Clinical trials: Ivf
Human Embryo Cryopreservation
Comparison Between Three Freezing Protocols to Preserve Human Embryos
This randomized study compares three different freezing methods to store human in vitro fertilization (IVF) embryos: vitrification with two commercial kits or slow freezing.
- Trial name
- NCT00910390
- Testing
- Slow freezing, VIT-Irvine, Vit-Vitrolife
- Where
- Belgium
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Infertility
Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031)
The purpose of this follow-up study is to collect the outcome and safety of FTET cycles after the embryos are cryopreserved in P06029 (NCT01144416).
- Trial name
- NCT01146418
- Testing
- Corifollitropin alfa, recFSH (follitropin beta)
- Volunteers
- 307 people
- Sponsor
- Organon and Co
Maternal Distress, Child Development
In Vitro Fertilization (IVF) and Prenatal Effects Independent of Genetics
This study examines how maternal stress during pregnancy affects infant brain and behavioral development, focusing on whether these effects are due to the prenatal environment or shared genes.
- Trial name
- NCT07296107
- Testing
- Prenatal maternal psychosocial and biological assessment protocol
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Progesterone Supplementation in Women Undergoing ART
Clinical Safety Study of the Progesterone Vaginal Ring in Women Undergoing Assisted Reproductive Technology Procedures
The purpose of the study is to assess the safety of Progesterone Vaginal Ring (PVR) in women undergoing fresh embryo transfer (ART).
- Trial name
- SARA (NCT03565211)
- Testing
- Progesterone vaginal ring
- Where
- 15 sites in United States
- Volunteers
- 352 people
- Sponsor
- Ferring Pharmaceuticals
Pregnancy Related, Pre-Eclampsia
Natural Versus Programmed Frozen Embryo Transfer (NatPro)
NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing frozen embryo transfer (FET) will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed…
- Trial name
- NatPro (NCT04551807)
- Testing
- Modified natural cycle, Programmed cycle
- Where
- 15 sites in United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- JHSPH Center for Clinical Trials
Female Infertility
A Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Intravaginal Micronized Progesterone Capsules 600 mg Daily for Luteal Support in In-Vitro Fertilization
Female inability to conceive a child. The purpose of this randomized, two-arm and double blind, double dummy study is to demonstrate that the treatment of a daily dose of 3x10mg dydrogesterone orally is as effective and safe as…
- Trial name
- Lotus I (NCT01850030)
- Testing
- Dydrogesterone 30 mg, Micronized Progesterone 600 mg
- Where
- 40 sites in Austria, Belgium and 5 more
- Volunteers
- 1,070 people
- Sponsor
- Abbott
Infertility, Female
Success Rate Natural Cycles Versus Modified Natural Cycles in Frozen Embryos
There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome.
- Trial name
- NCT03798886
- Testing
- natural cycle, modified natural cycle, embryo transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Infertility, Reproductive Techniques, Assisted
"Study of the Effects of Serum and Follicular Fluid Relaxin Levels on Ovarian Function in IVF Cycles"
The study evaluated the effect of serum relaxin and follicular fluid levels on the number and quality of oocytes, fertilization, the number and quality of the embryos in IVF protocols.
- Conditions
- Infertility, Reproductive Techniques, Assisted, Oocyte Maturation
- Trial name
- "Relaxifert" (NCT04458454)
- Testing
- Relaxin ELISA Kit
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Infertility, Tuberculosis
The Effect of Latent Tuberculosis Infection on the Pregnancy Outcome of IVF-ET
This study evaluate the effect of latent infection of tuberculosis on the pregnancy outcome of IVF-ET in infertile patients with radiographic lesions suggesting old healed tuberculosis
- Trial name
- NCT04443283
- Testing
- No intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University Third Hospital
ART
Effect of Vitamin D on Outcome of Assisted Reproductive Technology(ART);
Vitamin D has many biological functions. Vitamin D receptors are widely distributed in the male and female reproductive system. Animal experiments have shown that vitamin D deficiency can affect hormone synthesis and gamete…
- Trial name
- ART (NCT03804294)
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Peking University Third Hospital
Infertility
Single Dose Gonadotropin-releasing Hormone (GnRH) Agonist Administration in the Luteal Phase of GnRH Antagonist Stimulated ICSI-ET Cycles
GnRH agonist administration in the luteal phase was reported to beneficially affect clinical outcome of ICSI-ET cycles. This randomized controlled trial evaluates the effect of a single dose GnRH agonist administered in the…
- Trial name
- NCT01007851
- Testing
- triptorelin acetate, NaCl %0.9
- Where
- Turkey (Türkiye)
- Sponsor
- V.K.V. American Hospital, Istanbul
Infertility
Artificial Intelligence in Embryo Selection in Assisted Reproduction for Embryos Cultured to the Fifth Day of Development
Embryo selection is one of the major challenges in Assisted Reproductive Technology (ART) in order to continuously improve clinical pregnancy rates.
- Trial name
- IASEAMP (NCT07844083)
- Testing
- EMA
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Clermont-Ferrand
IVF, Controlled Ovarian Simulation
Menopur And Rekovelle Combination Study Version 2.0
The goal of this clinical trial is to evaluate the safety and effectiveness of a personalized ovarian stimulation regimen in women aged 18 to 40 undergoing in vitro fertilization (IVF).
- Conditions
- IVF, Controlled Ovarian Simulation, Fertility Disorders
- Trial name
- MARCS 2 (NCT06997900)
- Testing
- Combination therapy : Follitropin delta and HP-hMG
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Clinique Ovo
Diminished Ovarian Reserve
In Vitro Oocyte Maturation With Autologous Exosomes in Women
This study is a preliminary, prospective, randomized, controlled clinical trial designed to evaluate the safety and feasibility of supplementing in vitro maturation (IVM) media with autologous exosomes in women with diminished…
- Trial name
- Exosom2025-1 (NCT07249411)
- Testing
- MI oocytes were cultured in conventional IVM medium supplemented with 10 µg of autologous exosomes obtained using the ExoSMarT® exosome filtration system
- Where
- Venezuela
- Volunteers
- 32 people
- Sponsor
- Biotech Fertility C.A.
IVF
Speculum Insertion During Embryo Transfer
Lubrication gels are widely used in numerous gynecologic procedures in order to ease the insertion of speculum and visualize the cervix.
- Trial name
- NCT06210451
- Testing
- Sterile water-based gel
- Where
- Israel
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Infertility Unexplained, Fertility Disorders
Hypnofertility for Women Undergoing In Vitro Fertilization (HWUIVF)
This randomized controlled study aimed to specify whether the interventions based on Hypnofertility would lead to increased fertility preparedness and pregnancy outcomes, decreased cortisol levels of women undergoing In Vitro…
- Trial name
- NCT04141436
- Testing
- Interventions Based on Hypnofertility, Routine clinical procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Pregnancy, Neonates
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715)
The objective of this trial is to evaluate whether corifollitropin alfa (Org 36286) treatment for the induction of multifollicular growth in women undergoing controlled ovarian stimulation (COS) prior to in vitro fertilization…
- Trial name
- Care (NCT00702234)
- Testing
- Corifollitropin alfa, GnRH antagonist, (rec)hCG
- Volunteers
- 268 people
- Sponsor
- Organon and Co
Repeated Implantation Failure
A Randomized Double Blind Comparison of Atosiban in Patients With RIF Undergoing IVF Treatment
This study intends to carry out a prospective, randomized, double blind and controlled study to compare the influence of Atosiban and placebo on uterine contraction frequency, endometrial blood flow perfusion, oxytocin and serum…
- Trial name
- NCT02893722
- Testing
- atosiban, 0.9% saline
- Volunteers
- 200 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
ICSI
Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization
The role of progesterone (P) supplementation in the luteal phase of in vitro fertilization (IVF) cycles is well established world-wide , but the influence of the luteal phase estradiol level on implantation is not clearly defined…
- Trial name
- NCT03788681
- Testing
- Estradiol Valerate
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
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