Clinical trials: Kidney Dysfunction
Renal Insufficiency
PK Study of ACHN-490 Injection in Renally Impaired Subjects
The purposes of this study is to assess the relationship between renal function and pharmacokinetics of ACHN-490 Injection.
- Trial name
- NCT01462136
- Testing
- ACHN-490 Injection
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Achaogen, Inc.
Renal Insufficiency, Chronic
Explore New Magnetic Resonance Technology in Assessment of Renal Dysfunction
Currently, renal biopsy is the gold standard for evaluating renal pathology and renal fibrosis, but it is invasive and carries the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is…
- Trial name
- NCT06366529
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhen Li
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Chronic Kidney Disease
Depressed Cardiac Autonomic Modulation in Patients With Chronic Kidney Disease Diagnosed by Spectral Analysis
Background/Aims: To evaluate the sympathovagal balance in patients with chronic kidney disease (CKD) on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD…
- Trial name
- HRV (NCT01376635)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Core Educational Research and Treatment in Nephrology
Chronic Kidney Disease
Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death.
- Trial name
- NCT01028703
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Heat Strain, Healthy Volunteer Study
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers.
- Conditions
- Heat Strain, Healthy Volunteer Study, Kidney Dysfunction
- Trial name
- NCT06983730
- Testing
- Vitamin B3
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Hyperprolactinemia, Thyroid Dysfunction
Develop and Implement Methods for Diagnostic and Treatment of Hormonal Disorders in Patients With Chronic Kidney Disease
Methods of diagnostic and treatment of hormonal disorders in patients with chronic kidney disease (CKD) will be developed and implemented in real clinical practice.
- Conditions
- Hyperprolactinemia, Thyroid Dysfunction, Bone Diseases, Metabolic, Chronic Kidney Diseases
- Trial name
- NCT04439747
- Testing
- Ultrasound, DXA, hormonal tests
- Where
- Belarus
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Belarusian State Medical University
Heart Failure, Asymptomatic Systolic Dysfunction
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function
The following are done for screening procedures to determine if patients are eligible for this study: blood count, kidney and liver blood tests. Patients will complete a 6-minute walk test.
- Trial name
- NCT00405639
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Success Rate, Self-Efficacy
Success, Academic Self-efficacy; ARCS Model
Cassels and Redman have offered some suggestions such as teaching students basic ethical principles and theories, the International Council of Nurses (ICN) Code of Ethics, and the rights and laws of nurses in all kinds of ethical…
- Trial name
- NCT06887790
- Testing
- Education method (ARCS)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Occurrence of Renal Dysfunction (GFR ≤ 60mL/(Min·1.73m2)) in Renal Transplant Recipients Within One Year After Kidney Transplantation
Multimodal Ultrasound in DBD Kidneys for Predicting Early Postoperative Renal Insufficiency Risk
The objective of this observational study is to investigate the multimodal ultrasound parameters of kidneys from brain-dead organ donors prior to donation, in order to construct a predictive model for assessing the risk of early…
- Trial name
- NCT07090512
- Testing
- Multimodal Ultrasound
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bei Wang
Dyslipidemias, Children, Only
The Effect of Childhood Dyslipidemia on Endothelial and Renal Function
The aim of the study is to assess if abnormal lipid levels in childhood could cause early damage of the inner layer of the vessels, the endothelium.
- Conditions
- Dyslipidemias, Children, Only, Endothelial Dysfunction, Renal Dysfunction
- Trial name
- NCT03856476
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Acute Renal Failure, Chronic Kidney Failure
The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.
- Conditions
- Acute Renal Failure, Chronic Kidney Failure, Endothelial Dysfunction, Hemolytic-uremic Syndrome (HUS)
- Trial name
- NCT00358306
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Polycystic Kidney, Autosomal Dominant
The Role of Endothelial Dysfunction in Adult Polycystic Kidney Disease
This pilot study will compare endothelial function in patients with ADPKD with matched healthy volunteers and normotensive chronic kidney disease stage 1 \& 2 patients.
- Trial name
- NCT04023214
- Testing
- Peripheral (digital) arterial tonometry
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Autonomic Dysfunction, Chronic Renal Failure
Autonomic Dysfunction and Inflammation in Chronic Hemodialysis Patients
This study investigates the relationship between autonomic dysfunction and chronic inflammation in hemodialysis patients.
- Trial name
- NCT00878033
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
CKD
Thyroid Dysfunction and Dyslipidemia in Patients With Chronic Kidney Diseases
Early diagnosis of thyroid and lipid disorders by regular screening, and treatment of such disorders in CKD patients may be highly beneficial to slow progression of CKD.
- Trial name
- NCT03277911
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Androgen Deprivation Therapy, Prostate Cancer
Autonomic and Renal Contributions to Hypertension With ADT
This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer.
- Conditions
- Androgen Deprivation Therapy, Prostate Cancer, Hypertension, Autonomic Dysfunction
- Trial name
- ARCH (NCT07848828)
- Testing
- Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Chronic Kidney Disease, Heart Failure With Preserved Ejection Fraction (HFPEF)
The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases.
- Conditions
- Chronic Kidney Disease, Heart Failure With Preserved Ejection Fraction (HFPEF), Obesity (Disorder)
- Trial name
- NCT07052539
- Testing
- High protein and sodium meal
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH)
A Single-Dose Pharmacokinetic Study of HRS-4729 Injection in Healthy Participants and Patients With Renal Impairment
This study aims to evaluate the pharmacokinetic effects of a single dose of HRS-4729 injection in participants with mild, moderate, and severe renal impairment, with 8 participants enrolled in each renal impairment group and 8…
- Conditions
- Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH), Type 2 Diabetes Mellitus
- Trial name
- NCT07807059
- Testing
- HRS-4729
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Chronic Kidney Disease, Acute Kidney Injuries
Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain.
- Conditions
- Chronic Kidney Disease, Acute Kidney Injuries, Real World Study, Dementia
- Trial name
- NCT07093684
- Testing
- Kidney disease
- Where
- Sweden
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet