Clinical trials: Juvenile-Onset Diabetes
Type1diabetes
Food Literacy and Type 1 Diabetes
The objective of the current study is to assess the prevalence of poor food literacy in young adults with type 1 diabetes through a national on-line survey.
- Trial name
- NCT03588234
- Where
- Canada
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- McGill University
Diabetes Mellitus, Type 1
Acceptability of Self-Led Mindfulness-Based Intervention
This study had two primary aims. First, the investigators examined the associations between mindfulness and diabetes-related outcomes.
- Trial name
- NCT05115175
- Testing
- Mindfulness-Based Stress Reduction
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Type 2 Diabetes, Osteoporosis
Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes
The DIACTIVE study is a randomized controlled trial with a 5- year follow-up designed to evaluate the impact of comprehensive screening and multicomponent interventions on fall prevention, bone health, nerve function and…
- Conditions
- Type 2 Diabetes, Osteoporosis, Diabetic Neuropathies, Fall Prevention
- Trial name
- DiaACTIVE (NCT06745544)
- Testing
- Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL)
- Where
- Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Type 1 Diabetes
Pilot Clinical Trial of Ustekinumab in Patients With New-onset T1D
In type 1 diabetes (T1D), immune defense cells in the body attack and destroy insulin-producing beta cells leaving affected people with a lifelong need for daily insulin injections.
- Trial name
- UST1D (NCT02117765)
- Testing
- Ustekinumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Diabetes
Resistance Exercise in Already-active Diabetic Individuals (READI) Trial
The purpose of the READI tiral is to examine the effects of resistance training (weight training) on the blood sugar control of aerobically active individuals with Type 1 Diabetes.
- Trial name
- NCT00410436
- Testing
- Resistance Exercise
- Where
- 3 sites in Canada
- Volunteers
- 131 people
- Sponsor
- Ottawa Hospital Research Institute
Non Insulin Dependent Diabetes
Curcumin Supplementation and Patients With Type 2 Diabetes
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects.
- Trial name
- NCT02529982
- Testing
- Curcumin
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Assess the Efficacy and Safety of NovoRapid™ Flexpen™
This study is conducted in Asia. The aim of this observational study is to collect efficacy and safety data in diabetic patients with acute hyperglycemia using NovoRapid™ FlexPen™ as per normal clinical practice.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00675220
- Testing
- insulin aspart
- Where
- Philippines
- Volunteers
- 373 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Insulin-Dependent
Psychosocial Issues in Insulin Pump Therapy in Children With Type 1 Diabetes Mellitus (DM)
The effect of change in diabetes treatment from multiple daily insulin injection therapy to continuous subcutaneous insulin infusion on psychosocial outcome measures (quality of life, diabetes burden, parents stress level, fear…
- Trial name
- pumpkin (NCT01338922)
- Testing
- Continuous subcutaneous insulin infusion therapy, Multiple daily injection therapy
- Where
- 24 sites in Germany
- Volunteers
- 211 people
- Sponsor
- University Hospital Schleswig-Holstein
Type 1 Diabetes
The Effects of Mediterranean Diet on Remission, Lipid Profile, Weight and Body Composition in Children and Adolescents With Newly Diagnosed Type 1 Diabetes
Nutritional therapy has a major role in diabetes care, achieving and maintaining metabolic control: normal glucose homeostasis, normal lipid profile, normal blood pressure and desirable weight.
- Trial name
- NCT02131896
- Testing
- Interventional arm-Mediterranean diet, Control Arm- regular nutritional instructions in accordance with the accepted nutritional guidelines
- Where
- Israel
- Volunteers
- 4 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes, Hypoglycemia
Effect of Continuous Glucose Monitoring on Course of Glucose in Type 1 Diabetes
The objective of this cross over study is to access if continuous glucose monitoring (CGMS) with a real time feed back and hypoglycemic as well as hyperglycemic glucose alerts vs.
- Trial name
- NCT00467688
- Testing
- Real time access to current glucose values during CGMS
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Diabetes Mellitus, Type 1
Pharmacist Led Educational Intervention on QOL, Medication Adherence & Satisfaction on Patients With Type 1 DM
There was no previous study in Iraq to evaluate the efficacy of pharmacist-led educational intervention on patient glycemic control, quality of life and medication adherence among type 1 diabetic patients in Iraq.
- Trial name
- NCT06547970
- Testing
- Educational intervension
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- University of Baghdad
Erectile Dysfunction, Erectile Dysfunction Following Radical Prostatectomy
Penile Implant Intraoperative Measurements Planning Chart
This is a chart of penile size measurements where penile length and width are recorded intra-operatively prior to penile prosthesis implantation to guide the surgeon to the correct and adequate post-operative penile size
- Conditions
- Erectile Dysfunction, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction With Diabetes Mellitus, Erectile Dysfunction Due to Arterial Disease
- Trial name
- PIIMP (NCT05531877)
- Testing
- Penile Prosthesis Implantation
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Type 1 Diabetes
11C-5-HTP PET in Clinical Islet Transplantation
In people with type I diabetes, the insulin producing cells in the pancreas have been destroyed. Presently one can only evaluate the function of the graft through laboratory tests, blood sugars and the insulin requirements.
- Trial name
- NCT02689479
- Testing
- Positron-Emission Tomography, 11C-5-HTP, Magnetic Resonance Imaging
- Where
- 2 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes type1, Children, Only
Evaluation of the MiniMed 780 System in Paediatric Subjects
The purpose of this study is to demonstrate the safety and performance of the MiniMed™ 780G system in pediatric subjects (2-6 years old) with type 1 diabetes in a home setting.
- Trial name
- LENNY (NCT05574062)
- Testing
- MiniMed 780G Auto Mode with G4S sensor, MiniMed 780G Manual Mode with G4S sensor, MiniMed 780G Auto Mode with DS5 sensor
- Where
- 12 sites in Finland, Italy and 2 more
- Volunteers
- 101 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
Combined Basal-bolus Insulin and Post-exercise Carbohydrate Feeding Strategy in T1DM
The investigators hypothesise that reducing basal insulin dose (Glargine, Lantus, Sanofi-Aventis, or Detemir, Levemir, Novo Nordisk), whilst employing current carbohydrate feeding and rapid-acting insulin dose recommendations…
- Trial name
- NCT02204839
- Testing
- Basal insulin dose
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Northumbria University
Type 1 Diabetes
Risk Factors of Metabolic Control in Children and Adolescents With Type 1 Diabetes
Background: Type 1 diabetes is one of the most common chronic illnesses among children and adolescents. Although, intensive medical care is provided for these patients, some of them have poor metabolic control.
- Trial name
- NCT03642470
- Where
- Switzerland
- Volunteers
- 197 people
- Sponsor
- University Children's Hospital, Zurich
Diabetes Mellitus, Type 1
Phase 2 Study of Adaptive Insulin Meal Supervisor (AIMS) in Adults With Type 1 Diabetes Mellitus
In this study, a closed-loop Adaptive Insulin Meal Supervisor system (AIMS) utilizing continuous glucose monitoring (CGM), a subcutaneous insulin pump and standard pramlintide therapy will be applied in individuals with type 1…
- Trial name
- NCT01839370
- Testing
- Closed Loop with Pramlintide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Virginia
Diabetes Mellitus
Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency
The etiology of immune-mediated diabetes mellitus (IMD) remains unclear. However, previous studies indicate that autoimmunity may be a result of dysfunction of natural killer T cells (NK-T cells).
- Trial name
- NCT00011141
- Testing
- Oral lactobacillus administration
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Breast Cancer (Locally Advanced or Metastatic)
GB268 Monotherapy or Combination Therapy for Locally Advanced/Metastatic Breast Cancer (Phase Ib/Ⅱ)
This is a Phase Ib/II, open-label, multi-cohort, multi-center study to evaluate the safety, tolerability, and preliminary anti-tumor activity of GB268, a biological product, as monotherapy or in combination with other therapies…
- Trial name
- NCT07738341
- Testing
- GB268, Nab-Paclitaxel, Datopotamab Deruxtecan (Dato-DXd)
- Volunteers
- 270 people
- Sponsor
- Eddingpharm (Zhuhai) Co., Ltd.
Type 1 Diabetes Mellitus
Insulin Sensitivity, Impaired Counterregulation, and Glucose Variability
This protocol will investigate physiological parameters including insulin sensitivity and counterregulatory function using a mixed meal test and induced hypoglycemia in subjects with type I diabetes.
- Trial name
- BPK005 (NCT01439672)
- Testing
- Mixed meal and insulin challenge
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia