Clinical trials: Ivf
Infertility
Does Letrozole Improve the Outcomes and/or Reduce the Cost of IVF-ET Cycles?
This research is being done to determine whether the success rate of in vitro fertilization treatment can be improved, while lowering the cost incurred from infertility medications using a pill called letrozole.
- Trial name
- Cost-Less (NCT00804960)
- Testing
- Letrozole, Std IVF Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in High Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in high responders.
- Trial name
- NCT00963079
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Pregnancy, Ovarian
Long Antagonist Protocol for IVF With Single Luteal Dose of Degarelix
A prospective study of three different doses of Degarelix in late luteal phase of women undergoing ovarian stimulation for IVF
- Trial name
- NCT03240159
- Testing
- Degarelix
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
IVF
Higher Dose of Rekovelle in Oocyte Donors
Higher numbers of oocytes have not been shown to increase implantation or live newborn rates, but higher numbers of oocytes are likely to be beneficial in certain treatments.
- Trial name
- REKO15 (NCT04778358)
- Testing
- Follitropin Delta, Recombinant
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Cetrotide Treatment Optimization
Rationale: In daily practice fertility treatment is increasingly patient focused and innovative medication and standardized treatment guidelines are being developed to improve patient convenience.
- Trial name
- NCT00866034
- Testing
- Cetrotide (Ovarian stimulation)
- Where
- Netherlands
- Volunteers
- 617 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Infertility
A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa
Prospective open label, randomised, parallel group, comparative pilot.
- Trial name
- NCT00257556
- Testing
- Menotrophin, Follitropin alfa
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Ovarian Stimulation
Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist
Objective: To compare the efficacy of using mild ovarian stimulation protocol and conventional stimulation protocol in IVF outcome. Design: Prospective randomized trial Setting: University IVF setting.
- Trial name
- NCT00830492
- Testing
- clomiphene citrate, Ultrasound, GnRH antagonist
- Where
- Iran
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Pregnancy Complications, IVF
The START Clinic: a Feasibility Study
This is a study of the feasibility of a translational research clinic for pregnancies conceived by in vitro fertilisation (IVF).
- Conditions
- Pregnancy Complications, IVF, Fetal Growth Retardation, Preeclampsia
- Trial name
- START (NCT04488861)
- Testing
- Non-interventional cohort study
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Manchester Academic Health Science Centre
Automatic Vitrification, Manual Vitrification
Interest of Automated Oocyte Freezing
In the space of a few decades, oocyte cryopreservation has become established in the world of reproductive biology with the authorization of oocyte vitrification.
- Trial name
- Instruvit (NCT03570073)
- Testing
- Manual vitrification, Vitrification with GaviTM system
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Poor Ovarian Response, Accupuncture
Acupuncture for Treatment of Patients With Poor Ovarian Response
This prospective randomized controlled trial is designed to investigate the effect of acupuncture on IVF/ICSI outcome in women with poor ovarian response.
- Trial name
- NCT04013984
- Testing
- Accupuncture
- Where
- Iran
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Infertility, Female
Physical Activity and Fertility Care Study
Randomized control trial to determine if performing the US Health and Human Services recommended amount of weekly physical activity during ovarian stimulation will differentially affect mental health or clinical outcomes of…
- Trial name
- PACE (NCT04002414)
- Testing
- Sufficient physical activity, Insufficient physical activity
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Low Responder
Oxidative Stress-related Gene Expression in Cumulus Cells Among Low Responders
In Vitro Fertilization is considered one of effective treatment for infertile couple. However, some women do not have adequate response to controlled ovarian hyperstimulation, resulting in low response which defined as less than…
- Trial name
- NCT03155438
- Testing
- Oxidative stress-related gene expression (RNA expression), oocyte competence biomarkers
- Where
- Thailand
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Pregnancy
Ghrelin Levels in Early IVF Pregnancies
In this study, we have assessed the potential prognostic value for gestational outcome of maternal ghrelin levels at very early stages of IVF pregnancies.
- Trial name
- NCT00469807
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Endometrial Diseases
Intrauterine Microbiota During IVF in Patients Affected With Isthmocele.
To evaluate the endometrial and isthmic microbiota in patients with isthmocele after C-Section, and if this microbiota is similar or not with better reproductive outcomes.
- Trial name
- NCT03519763
- Testing
- ultrasound
- Where
- United Arab Emirates
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Single Embryo Transfer of a Euploid Embryo Versus Double Embryo Transfer
This study seeks to compare the pregnancy and delivery rates of patients who undergo a single embryo transfer, when the embryo has been tested and determined to be chromosomally normal, with pregnancy and delivery rates of…
- Trial name
- NCT01408433
- Testing
- Single Embryo Transfer, Double embryo transfer
- Where
- 2 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Low Ovarian Reserve
The Effect of Growth Hormone in Assisted Reproductive Technology Clinical Outcome of Poor Responder
Assisted reproduction treatment in patients with low ovarian reserve is a big difficult clinical problem. Growth hormone (GH) is crucial in the development of follicles since preantral follicle to ovulation and can promote…
- Trial name
- NCT03027843
- Testing
- Growth Hormone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility Low Over Reserve, IVF
BPA Levels Relationship With IVF/ICSI Outcomes in Low Ovarian Reserve
The relationship between BPA elevation in urine, blood, and follicle fluid and embryo quality, IVF/ICSI outcomes.
- Conditions
- Infertility Low Over Reserve, IVF, Infertility, Female
- Trial name
- NCT04654598
- Testing
- BPA levels
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Nefise Nazlı YENIGUL
Infertility, Decreased Ovarian Reserve
A Trial of Dehydroepiandrosterone (DHEA) Treatment for in Vitro Fertilization (IVF)
Our long term goal is to elucidate the role of DHEA on follicular dynamics in the human ovary and to better understand the interaction of DHEA supplementation with other treatments for ovulation induction, especially among older…
- Trial name
- NCT00419913
- Testing
- Dehydroepiandrosterone
- Where
- 2 sites in United States, Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Luteal Phase Progesterone Levels
The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates
Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4…
- Trial name
- NCT04128436
- Testing
- Taking blood samples for analyzing progesterone levels
- Where
- 3 sites in Brazil, Denmark and 1 more
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Hacettepe University