Clinical trials: Islet Transplantation
Pancreatic Islet Quality Control
Quality Control of Pancreatic Islet Intended to Islet Graft Cells Intended to Stabilot Islet Graft Protocol
Islet quality control after pancreatic islets isolation process is insufficient. The Islet Chip study proposes to develop a bio-sensor that will allow a multi-parametric analysis of islet graft based on measurement of islet…
- Trial name
- ISLET CHIP (NCT03067324)
- Where
- 8 sites in France, Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Islet Transplantation in Diabetes Mellitus Type 1
Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation
The objective of this clinical trial was: to assess whether Reparixin leads to improved transplant outcome as measured by glycaemic control following intra-hepatic infusion of pancreatic islets in patients with Type 1 diabetes…
- Trial name
- REP0211 (NCT01817959)
- Testing
- Reparixin
- Where
- 9 sites in United States, Czechia and 3 more
- Volunteers
- 51 people
- Sponsor
- Dompé Farmaceutici S.p.A
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum
Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula
Curative management of locally resectable invasive adenocarcinomas located in the cephalic region of the pancreas (pancreas, duodenum and ampulla of Vater) requires a pancreaticoduodenectomy followed by adjuvant chemotherapy.
- Conditions
- Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum, Ampullary Adenocarcinoma
- Trial name
- TPIAT-01 (NCT05116072)
- Testing
- total pancreatectomy, intraportal islet autotransplantation
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Benign Pancreatic Neoplasm, Chronic Pancreatitis
A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors
This phase I/II trial assesses the safety and effectiveness of total pancreatectomy with islet cell autotransplantation for the treatment of patients with long-term pancreatic inflammation (chronic pancreatitis) and non-cancerous…
- Conditions
- Benign Pancreatic Neoplasm, Chronic Pancreatitis, Recurrent Acute Pancreatitis
- Trial name
- NCT05453851
- Testing
- Pancreatectomy, Quality-of-Life Assessment, Treatment Planning
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- OHSU Knight Cancer Institute
Chronic Pancreatitis, Mesenchymal Stem Cells
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT
This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT).
- Trial name
- NCT05095532
- Testing
- Bone marrow-derived mesenchymal stem cells
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Diabetes Mellitus, Type 1
Safety and Efficacy of PEG-Encapsulated Islet Allografts Implanted in Type I Diabetic Recipients
Insulin dependent Type I diabetics require daily insulin therapy to normalize blood glucose but may have difficulty with significant glycemic excursions and hypoglycemic episodes and crises.
- Trial name
- NCT00260234
- Testing
- Allogeneic Cultured Islet Cells (human); Encapsulated
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Novocell
Diabetes Mellitus, Insulin-Dependent
Islet Transplantation for Type 1 Diabetes
The purpose of this study is to test whether the islet cell transplantation procedures and results from a previous study in Edmonton, Canada, can be repeated.
- Trial name
- NCT00014911
- Testing
- Islet Transplantation, Sirolimus, Tacrolimus
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 36 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes Mellitus
Screening of Subjects With Type I Diabetes to Determine Eligibility for Islet Transplantation
Protocol to screen potential subjects for islet transplantation
- Trial name
- NCT02004964
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rodolfo Alejandro
Diabetes Mellitus, Type I
Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00789308
- Testing
- Low Molecular Weight Sulfated Dextran (LMW-SD), Heparin, CellCept® (Mycophenolate mofetil) OR Rapamune® (Sirolimus)
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1
Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00434850
- Testing
- Allogeneic Pancreatic Islet Cells, Deoxyspergualin, Antithymocyte globulin
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Islet Transplantation
Nephrologic Prognosis 10 Years After Diabetes Cell Therapy
Islet transplantation for type 1 diabetes results are still improving, and actually Insulin-independence with normal HbA1c is obtained in 50% of patients after 5 years, 80% of c-peptide positive patients.
- Trial name
- PRONOCELDIAB (NCT02627690)
- Testing
- islet transplanted, non islet transplanted
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Lille
Type 1 Diabetes
Bone Marrow vs Liver as Site for Islet Transplantation
The goal of this study is to evaluate safety and efficacy of bone marrow (BM) as site for pancreatic islet transplantationin humans.
- Trial name
- IsletBOM2 (NCT01722682)
- Testing
- Human pancreatic islet transplantation
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Ospedale San Raffaele
Type 1 Diabetes Mellitus
Islet After Kidney Transplant for Type 1 Diabetes
The purpose of this study is to determine if prolonged administration of the anti TNF (tumor necrosis factor)-Alpha agent etanercept is associated with enhanced graft survival in patients undergoing islet after kidney…
- Trial name
- NCT00784966
- Testing
- etanercept
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Type 1 Diabetes Mellitus
Heparinized Islets in Clinical Islet Transplantation
In this study the islets will be surface modified to carry immobilised heparin (Corline Heparin Conjugate) prior to transplantation.
- Trial name
- NCT00678990
- Testing
- Transplantation of islets with heparin coating
- Where
- 2 sites in Sweden
- Volunteers
- 10 people
- Sponsor
- Corline Biomedical AB
Type 1 Diabetes Mellitus
Aralast NP in Islet Transplant
Islet transplantation is a relatively new procedure used in people with difficult to control Type 1 diabetes. Insulin producing cells (islets) are isolated from a pancreas donated by the next of kin of a person who is brain dead.
- Trial name
- NCT02520076
- Testing
- Alpha-1 Antitrypsin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Islet Cell Transplantation, Type 1 Diabetes
Pancreatic Islet Cell Transplantation - A Novel Approach to Improve Islet Quality and Engraftment
The purpose of this study is to assess a novel approach to immunosuppression in allogenic pancreatic islet cell transplant recipients.
- Trial name
- NCT00530686
- Testing
- Islet cell transplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor Research Institute
Diabetes type1
cePolyTregs in Islet Transplantation
The transplant of the insulin-producing cell into the liver (Islet transplant) has been proven an effective and valuable treatment for type 1 diabetics patients with poor blood sugar.
- Trial name
- cePolyTregs (NCT05349591)
- Testing
- cePolytreg
- Where
- Canada
- Sponsor
- University of Alberta
Diabetes Mellitus Type 1
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression
This study will test whether a new islet transplant procedure will enable patients with type 1 diabetes mellitus to stop insulin therapy. Islets are cell clusters in the pancreas that contain insulin-producing cells.
- Trial name
- NCT00006505
- Testing
- Islet Transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes, End Stage Renal Disease
Intraportal or Intramuscular Site for Islets in Simultaneous Islet and Kidney Transplantation
Islet transplantation is a promising treatment of type 1 diabetes in selected cases. Results are however hampered by a relatively low number of islets surviving the transplantation into the liver, which currently is the site for…
- Trial name
- NCT01967186
- Testing
- Intraportal islet transplantation, Intramuscular islet transplantation, Intramuscular transpl with stemcells
- Volunteers
- 36 people
- Sponsor
- The Nordic Network For Clinical Islet Transplantation
Type 1 Diabetes, Postpancreatectomy Hyperglycemia
Bone Marrow as an Alternative Site for Islet Transplantation
The goal of this study is to evaluate safety and feasibility of bone marrow (BM) as site for islet transplantation (Tx) in humans.
- Trial name
- NCT01345227
- Testing
- Intra bone marrow islet infusion
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Ospedale San Raffaele