Clinical trials: Keloids
Keloid, Tattoo
Tattooing and Piercing Among Medical Students
The aim of this study is to evaluate medical students' attitudes towards tattoos and piercings and to measure their awareness of associated dermatological risks.
- Conditions
- Keloid, Tattoo, Infection, Scar
- Trial name
- NCT07673484
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Biruni University
Keloids, Fibroblast
Keloid Pathogenesis And Fibroblast Activation Study
Keloids are benign fibroproliferative skin disorders characterized by excessive fibroblast activation and extracellular matrix deposition. The molecular mechanisms underlying keloid formation remain incompletely understood.
- Trial name
- KPS (NCT07682636)
- Testing
- Tissue Collection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Keloid
Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury.
- Trial name
- NCT05330078
- Testing
- Botulinum toxin type A, Vehicle
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hypertrophic Scar
Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars
Hypertrophic scarring is a difficult and debilitating condition where one develops excessive scarring after full thickness injury to the skin. This is very common in full thickness burn injury.
- Trial name
- NCT05259137
- Testing
- Intralesional enalaprilat injection
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Scar, Hypertrophic
Intralesional Treatment of Keloids
Intralesional injection in treatment of keloid
- Trial name
- NCT06729840
- Testing
- Injection
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University
Scar Keloid
Botulinum Toxin Type a Injection to Prevent Keloid Recurrence
The prospective, split-scar, double-blind, randomized controlled study will enroll the patients who are older than 20 years with progressive keloid lesion which is symmetric.
- Trial name
- NCT05072821
- Testing
- Botulinum Toxin Type A Injection [Botox], 0.9% Sodium Chloride Injection
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Keloid, Cicatrix
Photobiomodulation and the Intralesional Administration of Corticoid in the Keloid Surgery.
A randomized, controlled, double-blind, clinical trial will be conducted to study the evaluate the effect of blue light combined with corticoid treatment in the preoperative and postoperative period of keloid removal surgery.
- Trial name
- NCT04824612
- Testing
- Photobiomodulation with blue led, Triamcinolone Hexacetonide
- Where
- Brazil
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Keloid, Wound Heal
Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches.
- Conditions
- Keloid, Wound Heal, Wound
- Trial name
- NCT06138964
- Testing
- siSPARC + siLR4A microneedle patches, siSPARC microneedle patch
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Skin Centre
Keloid
Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar
Purpose: To compare the levels of matrix metalloproteinase-1 (MMP-1), MMP-8, MMP-13 and tissue inhibitor of metalloproteinases (TIMPs) in keloid skin tissue with normal skin in the same patient and with normal discarded skin…
- Trial name
- NCT01125137
- Testing
- Removal of Keloid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Keloid
Ethosomal Gel Bearing Losartan 5% for Keloid Treatment
The objectives are to compare the efficacy of pre and post-treatment and between 5% losartan potassium loaded in ethosomal gel and 10 mg/ml triamcinolone acetonide injection based on the indicator score of The patient and…
- Trial name
- NCT05893108
- Testing
- Ethosomal gel bearing losartan 5%, triamcinolone acetonide 10 mg/ml
- Where
- Indonesia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Yuni Eka Anggraini
Keloid, Keloid of Ear Lobe
Gene Expression and Biomarker Profiling of Keloid Skin
This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation. Hypothesis: 1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's…
- Conditions
- Keloid, Keloid of Ear Lobe, Healthy Adults
- Trial name
- NCT03228693
- Testing
- Biopsy and/or triamcinolone injection, Excisional Biopsy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Skin, Scar
Therapy of Scars and Cutis Laxa With Autologous Adipose Derived Mesenchymal Stem Cells
The aim of this study is to compare clinical outcomes of patients with large scars or Cutis laxa treated with injections of autologous stromal vascular fraction cells (SVF) and adipose-derived mesenchymal stem cells (ADSC).
- Conditions
- Skin, Scar, Cutis Laxa, Keloid
- Trial name
- 2ABC (NCT03887208)
- Testing
- Laser therapy, Autologous ADSC injection, Normal saline injection
- Where
- 3 sites in Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Skin Diseases, Hypertrophic Scar
Piezoelectric Drived Microneedling in Treating Refractory Skin Diseases
Piezoelectric drived microneedling treats refractory skin disorders using hollow microneedles assisted by ultrasound. Mechanically, the injection of medicine by hollow microneedling could makes the distribution of medicine more…
- Conditions
- Skin Diseases, Hypertrophic Scar, Keloid, Plantar Wart
- Trial name
- NCT05488860
- Testing
- Triamcinolone acetonide(scar)/5-ALA(others), Piezoelectric drived microneedling, 5-ALA (a photosensitizer for photodynamic therapy).
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Keloid, Keloid Scar Following Surgery
Post-Surgical Injection With Triamcinolone Versus Triamcinolone/Fluorouracil in Treatment of Keloids
There have been many modalities utilized in the treatment of keloids of the head and neck, however none have been universally successful.
- Trial name
- NCT04710719
- Testing
- Triamcinolone Injection, Triamcinolone Injection and 5-fluorouracil injection
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Fibrosis, Skin Scarring
Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention
Skin scarring (fibrosis) is a common complication in the wound healing process and remains a therapeutic challenge. Scar formation often occurs following injury to the skin such as surgery, trauma, and burns.
- Conditions
- Fibrosis, Skin Scarring, Skin Wound, Hypertrophic Scar
- Trial name
- NCT03795116
- Testing
- LED-RL phototherapy, Mock irradiation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Scar Keloid
Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars
Summary: Keloids and hypertrophic scars are benign fibrous growth, differing mainly by overgrowth beyond the initial defect in keloid whereas hypertrophic scar is confined to initial lesion and tends to regress over the years.
- Trial name
- NCT04812626
- Testing
- 5-Fluorouracil
- Where
- Nepal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Keloid
RAPA-Keloid Study of Keloid Regression
1. To test whether topical rapamycin regresses established keloids in humans by measuring surface area and height changes in the scar over time (6 months) 2.
- Trial name
- NCT04049552
- Testing
- Rapamycin 8% Ointment
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Keloid Scar
Proof of Concept (POC) Study of the Soliton's Acoustic Scar Reduction (ASR) Treatment for the Treatment of Keloid Scar
To evaluate the safety, and efficacy of the ASR device for the temporary improvement in the appearance of a keloids.
- Trial name
- ASR (NCT04016610)
- Testing
- Soliton's Acoustic Scar Reduction (SAR)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Soliton
Caesarean Wound, Hypertrophic Surgical Scar
: Protescal: Prevention of Hypertrophic Scar and Keloid Formation Post Caesarean Section
This study aimed to evaluate the effectiveness of Protescal in preventing post caesarean section hypertrophic scar and keloid formation.
- Conditions
- Caesarean Wound, Hypertrophic Surgical Scar, Keloid Scar Following Surgery
- Trial name
- NCT04951869
- Testing
- Protescal gel
- Where
- Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Keloid, Autologus Adipose Derived Stem Cells
Autologous Adipose Derived Stem Cells Transplantation in the Treatment of Keloids.
Keloids are the most common disfiguring skin disorder affecting colored population with a prevalence of upto 16%. Autologous adipose derived stem cells have been found to have potential therapeutic benefits however limited…
- Conditions
- Keloid, Autologus Adipose Derived Stem Cells, Feasibility, Safety
- Trial name
- NCT04553159
- Testing
- Autologous adipose derived stem cells
- Where
- Uganda
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Makerere University