Clinical trials: Isolation
Sleep, Physical Activity
Determining How Indoor Lighting Affects the Brain Health of Older Adults
The goal of this randomized, cross-over, single-site trial followed by an exploratory third intervention is to understand how indoor lighting affects different measures of brain health in older adults living in independent living…
- Conditions
- Sleep, Physical Activity, Cognitive Function, Social Isolation
- Trial name
- NCT05978934
- Testing
- Static Lighting Condition (L1), Dynamic Lighting Condition (L2), Dynamic Lighting Condition (L3)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Well Living Lab, Inc.
Gingival Health
Effect of Retentive Rubber-Dam Clamps
This study aims to evaluate the effect of retention rubber dam clamps used on premolar teeth during rubber dam isolation on gingival health.
- Trial name
- NCT06611735
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Marmara University
Nutrition Poor, Physical Inactivity
Digital Nutrition Intervention for Older Adults
The "digital divide" or gap in technological access and knowledge, for older adults has worsened during the COVID-19 pandemic, leading to disruptions in services like congregate meal programs funded by the Older Americans Act.
- Conditions
- Nutrition Poor, Physical Inactivity, Social Isolation
- Trial name
- NCT05220631
- Testing
- Technology intervention, Digital Nutrition Intervention
- Where
- United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- The University of Texas at San Antonio
Social Isolation, Loneliness
The CONNECT Program: Testing a Telephone-Based Mental Health Intervention for Older Adults
This study will test a telephone-based group intervention called "The CONNECT Program" which is designed for adults aged 65+ who are currently experiencing social isolation or loneliness, and symptoms of anxiety or depression.
- Conditions
- Social Isolation, Loneliness, Depression, Anxiety
- Trial name
- CONNECT (NCT05120765)
- Testing
- The CONNECT Program
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba
Loneliness, Social Isolation
Telephone Calls for Health for Homebound Older Adults
A randomized controlled trial of the effect of 4 weeks of regular check-in calls, up to 5 per week based on participant's choice and 2 survey collection calls and possible referral of other services, versus no daily check-in…
- Conditions
- Loneliness, Social Isolation, Depression
- Trial name
- NCT04595708
- Testing
- Phone Call
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Oligohydramnios
Fetal Renal Artery Doppler Indices in Borderline Isolated Oligohydramnios
The purpose of the study is to investigate third trimester fetal renal artery doppler indices in borderline idiopathic isolated oligohydramnios and relationship between neonatal outcomes.
- Trial name
- NCT02901340
- Testing
- one to two liters of water daily
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Atherosclerosis, Impaired Glucose Tolerance
The Study of Atherosclerosis With Ramipril and Rosiglitazone
The purpose of this study is to determine if ramipril and/or rosiglitazone retard the progression of atherosclerosis as evaluated by serial carotid intermedial thickness measurements.
- Conditions
- Atherosclerosis, Impaired Glucose Tolerance, Isolated Impaired Fasting Glucose, Cardiovascular Disease
- Trial name
- NCT00140647
- Testing
- Ramipril, Rosiglitazone
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gerstein, Hertzel, MD
Raynaud's Phenomenon Isolated Primary, Raynaud's Phenomenon (Secondary)
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.
The investigators seek to perform a comparative transcriptome analysis of TRP channels residing in the skin between primary and scleroderma secondary Raynaud's phenomenon and healthy subjects.
- Conditions
- Raynaud's Phenomenon Isolated Primary, Raynaud's Phenomenon (Secondary), Healthy
- Trial name
- TRP (NCT03211325)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Loneliness, Well-Being, Psychological
A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL)
The purpose of this study is to compare the efficacy of a personalized, co-designed robot interaction against a standardized, fixed robot interaction for reducing loneliness, depression, as well as improving self-agency and…
- Conditions
- Loneliness, Well-Being, Psychological, Depression - Major Depressive Disorder
- Trial name
- RoSELL (NCT07102017)
- Testing
- Co-Design LOVOT Intervention, Standard LOVOT Intervention
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
Prospective Study on the Effectiveness and Safety of Bi-polar Pulse-field Tip-catheter Ablation for Atrial Fibrillation in China（POTENTIAL-AF）
POTENTIAL-AF is a prospective, multicentre, observational registry study evaluating the real-world effectiveness and safety of bi-polar pulse-field tip-catheter ablation (PFA) for atrial fibrillation (AF) in China.
- Trial name
- POTENTIAL-AF (NCT07627685)
- Testing
- Bi-polar Pulse-field Ablation (PFA) - LEAD-PFA System with PulsedFA catheter
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Onychomycosis, Resistant Infection
Mycosis Culture Collection From Dermatological Isolated
This pilot, prospective, observational drug study aims to evaluate the efficacy, tolerability and safety of topical and oral antifungals in the treatment of onychomycosis caused by yeasts, dermatophytic moulds and…
- Conditions
- Onychomycosis, Resistant Infection, Nail Diseases
- Trial name
- MYCDERM (NCT05482763)
- Testing
- Terbinafine Topical Gel, Itraconazole 200 mg, Terbinafine 250 mg
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata
Hypertension, Isolated Systolic Hypertension (ISH)
A Single Rising Dose Study of MK-8150 (MK-8150-001)
This study will evaluate the safety and tolerability of MK-8150 and its effect on central systolic blood pressure (cSBP) and heart rate corrected augmentation index (AIx) when given as single oral doses in healthy males and in…
- Trial name
- NCT01590810
- Testing
- MK-8150 2.0 mg, MK-8150 10 mg, MK-8150 40 mg
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Isolated Gastrocnemius Tightness
Immediate Effects of Graston Massage on Muscle Properties and Performance in Elite Female Handball Players
The aim of this study is to investigate the immediate effects of Graston massage on muscle mechanical properties and sports performance in elite handball players with isolated gastrocnemius tightness.
- Trial name
- NCT06911580
- Testing
- Graston Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Giresun University
Running, Leg Injuries
Exercise Interventions, Running Biomechanics and Injury in Novice Runners
The purpose of this study is to understand the effects of muscle strengthening and balance exercise interventions on muscle strength, running mechanics and postural control in novice recreational runners.
- Trial name
- NCT01900262
- Testing
- Strengthening, Balance Training, Stretching
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Pit and Fissure Sealants, Dental Caries Prevention
Dry-Shield vs Rubber Dam During Fissure Sealant Placement
This randomized clinical trial aims to evaluate the efficiency of the Dry-Shield isolation system compared with rubber dam isolation and cotton roll isolation during fissure sealant application in permanent molars among pediatric…
- Trial name
- DRY-SEAL (NCT07622173)
- Testing
- Pit and fissure sealant (Conseal F)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Loneliness, Mood
Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation
This project will to evaluate whether a proactive social robot (ElliQ) has an impact on reducing social isolation and loneliness in older adults who are living alone, while also promoting independence and aging in place.
- Conditions
- Loneliness, Mood, Quality of Life
- Trial name
- NCT03972787
- Testing
- Proactive social robot
- Where
- 2 sites in United States, Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Baycrest
Cardiovascular Responses in Elderly With Isolated Systolic Hypertension
Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension
Aim to study the exercise responses to both static and dynamic exercise in elderly people with and without essential isolated systolic hypertension, seeking to identify potentially dangerously high responses
- Trial name
- NCT02270216
- Testing
- static hand grip exercise, cycling exercise
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sahachat Aueyingsak
Thrombocytopenia, Isolated, Stem Cell Transplant Complications
AZA Combined With NAC for PIT After HSCT
Prolonged isolated thrombocytopenia (PIT) that is refractory to conventional treatments has remained a critical complication after allogeneic hematopoietic cell transplantation since decades years ago.
- Trial name
- NCT05126004
- Testing
- Azacitidine, N Acetyl L Cysteine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Aging Well
Yoga for Seniors
The overall purpose of this study is to deliver a 12-week yoga program to older adults (over 60 years of age) in rural WI who do not have access to yoga programming and examine the effects of the programming on activities of…
- Trial name
- NCT04889131
- Testing
- Yoga Program Immediately, Wait-Listed Control, Activity Monitor
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison