Clinical trials: Kidney Functional
Gram-negative Bacterial Infections
Pharmacokinetics and Safety of HRS-8427 in Healthy Volunteers and in Patients With Impaired Renal Function
This study evaluated the pharmacokinetic profile, safety, and tolerability of HRS-8427 injection in subjects with mild, moderate, severe, or end-stage renal disease (ESRD) requiring dialysis, using subjects with normal renal…
- Trial name
- NCT07070375
- Testing
- HRS-8427
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy
Effect of Metamizole (Dipyrone) on Renal Function in Salt-depleted Healthy Subjects
The planned study is a single-center, randomized, open-label parallel group study in 16 healthy male subjects. Study subjects will be randomly allocated either to the metamizole group (1) or to the naproxen group (2).
- Trial name
- NCT01995006
- Testing
- metamizole, Naproxen
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Renal Impairment
A Study to Evaluate the Pharmacokinetics of HSK7653 in Subjects With Renal Impairment
This is an open-label, single-dose study to evaluate the pharmacokinetics, pharmacodynamics and safety of HSK7653 in subjects with mild, moderate, severe renal impairment and subjects with kidney failure compared to the matched…
- Trial name
- NCT05497297
- Testing
- HSK7653 tablets
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Kidney Stone
Dietary Oxalate and Immune Cell Function
The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.
- Trial name
- NCT03877276
- Testing
- Breakfast, Spinach smoothie, Kale smoothie
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Kidney Injury
Lithium Clearance in Patients With High Risk of Acute Kidney Injury
Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function. In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.
- Trial name
- NCT05648435
- Testing
- Lithium measures
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Renal Impairment, Tuberculosis
Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function
This is a Phase 1, open-label, single-dose, sequential group study to compare the safety and pharmacokinetics (PK) of pretomanid in the following groups of participants: 1) participants with severe renal impairment including…
- Trial name
- NCT03896750
- Testing
- PA-824
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Glomerulonephritis
Study of HRS-5965 in Healthy Subjects and Subjects With Renal Insufficiency
The trial is the first human trial. The safety, tolerability, PK and PD of HRS-5965 tablets will be evaluated in healthy subjects and subjects with impaired renal function.
- Trial name
- NCT05505955
- Testing
- HRS-5965
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Renal Insufficiency
Study to Evaluate Safety and Tolerability of Iberdomide (CC-220) in Participants With Kidney Impairment Compared to Participants With Normal Kidney Function
This is an open-label study of iberdomide in participants with severe renal impairment or participants receiving dialysis compared to participants with normal renal function.
- Trial name
- NCT04933747
- Testing
- Iberdomide
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Celgene
Impaired Renal Function
Study of Aldafermin (NGM282) in Participants With Impaired Renal Function
This is a single-center evaluation of Aldafermin (NGM282) in an open-label, single-dose and parallel group study in participants with Impaired Renal Function.
- Trial name
- NCT04179630
- Testing
- Aldafermin (NGM282)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NGM Biopharmaceuticals, Inc
Autism Spectrum Disorders
Brain Imaging Study of Adults With Autism Spectrum Disorders
This research study investigates the effects of oxytocin and vasopressin on brain activity in adults with Autism Spectrum Disorders using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT01093768
- Testing
- Oxytocin, Vasopressin
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Renal Impairment
A Pharmacokinetic Study of YM178 in Normal Subjects and Those With Mild, Moderate, and Severe Renal Impairment
The objective of this study is to assess and compare the pharmacokinetic properties of YM178 in normal subjects and those with mild, moderate and severe renal impairment.
- Trial name
- NCT00750620
- Testing
- YM178
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Pulmonary Hypertension, Chronic Kidney Disease
Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
- Trial name
- NCT06409624
- Testing
- No intervention is planned as part of the study
- Where
- 2 sites in Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Renal Insufficiency
Afatinib in Subjects With Kidney Dysfunction
The primary objective of the current study is to investigate the influence of moderate to severe renal impairment on the pharmacokinetics and safety of a single dose afatinib in comparison to a control group with normal renal…
- Trial name
- NCT02096718
- Testing
- Afatinib healthy, Afatinib severe renally impaired, Afatinib moderate renally impaired
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Congestive Heart Failure, Renal Impairment
A Study to Learn How the Study Treatment BAY1753011 Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body When Given Once as Tablet in Male and Female Participants With Reduced Kidney Function Compared to Matched Participants With Normal Kidney Function
Researchers are looking for a better way to treat people with heart failure. Heart failure is a condition which occurs when the heart does not pump blood as well as it should leading to shortness of breath, tiredness, and ankle…
- Trial name
- NCT05599997
- Testing
- Pecavaptan (BAY1753011)
- Where
- 2 sites in Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
The Impact of Extreme Physical Exertion on Health, The Impact of Extreme Physical Exertion on Glucose
A Comprehensive Interdisciplinary Assessment of the Impact of Ultramarathons on the Health of Middle-aged and Older Amateur Runners - SUPERMARATON 2025 Project
The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years.
- Conditions
- The Impact of Extreme Physical Exertion on Health, The Impact of Extreme Physical Exertion on Glucose, The Impact of Extreme Physical Exertion on Respiratory System, The Impact of Extreme Physical Exertion on Joints and Muscles
- Trial name
- NCT07451717
- Testing
- Blood and urine analysis
- Where
- Poland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Diabetic Nephropathies
Nitric Oxide (NO) Activity and Diabetic Nephropathy
Experimental data suggest that oxidative stress and endothelial dysfunction are key players in the pathogenesis of diabetic nephropathy.
- Trial name
- NCT00136188
- Testing
- Folic Acid
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Renal Insufficiency
Phase 1 Renal Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
Twenty-four subjects were divided into three groups: subjects with mild renal insufficiency, subjects with moderate renal insufficiency and subjects with normal renal function, with 8 subjects in each group.Subjects with mild…
- Trial name
- NCT06747520
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Healthy, Renal Impairment
A Study to Test How BI 456906 is Taken up in the Blood of People With and Without Kidney Problems
This study is open to adults aged between 18 and 80 years of age with a body mass index (BMI) of 20 to 40 kg/m2. People with or without kidney problems can take part in the study.
- Trial name
- NCT06352411
- Testing
- BI 456906
- Where
- 2 sites in Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hepatitis C Virus
Study to Evaluate the Pharmacokinetics of Velpatasvir in Participants With Normal Renal Function and Severe Renal Impairment
The primary objective of the study is to evaluate the single-dose pharmacokinetics (PK) of velpatasvir (formerly GS-5816) in participants with severe renal impairment using matched healthy participants as a control group.
- Trial name
- NCT02002767
- Testing
- Velpatasvir
- Where
- 5 sites in United States, New Zealand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Renal Function
Study of Ulipristal Acetate in Female Patients With Moderately or Severely Impaired Renal Function, Compared With Matched Healthy Female Subjects
This study is designed to observe the effect of renal function on the pharmacokinetic, safety, and tolerability profiles of Ulipristal acetate following administration of a single oral dose of a 10 mg Ulipristal acetate tablet.
- Trial name
- NCT02634437
- Testing
- Ulipristal acetate
- Where
- 5 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Allergan