Clinical trials: Isothiocyanate
Bioavailability
Bioavailability of Chemopreventive and Nutritional Compounds in Broccoli
The aim of this study was to determine the absorption of isothiocyanates (ITC) after ingestion of kailan-hybrid broccoli through the analysis of the correspondent urinary biomarkers.
- Trial name
- NCT01743924
- Testing
- raw broccoli
- Where
- Spain
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universidad Politécnica de Cartagena
Physical Performance, Glucose
Timing of Broccoli Sprout Intake to Improve Exercise Performance
This study examines how the timing of intake of a broccoli sprout-based drink (a natural source of isothiocyanates, ITCs) affects physiological responses, recovery, and performance after a standardized endurance cycling session.
- Conditions
- Physical Performance, Glucose, Glycogen Metabolism, Lactate
- Trial name
- NCT07461194
- Testing
- Broccoli sprout drink (isothiocyanate-rich
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Healthy
Acute Intervention with Sulforaphane-Smart®
The Sulforaphane-Smartt® formula is a pill, patented by the company INGREDALIA, prepared with broccoli by-products which have been concentrated and enriched in glucosinolates/isothiocyanates (GLS/ITCs).
- Trial name
- SANO-Acute (NCT06856486)
- Testing
- Sulforaphan Smart®
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mª Jesús Periago
Metabolic Disturbance
Isothiocyanates and Metabolic Health
Many sprouts, for example broccoli sprouts, contain substances that have shown to have protective effects, both against oxidative stress and against carcinogenic substances.
- Trial name
- IMH (NCT05070585)
- Testing
- Isothiocyanate rich sprouts
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Lung Cancer, Tobacco Use Disorder
Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of phenethyl isothiocyanate may prevent lung cancer in people who smoke cigarettes.
- Trial name
- NCT00691132
- Testing
- phenethyl isothiocyanate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Minnesota
Obesity and Overweight
Chronic Intervention With Sulforaphane-Smart® in Overweight and Obese Adults
The Sulforaphane-Smart® formula is a pill, patented by the company INGREDALIA, prepared with broccoli by-products which have been concentrated and enriched in glucosinolates/isothiocyanates (GLS/ITCs).
- Trial name
- SANO-Chronic (NCT06964659)
- Testing
- Sulforaphan-Smart® formula
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Mª Jesús Periago
Healthy Volunteers
Brassica Intake and Isothiocyanate Absorption
Healthy individuals (n=18) will participate in 2 controlled-feeding study periods that are 3 weeks each in length: 1) Control diet 2) Brassica diet.
- Trial name
- NCT02346812
- Testing
- Controlled diet without brassica vegetables, Controlled diet with brassica vegetables
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Prostate Cancer Prevention
Chemoprevention of Prostate Cancer, HDAC Inhibition and DNA Methylation
The objective of the study is to identify mechanisms by which compounds found in cruciferous vegetables alter gene expression via epigenetic modifications (changes in gene expression) and may prevent prostate cancer development.
- Trial name
- PBroC (NCT01265953)
- Testing
- SFN-rich broccoli sprout extract capsules, Gelatin capsule containing microcrystalline cellulose.
- Where
- 2 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Portland VA Medical Center
Leukemia, Lymphoproliferative Disorders
Study of Phenethyl Isothiocyanate in Lymphoproliferative Disorders
The goal of this clinical research study is to learn the highest tolerable dose of phenethyl isothiocyanate (PEITC) that can be given to patients who have a lymphoproliferative disorder that has been treated with fludarabine.
- Trial name
- NCT00968461
- Testing
- Phenethyl Isothiocyanate (PEITC)
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer
Phenethyl Isothiocyanate in Preventing Lung Cancer in People Who Smoke
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Phenethyl isothiocyanate may be effective in preventing lung cancer in smokers.
- Trial name
- NCT00005883
- Testing
- phenethyl isothiocyanate
- Sponsor
- NYU Langone Health
Healthy
The Conversion of ENcapsulated GlucorAphanin, Gut Microbiota Phylogeny and gEnotype Study (ENGAGE)
The variation in extent of isothiocyanate (ITC) excretion in urine from a capsule delivered dose of glucoraphanin will correlate with differences in (a) the gut microbiota, and (b) the genotype of key polymorphic genes (GSTM1…
- Trial name
- ENGAGE (NCT01927666)
- Testing
- 100mg glucoraphanin
- Where
- United Kingdom
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
PARKINSON DISEASE (Disorder), Multiple Sclerosis (MS) - Relapsing-remitting
Myrosinase Bioactivated Gglucoraphanin for the Treatment of Neurodegenerative Diseases (GRA-MYR-ND)
Glucosinolates (GLs) are phytocompounds mainly found in the Cruciferae (Brassicacea) and Moringa oleifera plants. The hydrolysis of GLs by myrosinase led to the production of isothiocyanate (ITCs).
- Conditions
- PARKINSON DISEASE (Disorder), Multiple Sclerosis (MS) - Relapsing-remitting, Pediatric Patients Affected by Neuromuscolar and Degenerative Diseases
- Trial name
- GRA-MYR-ND (NCT07360977)
- Testing
- bioactivated GRA for adult patients, bioactivated GRA for pediatric patients
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo