Clinical trials: Kidney; Disease, Acute
Kidney Failure, Acute, Acute Kidney Insufficiency
Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery
This study proposes to investigate whether treatment with minocycline pre-operatively in patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce the occurence of kidney injury.
- Trial name
- NCT00556491
- Testing
- minocycline
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tarek M. El-Achkar
Hypertension, Acute Myocardial Infarction
PCI and Renal Denervation in Hypertensive Patients With Acute Coronary Syndromes
Research hypothesis: Is the treatment with renal denervation (RDN) early post ACS safe and effective and does it leads to improved cardiac function and attenuation of pathologic left ventricular remodelling? In a following study…
- Trial name
- COMBI-RDN (NCT02272920)
- Testing
- Renal denervation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Renal Cell Carcinoma (RCC), Renal Function Abnormal
Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
- Trial name
- NCT07497958
- Testing
- Ischemic preconditioning, NO ischemic preconditioning
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Sun Yat-sen University
Sickle Cell Disease Vaso-occlusive Crisis
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
This is a phase 2, randomized, multiple-dose, placebo-controlled study designed to evaluate the safety, efficacy, and pharmacokinetics (PK) of CSL889 (human hemopexin) when given intravenously (IV) to adults and adolescents with…
- Trial name
- NCT06699849
- Testing
- CSL889
- Where
- 30 sites in United States, Turkey (Türkiye) and 1 more
- Volunteers
- 70 people
- Sponsor
- CSL Behring
Acute Kidney Injury
Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity
The purpose of this study is to determine whether magnesium preloading reduce incident of cisplatin induced acute kidney injury in head and neck cancer who receiving low dose cisplatin (40 mg/m2 weekly for 7 weeks).
- Trial name
- PRAGMATIC (NCT02481518)
- Testing
- Magnesium, Control
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Acute Kidney Injury, Contrast-induced Nephropathy
Clinical Validation of the RENISCHEM L-FABP POC Assay
This study will involve measurement of levels of a novel urinary biomarker of renal ischemia, L-FABP. The purpose of the study is to perform a clinical validation of the ability of L-FABP measurements in urine using the RENISCHEM…
- Trial name
- SAKURA-POC (NCT04864847)
- Testing
- RENISCHEM L-FABP POC Test
- Where
- 6 sites in United States
- Volunteers
- 382 people
- Sponsor
- Hikari Dx, Inc.
Kidney Failure, Acute, Kidney Failure, Chronic
Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy?
The kidneys are highly vascular organs and any trauma or surgery poses risk of severe bleeding. Platelet function is an integral part of the blood clotting during the initial, so-called vascular phase.
- Conditions
- Kidney Failure, Acute, Kidney Failure, Chronic, Blood Platelet Disorders, Hemorrhage
- Trial name
- NCT00334204
- Testing
- measuring Platelet Function Analyser-100 (PFA-100) platelet function before kidney biopsy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Mississippi Medical Center
Metastatic Cancer, Cancer, Breast
Assessment of Sarcopenia at Diagnosis for Patients With Previously Untreated Metastatic Cancer or Hematologic Malignancy
Sarcopenia is defined as reduction in muscle mass and function according to the criteria of the European Working Group on Sarcopenia in older people.
- Conditions
- Metastatic Cancer, Cancer, Breast, Cancer Colon, Cancer, Rectum
- Trial name
- SPACE2 (NCT05154474)
- Testing
- Standard
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Weprom
Acute Renal Failure
Low Dose Thymoglobin in Renal Transplant Patients
This is a planned single center prospective randomized study evaluating the safety and efficacy of low dose thymoglobulin as induction agent in renal transplant recipients.
- Trial name
- NCT01280617
- Testing
- Thymoglobulin, Thymoglobulin 0.75mg/kg dose
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Lahey Clinic
Acute Cellular Graft Rejection, Liver Transplant Rejection
Budesonide for Immunosuppression After Liver Transplantation to Reduce Side Effects
Our hypothesis is that budesonide will provide effective hepatic ISP that will replace prednisone and allow lower systemic drug levels of FK, thus reducing the steroid- and calcineurin-associated complications often observed in…
- Trial name
- BILT (NCT03315052)
- Testing
- Budesonide, Tacrolimus（FK506）, Mycophenolate Mofetil
- Sponsor
- Montefiore Medical Center
Electrolyte Imbalances, Acute Kidney Injury
Investigation of Fluid- and Electrolyte Balance in Post Cardiac-surgery Patients
Critically ill patients need intravenous fluid therapy in order to correct or prevent problems with their fluid and/or electrolyte status and for renal protection.
- Trial name
- Clinibil (NCT02914782)
- Testing
- Observational Study
- Where
- Austria
- Volunteers
- 176 people
- Sponsor
- Medical University of Graz
END STAGE RENAL DISEASE
ESTEROID WITHDRAWAL STUDY, SAFETY AND EFFICACY IN RENAL TRANPLANTATION
BACKGROUND: Non-steroid maintenance immunosuppression after transplantation can improve long-term lipid and hemodynamic profiles without severe acute rejection (AR) events that alter graft function or survival.
- Trial name
- ESWMEX001 (NCT02328222)
- Testing
- ESW group
- Where
- Mexico
- Volunteers
- 71 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Chronic Allograft Nephropathy, Chronic Kidney Disease
Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients
Hyperparathyroidism (HPT) is common in people with a kidney transplant. Patients with HPT often have high parathyroid hormone (PTH) levels and may have large parathyroid glands in the neck.
- Conditions
- Chronic Allograft Nephropathy, Chronic Kidney Disease, Chronic Renal Failure, Disordered Mineral Metabolism
- Trial name
- NCT00975000
- Testing
- Cinacalcet
- Where
- 51 sites in United States, Australia and 9 more
- Volunteers
- 114 people
- Sponsor
- Amgen
Neurotoxicity, Sepsis
Neurotoxicity Evaluation of Beta-lactams in Intensive Care Unit and Identification of the Risk Factors
Beta-lactams are the most prescribed antibiotics in intensive care units. The lack of linearity between the dose administered and the exposition due to the very high variability of the pharmacokinetics in critically ill patients…
- Conditions
- Neurotoxicity, Sepsis, Beta Lactams, Therapeutic Drug Monitoring
- Trial name
- NebuLar (NCT03628300)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Delayed Graft Function
Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant
Delayed graft function occurs in more than 20% of kidney transplantations. It is an episode of post-ischemic acute kidney injury with long-term consequences on the allograft's function.
- Trial name
- GABRIEL (NCT05513807)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Incidence and Spectrum of Acute Kidney Injury in Cirrhotics and Assessment of New Biomarkers as Early Predictors of Acute Kidney Injury
500 patients with normal renal function will be prospectively studied and incidence, spectrum and natural history of AKI (Acute Kidney Injury) will be observed in them and in 200 patients with abnormal renal function fulfilling…
- Trial name
- NCT02016053
- Where
- India
- Volunteers
- 450 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Contrast-induced Nephropathy, Kidney Injury
Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease
The use of contrast media (CM) poses a risk of post-contrast acute kidney injury (PC-AKI), especially among patients chronic kidney disease (CKD).
- Conditions
- Contrast-induced Nephropathy, Kidney Injury, Kidney Failure, Chronic, Risk Reduction
- Trial name
- ENRICH (NCT05283512)
- Testing
- Preventive treatment with IV-hydration, Preventive treatment with oral hydration
- Where
- Denmark
- Volunteers
- 254 people
- Sponsor
- Odense University Hospital
Acute Kidney Injury
Bicarbonate in Cardiac Surgery
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- NCT00878956
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 427 people
- Sponsor
- Austin Health
Acute Heart Failure, Chronic Kidney Diseases
Empagliflozin in Acute Heart Failure
The objective is to study in a prospective, interventional, single arm, cohort study the potential synergistic diuretic effect of empagliflozin, in addition to furosemide, in hypervolemic patients admitted with acutely…
- Trial name
- DRIP-AHF-1 (NCT05305495)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ureteral Obstruction, Neoplasms
Antibiotic Prophylaxis in Percutaneous Nephrostomy Placements and Replacements for Malignant Urinary Tract Obstruction
This study aims to find out whether taking antibiotics to prevent a urinary tract infection after a medical procedure called percutaneous nephrostomy (placement of a catheter directly into the kidney to keep it working after the…
- Conditions
- Ureteral Obstruction, Neoplasms, Acute Kidney Injury, Nephrostomy; Complications
- Trial name
- NCT06801405
- Testing
- antibiotic prophylaxis
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Barretos Cancer Hospital
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