Clinical trials: Kidney Functional
Chronic Kidney Diseases, Chronic Heart Failure
The Impact of CRT on Renal Function
The study is observational, prospective, including patients undergoing CRT-D / CRT-P implantation in the department of cardiology.
- Trial name
- NCT04516525
- Testing
- cardiac resynchronisation therapy (CRT) implantation
- Volunteers
- 74 people
- Sponsor
- University of Rzeszow
Chronic Kidney Disease, Congestive Heart Failure
Peritoneal Ultrafiltration to Treat Congestive Heart Failure
The purpose of this study is to determine whether the treatment of peritoneal ultrafiltration can improve survival and quality of life of refractory congestive heart failure with special accent on preserving residual renal…
- Trial name
- NCT02829450
- Testing
- peritoneal ultrafiltration
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
Renal Venous Return
Relationship Between Renal Venous Return and Prognosis of Renal Function in Patients With AKI in ICU
A single-center prospective longitudinal observational study was carried out. Assessments were made on Days 1, 3, 5, and 7 after ICU admission in 90 patients with sepsis AKI, and 19 patients with septic without AKI only made…
- Trial name
- NCT06159010
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking Union Medical College Hospital
Renal Impairment
Pharmacokinetic and Tolerability Study of 14 mg Single Dose of Teriflunomide in Subjects With Severe Renal Impairment
Primary Objective: To determine the effect of severe renal impairment on the pharmacokinetic profile of teriflunomide administered as a single 14 mg dose as compared to healthy subjects Secondary Objective: To assess the…
- Trial name
- NCT01239459
- Testing
- Teriflunomide HMR1726, Cholestyramine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Sanofi
Renal Impairment, Healthy
Pharmacokinetics Study of MCI-186 in Subjects With Mild or Moderate Renal Impairment
To assess the pharmacokinetics of MCI-186 after a single intravenous infusion of 30mg/hour in subjects with mild or moderate renal impairment compared to subjects with normal renal function.
- Trial name
- NCT03289208
- Testing
- MCI-186
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shionogi
Diabetic Nephropathy Type 2
Observational Study to Evaluate the Relationship Between Ketonemia and Renal Function in the Diabetic Patient
A multicentre real life study is proposed. The study has as its goal primary to compare the levels of ketonemia measured in patients with albuminuria and patients normo albuminurici to evaluate a possible correlation between…
- Trial name
- TAKEN-DKD (NCT03859817)
- Testing
- Comparison of eGFR values and ketonemia in diabetic patients
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Milan
Healthy Volunteer
A Study of Aleglitazar in Combination With Ibuprofen in Healthy Volunteers
This randomized, double-blind, placebo-controlled, parallel group study will investigate the safety and tolerability, and the effect of aleglitazar in combination with ibuprofen on renal function, renin-angiotensin system and…
- Trial name
- NCT01188317
- Testing
- aleglitazar, ibuprofen
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Renal Impairment
Pharmacokinetics of 10 mg Teduglutide in Subjects With Renal Impairment Compared to Healthy Subjects With Normal Renal Function
To evaluate the effect of renal impairment on the pharmacokinetics (PK) of teduglutide following subcutaneous (SC) administration of 10 mg teduglutide.
- Trial name
- NCT01028768
- Testing
- Teduglutide
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Nycomed
Cirrhosis, Liver, Splenectomy; Status
Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome).
- Conditions
- Cirrhosis, Liver, Splenectomy; Status, Renal Function Abnormal, Portal Hypertension
- Trial name
- LSD-RFPH (NCT07585786)
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Hypertension
The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Hypertensive Versus Healthy Subjects
The purpose of this study is to investigate how the effect of infused sodium nitrite differs in hypertensives compared to healthy age and sex matched controls.
- Trial name
- HYCA (NCT02527837)
- Testing
- Sodium nitrite, Sodium chloride
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
End Stage Renal Disease, Chronic Kidney Disease
Comparison of Dialysis Therapies on Cognitive Function
This study will evaluate the effects of more frequent dialysis on cognitive function including the assessment of sleep apnea and restless legs.
- Trial name
- NCT00597103
- Testing
- Cognitive Function Testing-10 Tests, Sleep Assessment Testing, Periodic Leg Movement Syndrome Assessment
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Satellite Healthcare
Cirrhosis, Splenectomy; Status
Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome).
- Conditions
- Cirrhosis, Splenectomy; Status, Hypersplenism, Kidney Function Issue
- Trial name
- LS-RF (NCT07585773)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Kidney Transplantation, Acute Kidney Tubular Necrosis
Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant.
This study is designed to investigate whether allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) can promote function recovery in patients with poor early graft function after kidney transplantation from Chinese…
- Trial name
- NCT02563366
- Testing
- BM-MSCs, Saline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
End Stage Renal Disease
Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients
Vascular access complications are the leading cause of morbidity in hemodialysis (HD) patients, and are responsible for a significant percentage of hospitalization, with annual costs approaching one billion dollars in the United…
- Trial name
- NCT01138254
- Testing
- WSTM TY101 FIR emitter (Far infrared therapy), no intervention
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy Subjects
Randomized, Placebo-controlled Study to Evaluate Effects of E5555 on Renal Function Parameters and OCT2 Activity
This is a drug-drug interaction study to evaluate the effects of steady-state exposure of E5555 and its main metabolites on the pharmacokinetics (PK) of metformin, an organic cation transporter-2 (OCT2) substrate.
- Trial name
- NCT01241669
- Testing
- E5555
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Cardiorenal Syndrome
Levosimendan Versus Dobutamine for Renal Function in Heart Failure
Although inotropes have a favorable effect on central hemodynamics in patients with heart failure, their effect on renal hemodynamics is incompletely defined.
- Trial name
- ELDOR (NCT02133105)
- Testing
- Levosimendan, Dobutamine
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Göteborg University
Renal Disease
Investigation of the Effect of Intradialytic Exercise on Functional Capacity,Quality of Life in Hemodialysis Patients
Chronic renal failure (CKD) is defined as a chronic, progressive degeneration in the kidney's fluid-electrolyte balance and metabolic-endocrine functions as a result of the glomerular filtration rate (GFR) falling below 60…
- Trial name
- NCT05246956
- Testing
- Intradialytic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul Medipol University Hospital
Congestive Heart Failure, Renal Insufficiency
Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure
The purpose of this study is to compare high dose furosemide in combination with low volume hypertonic saline solution (2.4%) with intermittent pulse dose furosemide in patients with pre treatment kidney function impairment.
- Trial name
- REaCH (NCT01028170)
- Testing
- furosemide and hypertonic saline solution, furosemide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aspirus Heart and Vascular Institute-Research and Education
Acute Decompensated Heart Failure
Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure
Heart failure is the most common hospital admission diagnosis and shows increasing incidence and prevalence in Germany, the United States and worldwide. Improvements in the primary treatment conditions for e.g.
- Trial name
- EMPAG-HF (NCT04049045)
- Testing
- Empagliflozin 25 mg
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Christian Schulze
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
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