Clinical trials: Joint Replacement
Hip Replacement Arthroplasty
Comparison Between Two Techniques of Volemic Expansion in Hip Replacement Arthroplasty
Currently the most use solution to volemic reposition in hip replacement arthroplasty is the crystalloid solution. This trial intends to compare two different volemic replacements: HES and Ringer's lactate.
- Trial name
- NCT00542516
- Testing
- Hydroxyethyl Starch, Ringer's lactate
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Osteoarthritis, Hip
Peri-Operative Testosterone Administration in Primary Total Hip Arthroplasty
It is often observed that patients following total hip replacement have a hard time with rehabilitation, as patients commonly lose muscle mass and strength around the surgical site.
- Trial name
- NCT06608914
- Testing
- Nandrolone decanoate, Saline
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- American Hip Institute
Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\)
Suzetrigine in Total Hip Arthroplasty
Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\), Total Hip Replacement, Total Hip Replacement Surgery
- Trial name
- NCT07226700
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Tourniquet and Outcome After Total Knee Replacement
The Effect of the Tourniquet in Bilateral Total Knee Replacement
This study describes in a randomised controlled trial how the tourniquet influence the outcome af a total knee replacements
- Trial name
- NCT06228651
- Testing
- Tourniquet, The leg without the tourniquet
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
ARTHROPLASTY, REPLACEMENT
American Joint Replacement Registry
The American Joint Replacement Registry is a not-for-profit 501(c)(3) organization for data collection and quality improvement initiatives for total hip and knee replacements.
- Trial name
- AJRR (NCT01909375)
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- American Joint Replacement Registry
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Osteoarthritis, Knee, Arthroplasty
Comparison of Three Knee Replacements
The present randomized controlled trial is designed to compare one novel total knee replacement (TKR) design and two conventional TKR designs in terms of functional outcome.
- Conditions
- Osteoarthritis, Knee, Arthroplasty, Total Knee Replacement
- Trial name
- NCT03339557
- Testing
- NexGen, Persona, PFC
- Where
- Finland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Coxa, Hospital for Joint Replacement
Pain, Spinal Surgeries, Hip and Knee Joint Replacement, Adverse Events
RAHM Foundation Retrospective Study of Various Diseases
This is a retrospective data collection on treatment of various disorders. This registry will include a variety of different products, implants, technologies and procedures.
- Trial name
- NCT02359786
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Rahm Foundation
Hip Dysplasia
The Influence of Hip Replacement on Lower Extremity Hemodynamics in Crowe IV Hip Dysplasia Patient
Explore the influence of hip replacement on lower extremity hemodynamics in Crowe Ⅳ hip dysplasia patient.
- Trial name
- NCT04157842
- Testing
- total hip replacement with subtrochanteral osteotomy, total hip replacement with no osteotomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Metallosis, Pain
Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty
The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems.
- Conditions
- Metallosis, Pain, Total Hip Replacement, Total Knee Replacement
- Trial name
- NCT04166539
- Testing
- Questionnaires, Interviews, Blood draw
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Morbid Obesity
Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
Does weight loss surgery in patients with morbid obesity prior to knee replacement surgery improve outcomes from knee replacement surgery
- Trial name
- OMEOSKO (NCT05120492)
- Testing
- bariatric surgery followed by total knee replacement
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Total Knee Arthroplasty, Pain Management
Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel
A prospective, randomized control study will be conducted to compare postoperative pain control in a series of patients treated with either: 1. a local cocktail. 2. a local cocktail plus Exparel. 3.
- Trial name
- NCT02571283
- Testing
- Cocktail, Exparel, Marcaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Tourniquets, Knee Arthroplasty, Total
Tourniquet Pressure in Primary Total Knee Arthroplasty
This proposed novel randomized control trial (RCT) seeks to address this gap in TKA protocol by gaining a better understanding of the relationship between tourniquet pressure and time, and intraoperative performance and…
- Conditions
- Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
- Trial name
- NCT02830087
- Testing
- Tourniquet Cuff Pressure
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Hip Osteoarthritis
Continuation of Patient Follow-up to 2 Years for the Pinnacle RSA and Pinnacle DM RSA Clinical Trials
The proposed study is a continuation of two prospective, multi-centre, non-controlled studies of the Pinnacle and Pinnacle Dual Mobility total hip arthroplasty systems, originally initiated by DePuy Synthes (DSJ_2018_02 and…
- Trial name
- NCT05930067
- Testing
- Pinnacle Gription Acetabular Cup, Pinnacle Dual Mobility
- Where
- 2 sites in Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Hip Replacement Arthroplasty
Serum Level of Cobalt and Chromium After Ceramic on Metal Articulation Total Hip Arthroplasty
Primary objectives: 1. To measure serum metal ion levels (blood Chromium (Cr) and Cobalt (Co) ion concentration) in patients that received the Ceramic on Metal arthroplasty of hip and who have well functioning primary total hip…
- Trial name
- CoM (NCT02346513)
- Testing
- Ceramic on Metal Articulation, Non-Ceramic on Metal Articulation
- Where
- South Korea
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Genu Varum, Knee Osteoarthritis
Effect of RO On GB During TKR Severe Varus Deformity
Effect Of Reduction Osteotomy On Gap Balancing During Total Knee Replacement For Severe Varus Deformity
- Trial name
- NCT03065738
- Testing
- tibial reduction osteotomy in total knee replacement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis, Knee
Unicompartmental Knee Arthroplasty (UKA) Versus Total Knee Arthroplasty (TKA) of Medial Osteoarthritis
This study allows patients to take part of the decision making between a unicompartment knee (partial ) or a total Knee replacement .
- Trial name
- NCT03457051
- Testing
- Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis
FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry
Aim 1. Establish a national registry of diverse patients of orthopedic surgeons representing all regions of the country and varied hospital and surgeon practice settings (e.g., urban/rural, low and high volume) to ensure that…
- Trial name
- FORCE-TJR (NCT02566473)
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester