Clinical trials: Ischemic Postconditioning
Ischemic Stroke
Impact of Remote Ischemic Postconditioning on Autonomic Function in Stroke Patients
The purpose of this study is to determine whether remote ischemic postconditioning (RIPostC) initiates autonomic nervous system response and affects the prognosis in patients with acute ischemic stroke.
- Trial name
- IRAS (NCT02777099)
- Testing
- remote ischemic postconditioning
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Acute Ischemic Stroke, Large Vessel Occlusion
Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke
Post-ischemic adaptation is a physical brain protective treatment strategy in which an ischemic event in an organ or tissue is treated and blood flow is restored, and an ischemic stimulus is given to local tissues to induce the…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Intracranial Artery Occlusion With Cerebral Infarction, Endovascular Treatments
- Trial name
- NCT06456437
- Testing
- Post-conditioning Balloon dilation and contraction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ming Wei
Stroke, Acute, Neuroprotection
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
The goal of this clinical trial is to determine if direct ischemic post-conditioning (IPostC) can alleviate ischemic-reperfusion injury (I/R) in patients who have undergone endovascular thrombectomy (EVT).
- Conditions
- Stroke, Acute, Neuroprotection, Ischemic Conditioning
- Trial name
- NCT06545734
- Testing
- Direct Ischemic Post-conditioning, Endovascular therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke, Endovascular Treatment
Endovascular Treatment and RIPC in Acute Ischemic Stroke
Endovascular treatment（ET）is an effective therapy for acute ischemic stroke(AIS) with great vessel obstruction. However, acute complications such as high postoperative perfusion injury, hemorrhagic transformation and restenosis…
- Trial name
- EnTRIPS (NCT04581759)
- Testing
- RIPC device (IPC-906X), foundational treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Ischemic Stroke
Long-term Outcome of RIPC After IV Thrombolysis in AIS Patients
The goal of this observational study is to learn about the long-term efficacy of our previous study in acute ischemic stroke(AIS) patients who underwent either remote ischemic postconditioning(RIPC) or sham treatment after…
- Trial name
- RESPONTH (NCT05614401)
- Testing
- functional and medical information
- Where
- China
- Volunteers
- 62 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ischemic Stroke
Oriental Research AlliaNce of Acute Ischemic Stroke Given Endovascular Treatment
To determine the safety and efficacy of in situ ischemic postconditioning immediately after successful reperfusion in AIS patients underwnet EVT.
- Trial name
- ORANGE (NCT05024292)
- Testing
- rapid local ischemic postconditioning (RL-IPostC)
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Ischemic Stroke, Mechanical Thrombectomy
Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke
The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical…
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVE (NCT06307743)
- Testing
- rapid local ischemic postconditioning
- Volunteers
- 135 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
ST Elevation Myocardial Infarction
STEMI Treatment Optimization by Ischemic Postconditioning and IVUS Guidance
The purpose of is study is to investigate whether ischemic postconditioning (iPOST) and intravascular ultrasound-guided (IVUS) percutaneous coronary intervention (PCI) improve the clinical outcome of patients with ST-segment…
- Trial name
- DANAMI4 (NCT04775914)
- Testing
- PCI + Ischemic conditioning, Stent with ultrasound
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Thomas Engstrom
ST Segment Elevation Myocardial Infarction
Ischemic Postconditioning in STEMI Patients Treated With Primary PCI
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI…
- Trial name
- iPOST2 (NCT03787745)
- Testing
- Ischemic postconditioning, Conventional
- Where
- Denmark
- Volunteers
- 1,800 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stroke
Effects of Limb Ischemic Postconditioning in Young sICAS
The purpose of this study is to evaluate the protective effects of upper limb ischemic postconditioning on collateral circulationin young symptomatic intracranial atherosclerosis and the baseline characteristics of trial…
- Trial name
- EPIC-sICAS (NCT02323425)
- Testing
- Remote ischemic postconditioning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xi'an Jiaotong University
Stroke, Acute
r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
to detect the efficiency and safety of intravenous rtPA combined with RIPC in acute ischemic stroke patients
- Trial name
- rtPA-RIC (NCT02886390)
- Testing
- ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Myocardial Infarction
Pharmacological Postconditioning to Reduce Infarct Size Following Primary PCI
Both pre- and postconditioning seem to protect cardiomyocytes during reperfusion therapy. Investigations both ex vivo and in vivo suggest that a gut derived hormone, Glucagon-Like-Peptide-1 (GLP-1), is able to reduce…
- Trial name
- POSTCON II (NCT00835848)
- Testing
- Exenatide, Saline
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney
The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
- Conditions
- Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney, Remote Ischemic Postconditioning
- Trial name
- NCT01637038
- Testing
- RIPC
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Hepatectomy
Organ Protection With Sevoflurane Postconditioning
Organ protection, volatile anesthetics, postconditioning, hepatic surgery
- Trial name
- NCT00518908
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- 125 people
- Sponsor
- University of Zurich
Myocardial Reperfusion Injury
Post Cond No Reflow
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of…
- Trial name
- NCT01208727
- Testing
- postconditioning
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Hospices Civils de Lyon
Myocardial Reperfusion, Myocardial Infarction
Effects of Postconditioning On Myocardial Reperfusion
The purpose of this study is to investigate the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction.
- Trial name
- POST (NCT00942500)
- Testing
- Post-conditioning
- Where
- South Korea
- Volunteers
- 700 people
- Sponsor
- Samsung Medical Center
Acute Ischemic Stroke, Cerebral Embolism and Thrombosis
Thrombolysis and RIPC in Acute Ischemic Stroke
Remote ischemic postconditioning (RIPC) is suggested to protect the cerebral cell against ischemia in various settings. However, the effect of RIPC in patients with acute ischemic stroke who undergo thrombolysis has yet to be…
- Trial name
- tripcais (NCT03218293)
- Testing
- RIPC device (IPC-906X)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
ST Elevation Myocardial Infarction, Ventricular Remodeling
Impact of Ischemic Post-conditioning
Study will investigate \& compare the left ventricular remodeling \& systolic function between two groups of ST-elevation myocardial infarction undergoing primary per-cutaneous coronary intervention applying ischemic…
- Conditions
- ST Elevation Myocardial Infarction, Ventricular Remodeling, Ventricular Dysfunction, Ischemic Reperfusion Injury
- Trial name
- NCT04068116
- Testing
- Primary per-cutaneous coronary intervention
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Ischemic Stroke, Mechanical Thrombectomy
Local Ischemic Postconditioning in Acute Ischemic Stroke
This study aims to determine the safety and optimal dose of rapid local ischemic postconditioning in acute ischemic stroke(AIS) patients received successful thrombectomy reperfusion.
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVEI (NCT06526429)
- Testing
- rapid local ischemic postconditioning
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital