Clinical trials: Kidney
ACS - Acute Coronary Syndrome
Evaluate the Effects of Renal Impairment on the Pharmacokinetics and Pharmacodynamics
The study is a multicenter, Phase 1, open-label, sequential, adaptive, single dose, PK/PD study in subjects with moderate and severe RI and healthy volunteers (HV).
- Trial name
- NCT05323136
- Testing
- MT1002 for Injection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Shaanxi Micot Pharmaceutical Technology Co., Ltd.
Diabetes, Hypertension
The Integrated Population (I-POP) Health Trial
The primary aim of this study is to determine whether community health worker (CHW) navigation improves outcomes of chronic disease and chronic disease risk factors in a low-income, primarily ethnic minority population when…
- Conditions
- Diabetes, Hypertension, Chronic Kidney Diseases, Obesity
- Trial name
- I-POP (NCT04761016)
- Testing
- Usual Care, I-POP + CHW navigation
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Tumor, Carbonic Anhydrase IX
Exploring the Clinical Application Value of CAIX-Targeted PET Imaging in Renal Cancer Patients
To evaluate the efficacy of targeted CAIX-specific probe PET imaging in the diagnosis and staging of kidney cancer, as well as to assess its role in prognosis prediction and treatment evaluation for kidney cancer.
- Trial name
- NCT06956144
- Where
- China
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xiamen University
End-Stage Kidney Disease (ESKD)
Pharmacokinetics of Oral Letermovir in Adults With End-Stage Kidney Disease With or Without Haemodialysis
This study aims to understand how the antiviral medication letermovir (PREVYMIS) is processed by the body in adults with end-stage kidney disease (ESKD), including those who are receiving intermittent haemodialysis and those who…
- Trial name
- NCT07101055
- Testing
- Letermovir 480 mg [PREVYMIS]
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jason A Roberts
Liver Transplantation
Intact Liver Innervation and Glucose and Glucagon-like Peptide-1 (GLP-1) Induced Insulin Secretion
The aim of the study is to investigate the significance of intact nerve supply to the liver for the glucagon-like peptide-1 (GLP-1) induced insulin secretion.
- Trial name
- NCT01176708
- Testing
- dipeptidyl peptidase 4 (DPP4) inhibitor, oral glucose, intravenous glucose
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Acute Kidney Injury
Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types
This study was a pilot, safety, and pharmacokinetic study of MB-102 versus iohexol and the use of the non-invasive optical renal function monitor (ORFM) device in normal and compromised renal function participants with different…
- Trial name
- NCT02772276
- Testing
- MB-102-- single dose of 4 µmol/kg, MB-102-- single dose of 130 mg, MB-102-single dose of 130 mg or 2 doses of 130 mg 12 hours apart
- Where
- 3 sites in United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- MediBeacon
End Stage Renal Failure on Dialysis, End Stage Renal Disease on Dialysis
Human Factors Validation Testing for the Peripal System; a Manual Connection Assist Device for Peritoneal Dialysis Devices
It is estimated that there are currently over 3 million patients receiving dialysis treatment worldwide. With effective pre-dialysis counselling, a majority of patients choose the home-based therapy peritoneal dialysis (PD) but…
- Conditions
- End Stage Renal Failure on Dialysis, End Stage Renal Disease on Dialysis, Renal Failure, Peritoneal Dialysis
- Trial name
- NCT04292210
- Testing
- Perisafe
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Peripal AG
End Stage Renal Disease, Nutrition
Endocannabinoids in End Stage Renal Disease
To investigate the relationship between dietary intake, body habitus, and endocannabinoid levels in end stage renal disease patients as compared to matched controls.
- Trial name
- NCT01477515
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Uremic Pruritus
Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
This is a single-center clinical research study with the purpose to evaluate the safety, tolerability, and pharmacokinetics (PK) of nalbuphine HCl ER (extended release) tablets in end-stage renal disease (ESRD) patients receiving…
- Trial name
- NCT02373215
- Testing
- Nalbuphine HCL ER
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Trevi Therapeutics
Kidney Disease, Kidney Disease, Chronic
Rutgers University Study of the Genetics of Kidney Disease
The goal of this observational study is to learn more about how genes impact the risk of kidney disease. Anyone 18 or older living in the US is eligible, and a diagnosis of kidney disease is NOT required.
- Conditions
- Kidney Disease, Kidney Disease, Chronic, Kidney Disease, End-Stage, Kidney Diseases
- Trial name
- rugcc-kd (NCT07217535)
- Testing
- Saliva sample, Health surveys
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Melanoma
Culture and Characterization of Circulating Tumor Cells (CTC) in Melanoma and Other Cancers
The purpose of this study is to determine if circulating tumor cells (CTC) can be accurately detected and isolated from the blood of participants with melanoma using novel laboratory techniques.
- Trial name
- CTC (NCT01528774)
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wolfram Samlowski
Healthy, Chronic Kidney Diseases
Effect of the Consumption of Ferric Hydroxide Adipate on Urinary Phosphorus Excretion.
Ferric hydroxide adipate is a ferric iron supplement containing iron hydroxide and a dietary organic acid that was developed at MRC Human Nutrition Research.
- Trial name
- NCT01991574
- Testing
- Calcium acetate, Iron Hydroxide Adipate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
Renal Colic
Evaluation of the Roll of IV Fluids in the Treatment of Renal Colic
A randomised controlled trial to evaluate the role of IV fluids in renal colic.
- Trial name
- NCT03529097
- Testing
- 0.9% Sodium-chloride, Optalgin, Voltaren, Morphine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
IgA Nephropathy
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics Pharmacodynamics of SHR-2010 by Intravenously/Subcutaneously in Healthy Subject
The study is being conducted to Evaluate the Safety, Tolerability and Pharmacokinetics pharmacodynamics of SHR-2010 by intravenously/subcutaneously in Healthy Subject.
- Trial name
- NCT05398510
- Testing
- SHR-2010 injection
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Chronic Renal Insufficiency
An Ascending Dose Study to Assess Safety, Tolerability, PK/PD of LHW090 in Healthy Volunteers and in Subjects With Renal Dysfunction
The purpose of the study is to provide pertinent information to enable decisions regarding the developability of LHW090 for use in patients with chronic renal insufficiency, including a comparison of the potential risk-benefit…
- Trial name
- NCT01846468
- Testing
- LHW090
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
IgA Nephropathy
Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN)
Multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of BION-1301 in healthy volunteers and adults with IgA Nephropathy (IgAN).
- Trial name
- NCT03945318
- Testing
- BION-1301 Single Dose, BION-1301 Multiple Doses
- Where
- 16 sites in United States, South Korea and 1 more
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Cocaine Dependence
Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.
This proposal describes a combined laboratory and clinical trial preliminary investigation to advance medication development for cocaine dependence.
- Trial name
- NCT02255357
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Kidney Disease, Chronic
Testing Educational Videos on Conservative Kidney Management
This study aims to test the efficacy of a series of just-in-time educational videos on topics related to CKM (CKM-EMPOWER) in improving nephrology providers ability to provide CKM.
- Trial name
- CKM-EMPOWER (NCT06577571)
- Testing
- CKM-EMPOWER
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Washington
Secondary Hypogonadism
Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function
To determine and compare the pharmacokinetics (PK) of a single dose of 25 mg Androxal in overweight male subjects with various stages of renal impairment and in volunteers with normal renal function.
- Trial name
- NCT01923857
- Testing
- Androxal 25 mg
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
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