarction (STEMI) the primary treatment is acute angioplasty of the acute occlusion (culprit lesion).
- Trial name
- PRIMULTI (NCT01960933)
- Testing
- Percutaneous coronary intervention, FFR
- Where
- 2 sites in Denmark
- Volunteers
- 650 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease
Efficacy of Xience/Promus Versus Cypher in rEducing Late Loss After stENTing
Objectives 1. To evaluate the safety and long-term effectiveness of coronary stenting with the Everolimus-eluting coronary stent system(EECSS) (XIENCETM V, Abbott Vascular, Santa Clara, CA, PromusTM, Boston Scientific, Natick…
- Trial name
- EXCELLENT (NCT00698607)
- Testing
- Everolimus-eluting stent (Xience or Promus), Sirolimus-eluting stent (Cypher), 6-month clopidogrel therapy
- Where
- South Korea
- Volunteers
- 1,466 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-IV: (LONG-DES-IV)
This randomized study is a multi-center, randomized, study to compare the efficacy of sirolimus (Cypher) versus zotarolimus-eluting stent (Endeavor Resolute) implantation for long coronary lesions.
- Trial name
- LONG-DES-IV (NCT01186094)
- Testing
- Cypher, Endeavor Resolute
- Where
- 12 sites in South Korea
- Volunteers
- 502 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease
Elixir Medical Clinical Evaluation of the Novolimus-Eluting Coronary Stent System: A Randomized Study "EXCELLA II STUDY"
Randomized Study To evaluate the safety and effectiveness of the Elixir Medical DESyne Novolimus-Eluting Coronary Stent System with Durable Polymer through the assessment of clinical, angiographic and IVUS endpoints as compared…
- Trial name
- NCT00792753
- Testing
- Medtronic Endeavor Coronary Stent System, DESyne BD Novolimus Stent System, DESyne Novolimus Stent System
- Where
- 8 sites in Australia, Belgium and 6 more
- Volunteers
- 360 people
- Sponsor
- Elixir Medical Corporation
Coronary Artery Disease
Intravascular Ultrasound Prediction of Myocardial Size and Coronary Computed Tomography-Derived Ischemic Burden for Coronary Lesion
The aims of this study are 1) to identify IVUS determinants of the CAMS-derived myocardial territories subtended to the diseased vessels, 2) to find IVUS determinant for the extent of CAMS-derived myocardial size, and 3) to…
- Trial name
- IVUS-CAMS (NCT02845505)
- Testing
- Intravascular Ultrasound, coronary computed tomography angiography
- Where
- 12 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
Drug-Coated Balloon in Patients With High Bleeding Risk
DCB-HBR trial is prospective, multi-center, open-label, randomized controlled, noninferiority trial. The aim of the study is to compare clinical outcomes of drug-coated balloon (DCB) with drug-eluting stent (DES) for treatment of…
- Trial name
- DCB-HBR (NCT05221931)
- Testing
- Percutaneous coronary intervention
- Where
- 17 sites in South Korea
- Volunteers
- 1,359 people
- Sponsor
- Samsung Medical Center