Clinical trials: Ivf
Other Complications Associated With Artificial Fertilization
Efficacy of Luteinizing Hormone (LH) Activity in Low Responder Patients With Transdermal Testosterone
The investigators have previously demonstrated the utility of transdermal testosterone in in vitro fertilization (IVF) low responder patients.
- Trial name
- NCT01291212
- Testing
- Testosterone and FSHr-LHr, testosterone and FSHr alone
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Infertility
Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
This is a randomized, double-blind, single center clinical trial study to compare oocyte competence and risk of ovarian hyperstimulation syndrome (OHSS) after receiving the standard dose of human chorionic gonadotropin (hCG)…
- Trial name
- NCT02310919
- Testing
- Low dose hCG plus FSH co-trigger, Standard dose of hCG
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
Maternal Serum Cytokine Levels and Angiogenic Factor Levels in IVF vs Spontaneously Conceived Pregnancies
The objective of the study is to compare maternal levels of cytokines and angiogenic factors in IVF vs spontaneously conceived singleton pregnancies. The null hypothesis is that there will be no significant difference.
- Trial name
- NCT00837278
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MemorialCare
Repetition Failure
Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.
Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to persistent poor embryo quality.Mitochondria…
- Trial name
- NCT03639506
- Testing
- autologous mitochondria transplantation, autologous mitochondria from bone marrow mesenchymal stem cells into oocyte as well as intracytoplasmic sperm injection (ICSI), intracytoplasmic sperm injection (ICSI)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Fluid Uterus
Intracavitary Fluid and Position of C-section-scar
Does the presence of intracavitary fluid during hormonal stimulation for IVF depends on the position of C-section-scar ?
- Trial name
- NCT03518385
- Testing
- ultrasound,transvaginal scan
- Where
- United Arab Emirates
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Fertilization in Vitro, Infertility
The Impact of the Timing of Trigger on IVF Success
The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.
- Conditions
- Fertilization in Vitro, Infertility, Embryonic Development
- Trial name
- NCT02990949
- Testing
- Timing of trigger
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Reproductive Medicine
Embryo Implantation, Infertility
Clinical Trial of Novel Implantation Promoting Medium (EmbryoGlue) to Improve IVF Success Rates
Hypothesis: a special solution for improving human embryo implantation, when added to the solution during embryo transfer, will improve implantation rates in embryo transfers using previously frozen embryos.
- Trial name
- NCT00588250
- Testing
- EmbryoGlue
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pregnancy, Live Birth
Folic Acid and Zinc Supplementation Trial (FAZST)
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to…
- Conditions
- Pregnancy, Live Birth, Spontaneous Abortion
- Trial name
- FAZST (NCT01857310)
- Testing
- 5 mg folic acid and 30 mg elemental zinc
- Where
- 4 sites in United States
- Volunteers
- 2,370 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Estradiol Receptor Polymorphism, Progesterone Receptor Polymorphism
Gene-polymorphisms Relating to Human Subfertility
Estradiol is synthesized by granulosa cells of ovaries under control of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is known that Estradiol plays a crucial role in maturation and fertilization of oocytes.
- Conditions
- Estradiol Receptor Polymorphism, Progesterone Receptor Polymorphism, IVF, Subfertility
- Trial name
- NCT01385618
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Assisted Reproductive Technology
Progesterone Supplementation on Women Having Low Progesterone Levels on Transfer Day
The main objective of this study is to compare clinical pregnancy rates between two groups of women who have progesterone levels below 10 ng/mL on the day of frozen embryo transfer: group 1 (vaginal micronized progesterone…
- Trial name
- NCT04897269
- Testing
- Progesterone supplementation
- Where
- Vietnam
- Volunteers
- 824 people, healthy volunteers welcome
- Sponsor
- Tu Du Hospital
Infertility, In Vitro Fertilization Protocols
Evaluation of Granulosa Cells Function After IVF Protocols
This study is intended to evaluate ovarian cells after being submitted do different in vitro fertilization protocols. The investigators will analyze hormones secretion and intracellular mechanisms of these cells comparing the…
- Trial name
- NCT01946022
- Testing
- randomization between the two GnRH analogues (agonist and antagonist)
- Where
- 2 sites in Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
IVF, PCOS
Effect of GM-CSF on CAPA-IVM System Success Rates in PCOS
In-vitro maturation (IVM) of human oocytes obtained from minimally stimulated or unstimulated ovaries offers a more "patient friendly" treatment option than the conventional Assisted Reproductive Technology (ART) treatment with…
- Conditions
- IVF, PCOS, IVM
- Trial name
- NCT04774432
- Testing
- GM-CSF group, Control group
- Where
- Vietnam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Metabolic Syndrome, Diabetes
Metabolic Phenotyping of Individuals Born Following Assisted Reproduction Techniques
This study is to compare the effects of high fat overfeeding on metabolic risk factors in children born though assisted reproduction technologies (ART) versus children conceived naturally (controls).
- Trial name
- IMPART (NCT01230632)
- Testing
- high fat overfeeding
- Where
- Australia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin Antagonist on Reduction of Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban compared to placebo on uterine contractions on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- EFFORT (NCT01043120)
- Testing
- Barusiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
IVF Failure
Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development
The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF
- Trial name
- NCT03044561
- Testing
- Sildenafil Citrate
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility
Implantation Prediction by Three Dimensional (3D) Ultrasound in Fresh Embryo Transfers
This study is designed to predict implantation of a fresh, high quality embryo in an in vitro fertilization (IVF) cycle by using ultrasound based uterine factors.
- Trial name
- NCT02817373
- Testing
- Ultrasound scan performed through a vaginal probe
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Women Infertility
Myo-inositol/D-chiro-inositol Ratio in Follicular Fluid
Considering the importance assumed by follicular microenvironment for a proper oocyte development, this study is a prospective observational clinical trial which aims to evaluate whether the embryo blastocyst quality may be…
- Trial name
- NCT03055442
- Testing
- Dosage of myo-inositol, Dosage of D-chiro-inositol
- Where
- Greece
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Focus of Study Instead
Endometrial Injury Increases Implantation and Pregnancy Rates
Objective To evaluate the effect of local injury to the endometrium for implantation, pregnancy and live birth rates in ICSI -ET cycles with recurrent implantation failure. Design Randomized controlled clinical study.
- Trial name
- NCT01340560
- Testing
- Endometrial biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Fertilization
Lipidic Differences of Sperm Between Normal and Low Fertilization Patients
Although in vitro fertilization (IVF) involve the use of semen samples, there is little scientific methodology applied when selecting sperm.
- Trial name
- NCT04537481
- Testing
- Lipid extraction
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Infertility
A Benchtop Incubator Prospective Study
The use of extended embryo culture to the blastocyst stage and preimplantation genetic testing for aneuploidy (PGT-A) has enabled identification and selection of embryos with the best developmental potential and improved in vitro…
- Trial name
- NCT04969575
- Testing
- Insemination and culture, Media refreshment Group 1, Culture media preparation and refreshment
- Where
- United Arab Emirates
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC