Clinical trials: Kidney Functional
Chronic Kidney Diseases, Metabolic Syndrome
Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease
The pilot study will adopt a 2-arm, pretest-posttest, and assessor-blind randomized controlled trial design to examine the feasibility and acceptability of a theory-based health behaviour change intervention and examine its…
- Trial name
- NCT06527768
- Testing
- Theory-based health behaviour change interventio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Renal Insufficiency, Chronic
A Study to Evaluate the Blood Levels, Safety, and Tolerability of PF-00734200 in Subjects With Impaired Kidney Function and Normal Kidney Function
The purpose of this study is to compare how PF-00734200 is adsorbed, distributed, broken down and eliminated by subjects with mild, moderate and severe kidney impairment, by subjects receiving chronic hemodialysis, and by…
- Trial name
- NCT00596518
- Testing
- PF-00734200
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pfizer
Kidney Stone
Dietary Oxalate and Immune Cell Function
The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.
- Trial name
- NCT03877276
- Testing
- Breakfast, Spinach smoothie, Kale smoothie
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Prematurity of Fetus
Effect of Prematurity on Renal Function in 5 Years Old Children
Purpose of the study: 1. To evaluate the effect of prematurity on renal function in 5 years old children 2. To compare former premature children treated by ibuprofen in the neonatal period to controls
- Trial name
- SUIVIREIN (NCT00817921)
- Where
- 3 sites in France
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Jean Michel Hascoet
Acute Kidney Injury
External Validation of IRRIV Test Relationship With Renal Functional Reserve
The assessment of renal functional reserve (RFR) has been proposed for the risk stratification of patients undergoing potentially nephrotoxic procedures.
- Trial name
- IRRIV-RFR (NCT03756402)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ospedale San Bortolo di Vicenza
Healthy
Effect of Metamizole (Dipyrone) on Renal Function in Salt-depleted Healthy Subjects
The planned study is a single-center, randomized, open-label parallel group study in 16 healthy male subjects. Study subjects will be randomly allocated either to the metamizole group (1) or to the naproxen group (2).
- Trial name
- NCT01995006
- Testing
- metamizole, Naproxen
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Kidney Disease, Chronic
Diuretic Testing in Chronic Kidney Disease
The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease.
- Trial name
- U-TUBE 2 (NCT06841692)
- Testing
- Diuretic Testing
- Where
- Netherlands
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
HIV
Pharmacokinetics of Bictegravir in Adults With Normal and Impaired Renal Function
The primary objective of this study is to evaluate the pharmacokinetic (PK) profile of oral bictegravir (formerly GS-9883) in adults with impaired renal function relative to matched, healthy controls with normal renal function.
- Trial name
- NCT02400307
- Testing
- Bictegravir
- Where
- 7 sites in United States, New Zealand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Work Related Stress
Potential Benefits of the Somatic Psychoeducational Intervention
The goal of this clinical trial is to explore possible benefits and mechanisms through which the Somatic Psychoeducational Intervention can improve health and wellness in health care providers (HCP).
- Trial name
- NCT05766852
- Testing
- Somatic Psychoeducational Intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Kidney Disease
Study of Pharmacokinetics and Safety of Apraglutide in Participants With Normal and Impaired Kidney Function.
Study of pharmacokinetics and safety of apraglutide in participants with normal and impaired kidney function.
- Trial name
- NCT04699032
- Testing
- Apraglutide
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- VectivBio AG
Renal Impairment
Pharmacokinetics of Yimitasvir Phosphate Capsule in Subjects With Normal Renal Function and ESRD
This study is to evaluate the single-dose pharmacokinetics (PK) and safety of Yimitasvir phosphate capsule in participants with End-stage renal disease without hemodialysis using matched healthy participants as a control group.
- Trial name
- NCT04565171
- Testing
- Yimitasvir Phosphate Capsule
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Healthy, Renovascular Hypertension
Magnetic Resonance Imaging for Evaluating Kidney Function
Renovascular hypertension (RVH) is a potentially curable disease affecting 0.5-5 percent of patients with hypertension. The current diagnostic work-up of RVH involves a complex algorithm which includes doppler ultrasound…
- Trial name
- NCT00006173
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Subjects
Randomized, Placebo-controlled Study to Evaluate Effects of E5555 on Renal Function Parameters and OCT2 Activity
This is a drug-drug interaction study to evaluate the effects of steady-state exposure of E5555 and its main metabolites on the pharmacokinetics (PK) of metformin, an organic cation transporter-2 (OCT2) substrate.
- Trial name
- NCT01241669
- Testing
- E5555
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Hepatitis C Virus
Study to Evaluate the Pharmacokinetics of Velpatasvir in Participants With Normal Renal Function and Severe Renal Impairment
The primary objective of the study is to evaluate the single-dose pharmacokinetics (PK) of velpatasvir (formerly GS-5816) in participants with severe renal impairment using matched healthy participants as a control group.
- Trial name
- NCT02002767
- Testing
- Velpatasvir
- Where
- 5 sites in United States, New Zealand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Renal Failure
A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function
A study to evaluate the drug effect, safety, and tolerability of BMS-986259 in participants with different levels of kidney function
- Trial name
- NCT04237831
- Testing
- BMS-986259
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
End-stage Renal Disease
Functional Reserve Estimation of Donor Kidney
The purpose of the study: To estimate the role of morphological, clinical, biochemical and imaging studies at stages of kidney transplantation (medical therapy, explantation, preservation, transplantation).
- Trial name
- NCT01689272
- Testing
- Kidney Transplantation from alive relative donor
- Where
- Kazakhstan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nazarbayev University
Healthy
Short Term Effects of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects
We wanted to test the shortterm effects of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.
- Trial name
- NCT00345202
- Testing
- HMG-CoA reductase inhibition (atorvastatin)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Breast Carcinoma, Kidney Carcinoma
Functional Near-Infrared Spectroscopy and Virtual Reality Relaxation Programs for Pain Management in Patients With Cancer
This study aims to develop objective tools for assessing perceived pain severity in cancer patients and survivors, evaluate the sustained effectiveness of non-pharmacological interventions such as virtual reality in reducing pain…
- Conditions
- Breast Carcinoma, Kidney Carcinoma, Carcinoma
- Trial name
- NCT06456411
- Testing
- Functional Near-Infrared Spectroscopy, Questionnaire Administration, Virtual Technology Intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Renal Impairment, Healthy Volunteer
A Study to Assess the Safety of Experimental Medication BMS986165 in Participants With Normal Kidney Function and Participants With Mild to End-Stage Kidney Disease.
The purpose of this study is to investigate BMS-986165 in participants with different levels of kidney function.
- Trial name
- NCT03890770
- Testing
- BMS-986165
- Where
- 6 sites in United States, Czechia and 2 more
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb